Association between PD-L1 and Ki-67 expression and clinicopathologic features in NSCLC patients
AJTR Copyright © 2023..
OBJECTIVE: To investigate the relationship between PD-L1, Ki-67 and the association between PD-L1, Ki-67, and clinicopathologic features and laboratory parameters in the peripheral blood of non-small cell lung cancer (NSCLC) patients.
METHODS: The clinical records of 213 NSCLC patients were retrospectively reviewed. The patients were divided into high or low expression groups by cut-off values of Ki-67 and PD-L1. Correlation of PD-L1 and Ki-67 expression were analyzed by linear regression analysis. The data were tested by Mann-Whitney test. Relationship of PD-L1 and Ki-67 was tested by chi-square test.
RESULTS: Linear regression analysis revealed a positive association between the expression of PD-L1 and Ki-67 (R2=0.26, P<0.001). The clinicopathologic features and laboratory parameters such as gender, smoking history, histological types, TNM stage, tumor size, ALB, and FIB were all significantly associated with PD-L1 and Ki-67 expression (all P<0.05).
CONCLUSIONS: The expression of PD-L1 and Ki-67 is related to some clinicopathologic features and inflammatory factors, which brings new sight for exploiting combination biomarkers and therapeutic strategies.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
American journal of translational research - 15(2023), 8 vom: 24., Seite 5339-5346 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhu, Qing [VerfasserIn] |
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| Themen: |
Inflammation |
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| Anmerkungen: |
Date Revised 13.09.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM36190438X |
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| 100 | 1 | |a Zhu, Qing |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association between PD-L1 and Ki-67 expression and clinicopathologic features in NSCLC patients |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
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| 500 | |a Date Revised 13.09.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a AJTR Copyright © 2023. | ||
| 520 | |a OBJECTIVE: To investigate the relationship between PD-L1, Ki-67 and the association between PD-L1, Ki-67, and clinicopathologic features and laboratory parameters in the peripheral blood of non-small cell lung cancer (NSCLC) patients | ||
| 520 | |a METHODS: The clinical records of 213 NSCLC patients were retrospectively reviewed. The patients were divided into high or low expression groups by cut-off values of Ki-67 and PD-L1. Correlation of PD-L1 and Ki-67 expression were analyzed by linear regression analysis. The data were tested by Mann-Whitney test. Relationship of PD-L1 and Ki-67 was tested by chi-square test | ||
| 520 | |a RESULTS: Linear regression analysis revealed a positive association between the expression of PD-L1 and Ki-67 (R2=0.26, P<0.001). The clinicopathologic features and laboratory parameters such as gender, smoking history, histological types, TNM stage, tumor size, ALB, and FIB were all significantly associated with PD-L1 and Ki-67 expression (all P<0.05) | ||
| 520 | |a CONCLUSIONS: The expression of PD-L1 and Ki-67 is related to some clinicopathologic features and inflammatory factors, which brings new sight for exploiting combination biomarkers and therapeutic strategies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Ki-67 | |
| 650 | 4 | |a Non-small cell lung cancer | |
| 650 | 4 | |a PD-L1 | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a proliferation | |
| 700 | 1 | |a Zhang, Jingwen |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Derong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Rui |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t American journal of translational research |d 2009 |g 15(2023), 8 vom: 24., Seite 5339-5346 |w (DE-627)NLM193229463 |x 1943-8141 |7 nnns |
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