Radiomics Analysis of Diffusion Kurtosis Imaging : Distinguishing Between Glioblastoma and Single Brain Metastasis
Copyright © 2024 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved..
RATIONALE AND OBJECTIVES: This study aimed to assess the value of diffusion kurtosis imaging (DKI)-based radiomics models in differentiating glioblastoma (GB) from single brain metastasis (SBM) and compare their diagnostic performance with that of routine magnetic resonance imaging (MRI) models.
MATERIALS AND METHODS: A total of 110 patients who underwent DKI and were pathologically diagnosed with GB (n = 58) or SBM (n = 52) were enrolled in this study. Radiomics features were extracted from the manually delineated region of interest of the lesion. A training set for model development was constructed from the images of 88 random patients, and 22 patients were reserved for independent validation. Seven single-DKI-parametric models and a multi-DKI-parametric model were constructed using six classifiers, whereas four single-routine-sequence models (based on T2 weighted imaging, apparent diffusion coefficient, T2-dark-fluid, and contrast-enhanced T1 magnetization prepared rapid gradient echo) and a multisequence routine MRI model were constructed for comparison. Receiver operating characteristic curve analysis was conducted to assess the diagnostic performance. The areas under the curve (AUCs) of different models were compared using the DeLong test.
RESULTS: The AUCs of the single-DKI-parametric models ranged from 0.800 to 0.933 (mean kurtosis [MK] model). The multi-DKI-parametric model had a slightly higher AUC (0.958) than the MK model; however, the difference was not statistically significant (P = 0.688). In comparison, the AUCs of the routine MRI models ranged from 0.633 to 0.733 (multisequence routine MRI model). The AUC of the multi-DKI-parametric model was significantly higher than that of the multisequence routine MRI model (P = 0.042).
CONCLUSION: The multi-DKI-parametric radiomics model exhibited better performance than that of the single-DKI-parametric models and routine MRI models in distinguishing GB from SBM.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
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| Enthalten in: |
Academic radiology - 31(2024), 3 vom: 31. März, Seite 1036-1043 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gao, Eryuan [VerfasserIn] |
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| Links: |
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| Themen: |
Diffusion kurtosis imaging |
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| Anmerkungen: |
Date Completed 25.03.2024 Date Revised 25.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.acra.2023.07.023 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361883676 |
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| 100 | 1 | |a Gao, Eryuan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Radiomics Analysis of Diffusion Kurtosis Imaging |b Distinguishing Between Glioblastoma and Single Brain Metastasis |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a RATIONALE AND OBJECTIVES: This study aimed to assess the value of diffusion kurtosis imaging (DKI)-based radiomics models in differentiating glioblastoma (GB) from single brain metastasis (SBM) and compare their diagnostic performance with that of routine magnetic resonance imaging (MRI) models | ||
| 520 | |a MATERIALS AND METHODS: A total of 110 patients who underwent DKI and were pathologically diagnosed with GB (n = 58) or SBM (n = 52) were enrolled in this study. Radiomics features were extracted from the manually delineated region of interest of the lesion. A training set for model development was constructed from the images of 88 random patients, and 22 patients were reserved for independent validation. Seven single-DKI-parametric models and a multi-DKI-parametric model were constructed using six classifiers, whereas four single-routine-sequence models (based on T2 weighted imaging, apparent diffusion coefficient, T2-dark-fluid, and contrast-enhanced T1 magnetization prepared rapid gradient echo) and a multisequence routine MRI model were constructed for comparison. Receiver operating characteristic curve analysis was conducted to assess the diagnostic performance. The areas under the curve (AUCs) of different models were compared using the DeLong test | ||
| 520 | |a RESULTS: The AUCs of the single-DKI-parametric models ranged from 0.800 to 0.933 (mean kurtosis [MK] model). The multi-DKI-parametric model had a slightly higher AUC (0.958) than the MK model; however, the difference was not statistically significant (P = 0.688). In comparison, the AUCs of the routine MRI models ranged from 0.633 to 0.733 (multisequence routine MRI model). The AUC of the multi-DKI-parametric model was significantly higher than that of the multisequence routine MRI model (P = 0.042) | ||
| 520 | |a CONCLUSION: The multi-DKI-parametric radiomics model exhibited better performance than that of the single-DKI-parametric models and routine MRI models in distinguishing GB from SBM | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Radiomics | |
| 650 | 4 | |a diffusion kurtosis imaging | |
| 650 | 4 | |a glioblastoma | |
| 650 | 4 | |a single brain metastasis | |
| 700 | 1 | |a Wang, Peipei |e verfasserin |4 aut | |
| 700 | 1 | |a Bai, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Xiaoyue |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Yufei |e verfasserin |4 aut | |
| 700 | 1 | |a Qi, Jinbo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Huiting |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Xu |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Guang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Guohua |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Jingliang |e verfasserin |4 aut | |
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