Exploring the relationship between urinary phthalate metabolites and Crohn's disease via oxidative stress, and the potential moderating role of gut microbiota : A conditional mediation model
Copyright © 2023 Elsevier Inc. All rights reserved..
OBJECTIVE: Interactions between phthalic acid esters (PAEs) exposure and Crohn's disease (CD) were unknown. This study aims to examine the association between exposure to PAEs and CD activity and to explore the roles of oxidative stress and microbiota.
METHODS: A cross-sectional study with 127 CD patients was conducted. The disease activity was evaluated based on symptoms (Harvey-Bradshaw index, HBI), endoscopy findings (Simple Endoscopic Score for CD, SES-CD), and computed tomography enterography (CTE-scores). Ten urinary PAEs metabolites (mPAEs), two urinary oxidative stress biomarkers, including 8-hydroxydeoxyguanosine (8-OHdG) and 8-iso-prostaglandin-F2α (8-iso-PGF2α), as well as 16S rRNA sequencing of stool samples were determined. Multiple linear regression models and Hayes's PROCESS macro for SPSS were used to evaluate the interplays between urinary PAEs metabolites, CD activities, oxidative stress, and microbiota diversity.
RESULTS: There were positive associations between most mPAEs and HBI. Oxidative stress mediated 20.69-89.29% of the indirect associations between low molecular weight (LMW) mPAEs and HBI, while the majority of the high molecular weight (HMW) mPAEs were directly associated with HBI. In addition, microbiota diversity moderated the indirect associations of LMW mPAEs on HBI.
CONCLUSIONS: PAEs exposure was related to CD activity, and the association could be mediated by oxidative stress and reversed or alleviated by rich gut microbiota.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:208 |
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Enthalten in: |
Free radical biology & medicine - 208(2023) vom: 01. Nov., Seite 468-477 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Xiong, Danping [VerfasserIn] |
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Links: |
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Themen: |
6O7F7IX66E |
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Anmerkungen: |
Date Completed 23.10.2023 Date Revised 23.10.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.freeradbiomed.2023.09.005 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM361881568 |
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100 | 1 | |a Xiong, Danping |e verfasserin |4 aut | |
245 | 1 | 0 | |a Exploring the relationship between urinary phthalate metabolites and Crohn's disease via oxidative stress, and the potential moderating role of gut microbiota |b A conditional mediation model |
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500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
520 | |a OBJECTIVE: Interactions between phthalic acid esters (PAEs) exposure and Crohn's disease (CD) were unknown. This study aims to examine the association between exposure to PAEs and CD activity and to explore the roles of oxidative stress and microbiota | ||
520 | |a METHODS: A cross-sectional study with 127 CD patients was conducted. The disease activity was evaluated based on symptoms (Harvey-Bradshaw index, HBI), endoscopy findings (Simple Endoscopic Score for CD, SES-CD), and computed tomography enterography (CTE-scores). Ten urinary PAEs metabolites (mPAEs), two urinary oxidative stress biomarkers, including 8-hydroxydeoxyguanosine (8-OHdG) and 8-iso-prostaglandin-F2α (8-iso-PGF2α), as well as 16S rRNA sequencing of stool samples were determined. Multiple linear regression models and Hayes's PROCESS macro for SPSS were used to evaluate the interplays between urinary PAEs metabolites, CD activities, oxidative stress, and microbiota diversity | ||
520 | |a RESULTS: There were positive associations between most mPAEs and HBI. Oxidative stress mediated 20.69-89.29% of the indirect associations between low molecular weight (LMW) mPAEs and HBI, while the majority of the high molecular weight (HMW) mPAEs were directly associated with HBI. In addition, microbiota diversity moderated the indirect associations of LMW mPAEs on HBI | ||
520 | |a CONCLUSIONS: PAEs exposure was related to CD activity, and the association could be mediated by oxidative stress and reversed or alleviated by rich gut microbiota | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Crohn's disease (CD) | |
650 | 4 | |a Gut microbiota | |
650 | 4 | |a Oxidative stress | |
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700 | 1 | |a Zhu, Siran |e verfasserin |4 aut | |
700 | 1 | |a Liu, Linlin |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Lei |e verfasserin |4 aut | |
700 | 1 | |a Zeng, Cui |e verfasserin |4 aut | |
700 | 1 | |a Li, Yanling |e verfasserin |4 aut | |
700 | 1 | |a Wang, Huan |e verfasserin |4 aut | |
700 | 1 | |a Tu, Lei |e verfasserin |4 aut | |
700 | 1 | |a Zou, Kaifang |e verfasserin |4 aut | |
700 | 1 | |a Hou, Xiaohua |e verfasserin |4 aut | |
700 | 1 | |a Yang, Liangle |e verfasserin |4 aut | |
700 | 1 | |a Zhu, Liangru |e verfasserin |4 aut | |
700 | 1 | |a Bai, Tao |e verfasserin |4 aut | |
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