Serum brain damage biomarkers as a diagnostic and prognostic tool in ischemic stroke
OBJECTIVE: To study serum quantities of neuron specific enolase (NSE), glial fibrillary acidic protein (GFAP) and NR2-antibodies (NR2-ab) in various cerebrovascular pathology and assess their value as a panel used as a diagnostic and predictive tool for stroke.
MATERIAL AND METHODS: NSE, GFAP and NR2-ab serum levels were measured twice for 84 patients with ischemic stroke (IS) and 8 patients with hemorrhagic stroke (HI), once for 8 patients with transient ischemic attack (TIA), 26 patients with chronic brain ischemia (CBI), 27 healthy volunteers (HV).
RESULTS: NSE and GFAP levels were significantly higher in IS than in CBI and HV patients, and NR2-ab levels in IS were higher than in TIA and lower than in HV. In patients with more pronounced neurological deficiency and less favorable functional outcome by day 10-14 of IS, the levels of NSE, GFAP and NR2-ab were higher. Sensitivity and specificity of biomarker panel was higher than with their separate application.
CONCLUSION: The NSE, GFAP and NR2-ab biomarkers have a diagnostic and predictive value for IS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:123 |
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| Enthalten in: |
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 123(2023), 8. Vyp. 2 vom: 23., Seite 37-46 |
| Sprache: |
Russisch |
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| Weiterer Titel: |
Syvorotochnye biomarkery porazheniya mozga kak diagnosticheskii i prognosticheskii instrument pri ishemicheskom insul'te |
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| Beteiligte Personen: |
Chaykovskaya, A D [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies |
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| Anmerkungen: |
Date Completed 11.09.2023 Date Revised 11.09.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.17116/jnevro202312308237 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361796293 |
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| 100 | 1 | |a Chaykovskaya, A D |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Serum brain damage biomarkers as a diagnostic and prognostic tool in ischemic stroke |
| 246 | 3 | 3 | |a Syvorotochnye biomarkery porazheniya mozga kak diagnosticheskii i prognosticheskii instrument pri ishemicheskom insul'te |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 11.09.2023 | ||
| 500 | |a Date Revised 11.09.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To study serum quantities of neuron specific enolase (NSE), glial fibrillary acidic protein (GFAP) and NR2-antibodies (NR2-ab) in various cerebrovascular pathology and assess their value as a panel used as a diagnostic and predictive tool for stroke | ||
| 520 | |a MATERIAL AND METHODS: NSE, GFAP and NR2-ab serum levels were measured twice for 84 patients with ischemic stroke (IS) and 8 patients with hemorrhagic stroke (HI), once for 8 patients with transient ischemic attack (TIA), 26 patients with chronic brain ischemia (CBI), 27 healthy volunteers (HV) | ||
| 520 | |a RESULTS: NSE and GFAP levels were significantly higher in IS than in CBI and HV patients, and NR2-ab levels in IS were higher than in TIA and lower than in HV. In patients with more pronounced neurological deficiency and less favorable functional outcome by day 10-14 of IS, the levels of NSE, GFAP and NR2-ab were higher. Sensitivity and specificity of biomarker panel was higher than with their separate application | ||
| 520 | |a CONCLUSION: The NSE, GFAP and NR2-ab biomarkers have a diagnostic and predictive value for IS | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a NR2-antibodies | |
| 650 | 4 | |a biomarker panel | |
| 650 | 4 | |a diagnostics | |
| 650 | 4 | |a glial fibrillary acidic protein | |
| 650 | 4 | |a ischemic stroke | |
| 650 | 4 | |a neuron-specific enolase | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a stroke | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Antibodies |2 NLM | |
| 700 | 1 | |a Topuzova, M P |e verfasserin |4 aut | |
| 700 | 1 | |a Ternovykh, I K |e verfasserin |4 aut | |
| 700 | 1 | |a Makhanova, A M |e verfasserin |4 aut | |
| 700 | 1 | |a Mikheeva, A G |e verfasserin |4 aut | |
| 700 | 1 | |a Pospelova, M L |e verfasserin |4 aut | |
| 700 | 1 | |a Panina, E B |e verfasserin |4 aut | |
| 700 | 1 | |a Vavilova, T V |e verfasserin |4 aut | |
| 700 | 1 | |a Vasilieva, E Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Shustova, T A |e verfasserin |4 aut | |
| 700 | 1 | |a Alekseeva, T M |e verfasserin |4 aut | |
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