Multispectral and molecular dynamics study on the impact of trans, trans-2,4-decadienal and 4-hydroxy-2-nonenal on myoglobin redox stability
Copyright © 2023 Elsevier Ltd. All rights reserved..
This study investigated the interaction between myoglobin (Mb) and two lipid oxidation products, 4-hydroxy-2-nonenal (HNE) and trans, trans-2,4-decadienal (tt-DDE), at pH 5.6 and 7.4 through the combination of multispectral and molecular dynamics simulations. In this study, tt-DDE was more prone to promote Mb oxidation than HNE by loosening the Mb structure, which is associated with more destroyed secondary and tertiary structures. Furthermore, the pro-oxidation of both lipid products was stronger at pH 5.6 than at pH 7.4. The molecular docking revealed that both tt-DDE and HNE were combined closely with the heme group of Mb. And tt-DDE had hydrogen bonds, hydrophobic interactions, and van der Waals forces with Mb, but HNE only had hydrophobic interactions. In conclusion, it was firstly found that tt-DDE was also shown to have high activity in promoting Mb oxidation as another important aldehyde from lipid oxidation products.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 2023 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:433 |
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| Enthalten in: |
Food chemistry - 433(2023) vom: 01. Feb., Seite 137366 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Qi, Jiajing [VerfasserIn] |
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| Links: |
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| Themen: |
Fluorescence quenching |
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| Anmerkungen: |
Date Revised 11.10.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.foodchem.2023.137366 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361863179 |
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| 500 | |a Date Revised 11.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2023 Elsevier Ltd. All rights reserved. | ||
| 520 | |a This study investigated the interaction between myoglobin (Mb) and two lipid oxidation products, 4-hydroxy-2-nonenal (HNE) and trans, trans-2,4-decadienal (tt-DDE), at pH 5.6 and 7.4 through the combination of multispectral and molecular dynamics simulations. In this study, tt-DDE was more prone to promote Mb oxidation than HNE by loosening the Mb structure, which is associated with more destroyed secondary and tertiary structures. Furthermore, the pro-oxidation of both lipid products was stronger at pH 5.6 than at pH 7.4. The molecular docking revealed that both tt-DDE and HNE were combined closely with the heme group of Mb. And tt-DDE had hydrogen bonds, hydrophobic interactions, and van der Waals forces with Mb, but HNE only had hydrophobic interactions. In conclusion, it was firstly found that tt-DDE was also shown to have high activity in promoting Mb oxidation as another important aldehyde from lipid oxidation products | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Fluorescence quenching | |
| 650 | 4 | |a Lipid oxidation products | |
| 650 | 4 | |a Molecular dynamics simulation | |
| 650 | 4 | |a Myoglobin | |
| 650 | 4 | |a Trans, trans - 2, 4 - decadienal | |
| 700 | 1 | |a Yang, Xiaoyin |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yimin |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Yanwei |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Baochen |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Lixian |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Rongrong |e verfasserin |4 aut | |
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