Discovery of phytochelatins in human urine : Evidence for function in selenium disposition and protection against cadmium
© 2023 The Authors. FASEB BioAdvances published by Wiley Periodicals LLC on behalf of The Federation of American Societies for Experimental Biology..
This report identifies, for the first time, a phytochelatin compound, phytochelatin 2 [γ-E-C-γ-E-C-G], and related metabolites in human urine. Phytochelatins are metal-binding peptides produced by plants. They are present in nearly all human diets, due to their ubiquity in plants. The urinary concentration of phytochelatin 2 among 143 adults was in the low micromolar range, and phytochelatin 2 and its metabolites had differential correlations with urinary selenium and toxic metals. Activities of ingested phytochelatins are largely undescribed. Observed urinary metal interactions were investigated further in cell and animal models. Selenite reacted with phytochelatin to form a phytochelatin selenotrisulfide, and the preformed selenotrisulfide showed increased selenium uptake by renal proximal tubule cells. In vivo studies further showed that oral phytochelatin increased renal selenium content and decreased lung cadmium in mice. Presence of phytochelatin in human urine combined with its function in selenium and heavy metal distribution present a new route by which diet may influence metal disposition and bioavailability.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
|---|---|
| Enthalten in: |
FASEB bioAdvances - 5(2023), 9 vom: 11. Sept., Seite 367-375 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Jarrell, Zachery R [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cadmium |
|---|
| Anmerkungen: |
Date Revised 08.09.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1096/fba.2023-00050 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM361721811 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM361721811 | ||
| 003 | DE-627 | ||
| 005 | 20231226085736.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1096/fba.2023-00050 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1205.xml |
| 035 | |a (DE-627)NLM361721811 | ||
| 035 | |a (NLM)37674541 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Jarrell, Zachery R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Discovery of phytochelatins in human urine |b Evidence for function in selenium disposition and protection against cadmium |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 08.09.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 The Authors. FASEB BioAdvances published by Wiley Periodicals LLC on behalf of The Federation of American Societies for Experimental Biology. | ||
| 520 | |a This report identifies, for the first time, a phytochelatin compound, phytochelatin 2 [γ-E-C-γ-E-C-G], and related metabolites in human urine. Phytochelatins are metal-binding peptides produced by plants. They are present in nearly all human diets, due to their ubiquity in plants. The urinary concentration of phytochelatin 2 among 143 adults was in the low micromolar range, and phytochelatin 2 and its metabolites had differential correlations with urinary selenium and toxic metals. Activities of ingested phytochelatins are largely undescribed. Observed urinary metal interactions were investigated further in cell and animal models. Selenite reacted with phytochelatin to form a phytochelatin selenotrisulfide, and the preformed selenotrisulfide showed increased selenium uptake by renal proximal tubule cells. In vivo studies further showed that oral phytochelatin increased renal selenium content and decreased lung cadmium in mice. Presence of phytochelatin in human urine combined with its function in selenium and heavy metal distribution present a new route by which diet may influence metal disposition and bioavailability | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a cadmium | |
| 650 | 4 | |a chelating agents | |
| 650 | 4 | |a diet | |
| 650 | 4 | |a metabolism | |
| 650 | 4 | |a phytochelatins | |
| 650 | 4 | |a selenium | |
| 700 | 1 | |a Liu, Ken H |e verfasserin |4 aut | |
| 700 | 1 | |a Dennis, Kristine K |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Martin, Greg S |e verfasserin |4 aut | |
| 700 | 1 | |a Jones, Dean P |e verfasserin |4 aut | |
| 700 | 1 | |a Go, Young-Mi |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t FASEB bioAdvances |d 2019 |g 5(2023), 9 vom: 11. Sept., Seite 367-375 |w (DE-627)NLM293664617 |x 2573-9832 |7 nnns |
| 773 | 1 | 8 | |g volume:5 |g year:2023 |g number:9 |g day:11 |g month:09 |g pages:367-375 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1096/fba.2023-00050 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 5 |j 2023 |e 9 |b 11 |c 09 |h 367-375 | ||