An exploration of biomarkers for noise exposure : mitochondrial DNA copy number and micronucleus frequencies in Chinese workers
Few studies have been conducted that use biomarkers as early warning signals for noise-associated health hazards. To explore potentially effective biomarkers for noise-exposed populations, we recruited 218 noise-exposed male workers in China. We calculated cumulative noise exposure (CNE) through noise intensity and noise-exposed duration. When the model was fully adjusted, ln-transformed relative mitochondrial DNA copy number (mtDNAcn) decreased by 0.014 (95% confidence interval (CI): -0.026, -0.003) units with each 1 dB(A)∙year increase in CNE levels. CNE was further included in the model as a grouping variable, and the results showed a negative dose-effect relationship between relative mtDNAcn and CNE (P-trend = 0.045). However, we did not find a correlation between CNE and micronucleus (MN) frequencies. Our findings suggest that CNE in workers was associated with a decrease in relative mtDNAcn which may provide a potential biomarker for noise and for certain health risk but not with MN frequencies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
International journal of environmental health research - (2023) vom: 05. Sept., Seite 1-11 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yang, Jia-Hao [VerfasserIn] |
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| Links: |
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| Themen: |
Cumulative noise exposure |
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| Anmerkungen: |
Date Revised 28.11.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1080/09603123.2023.2253739 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM36167421X |
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| 100 | 1 | |a Yang, Jia-Hao |e verfasserin |4 aut | |
| 245 | 1 | 3 | |a An exploration of biomarkers for noise exposure |b mitochondrial DNA copy number and micronucleus frequencies in Chinese workers |
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| 520 | |a Few studies have been conducted that use biomarkers as early warning signals for noise-associated health hazards. To explore potentially effective biomarkers for noise-exposed populations, we recruited 218 noise-exposed male workers in China. We calculated cumulative noise exposure (CNE) through noise intensity and noise-exposed duration. When the model was fully adjusted, ln-transformed relative mitochondrial DNA copy number (mtDNAcn) decreased by 0.014 (95% confidence interval (CI): -0.026, -0.003) units with each 1 dB(A)∙year increase in CNE levels. CNE was further included in the model as a grouping variable, and the results showed a negative dose-effect relationship between relative mtDNAcn and CNE (P-trend = 0.045). However, we did not find a correlation between CNE and micronucleus (MN) frequencies. Our findings suggest that CNE in workers was associated with a decrease in relative mtDNAcn which may provide a potential biomarker for noise and for certain health risk but not with MN frequencies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cumulative noise exposure | |
| 650 | 4 | |a DNA damage | |
| 650 | 4 | |a mitochondrial DNA copy number | |
| 700 | 1 | |a Liu, Wu-Zhong |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Qian-Kui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xue-Tao |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Zhao-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Au, William |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Pin |e verfasserin |4 aut | |
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