Cardiovascular human organ-on-a-chip platform for disease modeling, drug development, and personalized therapy
© 2023 Wiley Periodicals LLC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA..
Cardiovascular organ-on-a-chip (OoC) devices are composed of engineered or native functional tissues that are cultured under controlled microenvironments inside microchips. These systems employ microfabrication and tissue engineering techniques to recapitulate human physiology. This review focuses on human OoC systems to model cardiovascular diseases, to perform drug screening, and to advance personalized medicine. We also address the challenges in the generation of organ chips that can revolutionize the large-scale application of these systems for drug development and personalized therapy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:112 |
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| Enthalten in: |
Journal of biomedical materials research. Part A - 112(2024), 4 vom: 12. Apr., Seite 512-523 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Khanna, Astha [VerfasserIn] |
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| Links: |
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| Themen: |
Biomaterials |
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| Anmerkungen: |
Date Completed 16.02.2024 Date Revised 15.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jbm.a.37602 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM361658958 |
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| 520 | |a Cardiovascular organ-on-a-chip (OoC) devices are composed of engineered or native functional tissues that are cultured under controlled microenvironments inside microchips. These systems employ microfabrication and tissue engineering techniques to recapitulate human physiology. This review focuses on human OoC systems to model cardiovascular diseases, to perform drug screening, and to advance personalized medicine. We also address the challenges in the generation of organ chips that can revolutionize the large-scale application of these systems for drug development and personalized therapy | ||
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