Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease : A Large European Prospective Cohort
© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society..
BACKGROUND: Metals have been postulated as environmental concerns in the etiology of Parkinson's disease (PD), but metal levels are typically measured after diagnosis, which might be subject to reverse causality.
OBJECTIVE: The aim of this study was to investigate the association between prediagnostic blood metal levels and PD risk.
METHODS: A case-control study was nested in a prospective European cohort, using erythrocyte samples collected before PD diagnosis.
RESULTS: Most assessed metals were not associated with PD risk. Cadmium has a suggestive negative association with PD (odds ratio [95% confidence interval] for the highest quartile, 0.70 [0.42-1.17]), which diminished among never smokers. Among current smokers only, lead was associated with decreased PD risk (0.06 [0.01-0.35]), whereas arsenic showed associations toward an increased PD risk (1.85 [0.45-7.93]).
CONCLUSIONS: We observe no strong evidence to support a role of metals in the development of PD. In particular, smoking may confound the association with tobacco-derived metals. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
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| Enthalten in: |
Movement disorders : official journal of the Movement Disorder Society - 38(2023), 12 vom: 06. Dez., Seite 2302-2307 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhao, Yujia [VerfasserIn] |
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| Links: |
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| Themen: |
Cohort study |
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| Anmerkungen: |
Date Completed 21.12.2023 Date Revised 20.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/mds.29602 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361732929 |
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| 100 | 1 | |a Zhao, Yujia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease |b A Large European Prospective Cohort |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. | ||
| 520 | |a BACKGROUND: Metals have been postulated as environmental concerns in the etiology of Parkinson's disease (PD), but metal levels are typically measured after diagnosis, which might be subject to reverse causality | ||
| 520 | |a OBJECTIVE: The aim of this study was to investigate the association between prediagnostic blood metal levels and PD risk | ||
| 520 | |a METHODS: A case-control study was nested in a prospective European cohort, using erythrocyte samples collected before PD diagnosis | ||
| 520 | |a RESULTS: Most assessed metals were not associated with PD risk. Cadmium has a suggestive negative association with PD (odds ratio [95% confidence interval] for the highest quartile, 0.70 [0.42-1.17]), which diminished among never smokers. Among current smokers only, lead was associated with decreased PD risk (0.06 [0.01-0.35]), whereas arsenic showed associations toward an increased PD risk (1.85 [0.45-7.93]) | ||
| 520 | |a CONCLUSIONS: We observe no strong evidence to support a role of metals in the development of PD. In particular, smoking may confound the association with tobacco-derived metals. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a cohort study | |
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| 650 | 4 | |a prospective exposure assessment | |
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| 700 | 1 | |a Lill, Christina M |e verfasserin |4 aut | |
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| 700 | 1 | |a Katzke, Verena A |e verfasserin |4 aut | |
| 700 | 1 | |a Rodriguez-Barranco, Miguel |e verfasserin |4 aut | |
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