Pancreatic cancer near the splenic hilum has a higher likelihood of splenic vessel invasion and unfavorable survival
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
PURPOSE: This study aimed to investigate whether clinical outcomes varied based on the tumor location within the pancreatic body and tail in patients with pancreatic cancer (PC).
METHODS: Ninety-five patients who had undergone a distal pancreatectomy for resectable (R) or borderline resectable (BR) PC within the pancreatic body or tail region were retrospectively investigated and divided into four groups (three subgroups of R-PC according to tumor location, and BR-PC): R-PC in the pancreatic body region (group A, n = 24), R-PC on the right side of the pancreatic tail region (group B, n = 17), R-PC on the left side of the pancreatic tail region (group C, n = 29), and BR-PC located in any region within the pancreatic body and tail (group BR, n = 25).
RESULTS: Group C patients showed a higher incidence of pretreatment splenic artery and vein involvement than group A and B patients (splenic artery: 8.3/11.8/41.4%, p < 0.010; splenic vein: 25.0/23.5/79.3%, p < 0.010, in groups A/B/C, respectively). The overall survival of group C patients was significantly unfavorable compared to that of group A and B patients (median: 3.9/4.2/2.3 years in groups A/B/C, p = 0.029, respectively). Pretreatment clinical factors were comparable between group C and group BR. Median survival rates were comparable between group C and BR patients (2.3 and 2.0 years, respectively) (p = 0.93).
CONCLUSIONS: Differences in anatomical location within the pancreatic body and tail characterize the unfavorable outcomes of PC near the splenic hilum.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:408 |
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| Enthalten in: |
Langenbeck's archives of surgery - 408(2023), 1 vom: 11. Sept., Seite 353 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ueda, Hiroki [VerfasserIn] |
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| Links: |
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| Themen: |
Anatomic location |
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| Anmerkungen: |
Date Completed 12.09.2023 Date Revised 18.01.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00423-023-03089-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361928491 |
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| 100 | 1 | |a Ueda, Hiroki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Pancreatic cancer near the splenic hilum has a higher likelihood of splenic vessel invasion and unfavorable survival |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 18.01.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a PURPOSE: This study aimed to investigate whether clinical outcomes varied based on the tumor location within the pancreatic body and tail in patients with pancreatic cancer (PC) | ||
| 520 | |a METHODS: Ninety-five patients who had undergone a distal pancreatectomy for resectable (R) or borderline resectable (BR) PC within the pancreatic body or tail region were retrospectively investigated and divided into four groups (three subgroups of R-PC according to tumor location, and BR-PC): R-PC in the pancreatic body region (group A, n = 24), R-PC on the right side of the pancreatic tail region (group B, n = 17), R-PC on the left side of the pancreatic tail region (group C, n = 29), and BR-PC located in any region within the pancreatic body and tail (group BR, n = 25) | ||
| 520 | |a RESULTS: Group C patients showed a higher incidence of pretreatment splenic artery and vein involvement than group A and B patients (splenic artery: 8.3/11.8/41.4%, p < 0.010; splenic vein: 25.0/23.5/79.3%, p < 0.010, in groups A/B/C, respectively). The overall survival of group C patients was significantly unfavorable compared to that of group A and B patients (median: 3.9/4.2/2.3 years in groups A/B/C, p = 0.029, respectively). Pretreatment clinical factors were comparable between group C and group BR. Median survival rates were comparable between group C and BR patients (2.3 and 2.0 years, respectively) (p = 0.93) | ||
| 520 | |a CONCLUSIONS: Differences in anatomical location within the pancreatic body and tail characterize the unfavorable outcomes of PC near the splenic hilum | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anatomic location | |
| 650 | 4 | |a Clinical outcomes | |
| 650 | 4 | |a Pancreatic cancer | |
| 650 | 4 | |a Splenic hilum | |
| 650 | 4 | |a Splenic vessel invasion | |
| 650 | 4 | |a Survival | |
| 700 | 1 | |a Takahashi, Hidenori |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, Shogo |e verfasserin |4 aut | |
| 700 | 1 | |a Sasaki, Kazuki |e verfasserin |4 aut | |
| 700 | 1 | |a Iwagami, Yoshihumi |e verfasserin |4 aut | |
| 700 | 1 | |a Yamada, Daisaku |e verfasserin |4 aut | |
| 700 | 1 | |a Tomimaru, Yoshito |e verfasserin |4 aut | |
| 700 | 1 | |a Asaoka, Tadafumi |e verfasserin |4 aut | |
| 700 | 1 | |a Noda, Takehiro |e verfasserin |4 aut | |
| 700 | 1 | |a Tanemura, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Doki, Yuichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Eguchi, Hidetoshi |e verfasserin |4 aut | |
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