Granulocyte-colony stimulating factor-producing multiple myeloma presenting with neutrophilia
A 71-year-old woman complained of nausea and anorexia. Laboratory tests revealed significant neutrophilia and immunoglobulin A-kappa type M proteinemia, as well as increased plasma cells on bone marrow examination. Furthermore, the serum granulocyte-colony stimulating factor (G-CSF) concentration was high at 160 pg/ml, and the colony stimulating factor 3 receptor (CSF3R)-T618I mutation was negative. Immunohistochemical (IHC) analysis of bone marrow specimens using the anti-G-CSF antibody revealed immunopositivity of some myeloma cells. The patient was diagnosed using G-CSF-producing myeloma and was treated with daratumumab, lenalidomide, and dexamethasone. Her treatment resulted in a very good partial response, with normalization of both serum G-CSF levels and neutrophil count. There have been a few cases of G-CSF -producing myeloma reported, and it has previously been reported as chronic neutrophilic leukemia with M proteinemia. According to previous reports, techniques such as serum G-CSF measurements, IHC with an anti-G-CSF antibody, and CSF3R gene mutation analysis are useful for differentiating G-CSF-producing myeloma. However, the clinical characteristics and long-term prognosis of G-CSF-producing myeloma remain unknown. Additional case gathering and investigations are required.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
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| Enthalten in: |
Rinsho ketsueki] The Japanese journal of clinical hematology - 64(2023), 8 vom: 05., Seite 735-740 |
| Sprache: |
Japanisch |
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| Beteiligte Personen: |
Yokoi, Momoko [VerfasserIn] |
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| Links: |
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| Themen: |
143011-72-7 |
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| Anmerkungen: |
Date Completed 08.09.2023 Date Revised 08.09.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.11406/rinketsu.64.735 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361712707 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A 71-year-old woman complained of nausea and anorexia. Laboratory tests revealed significant neutrophilia and immunoglobulin A-kappa type M proteinemia, as well as increased plasma cells on bone marrow examination. Furthermore, the serum granulocyte-colony stimulating factor (G-CSF) concentration was high at 160 pg/ml, and the colony stimulating factor 3 receptor (CSF3R)-T618I mutation was negative. Immunohistochemical (IHC) analysis of bone marrow specimens using the anti-G-CSF antibody revealed immunopositivity of some myeloma cells. The patient was diagnosed using G-CSF-producing myeloma and was treated with daratumumab, lenalidomide, and dexamethasone. Her treatment resulted in a very good partial response, with normalization of both serum G-CSF levels and neutrophil count. There have been a few cases of G-CSF -producing myeloma reported, and it has previously been reported as chronic neutrophilic leukemia with M proteinemia. According to previous reports, techniques such as serum G-CSF measurements, IHC with an anti-G-CSF antibody, and CSF3R gene mutation analysis are useful for differentiating G-CSF-producing myeloma. However, the clinical characteristics and long-term prognosis of G-CSF-producing myeloma remain unknown. Additional case gathering and investigations are required | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Granulocyte-colony stimulating factor | |
| 650 | 4 | |a Myeloma | |
| 650 | 4 | |a Neutrophilia | |
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| 700 | 1 | |a Shimizu, Risa |e verfasserin |4 aut | |
| 700 | 1 | |a Uchida, Keiichi |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashi, Shigeki |e verfasserin |4 aut | |
| 700 | 1 | |a Nishimura, Hirotake |e verfasserin |4 aut | |
| 700 | 1 | |a Kondo, Eisei |e verfasserin |4 aut | |
| 700 | 1 | |a Wada, Hideho |e verfasserin |4 aut | |
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