Influence of poly-L-ornithine-bile acid nano hydrogels on cellular bioactivity and potential pharmacological applications
Aim: Cellular bioactivity and pathophysiological changes associated with chronic disorders are considered pivotal detrimental factors when developing novel formulations for biomedical applications. Methods: This paper investigates the use of bile acids and synthetic polypeptide poly-L-ornithine (PLO) in formulations and their impacts on a variety of cell lines, with a particular focus on their cellular bioactivity. Results: The hepatic cell line was the most negatively affected by the presence of PLO, while the muscle and beta-pancreatic cell lines did not show as profound of a negative impact of PLO on cellular viability. PLO was the least disruptive regarding mitochondrial function for muscle and beta cells. Conclusion: The addition of bile acids generally decreased mitochondrial respiration and altered bioenergetic parameters in all cell lines.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Therapeutic delivery - (2023) vom: 05. Sept. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kovacevic, Bozica [VerfasserIn] |
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| Links: |
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| Themen: |
Bile acid |
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| Anmerkungen: |
Date Revised 05.09.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.4155/tde-2023-0034 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361656122 |
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| 100 | 1 | |a Kovacevic, Bozica |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Influence of poly-L-ornithine-bile acid nano hydrogels on cellular bioactivity and potential pharmacological applications |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 05.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Aim: Cellular bioactivity and pathophysiological changes associated with chronic disorders are considered pivotal detrimental factors when developing novel formulations for biomedical applications. Methods: This paper investigates the use of bile acids and synthetic polypeptide poly-L-ornithine (PLO) in formulations and their impacts on a variety of cell lines, with a particular focus on their cellular bioactivity. Results: The hepatic cell line was the most negatively affected by the presence of PLO, while the muscle and beta-pancreatic cell lines did not show as profound of a negative impact of PLO on cellular viability. PLO was the least disruptive regarding mitochondrial function for muscle and beta cells. Conclusion: The addition of bile acids generally decreased mitochondrial respiration and altered bioenergetic parameters in all cell lines | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a bile acid | |
| 650 | 4 | |a biocompatibility | |
| 650 | 4 | |a bioenergetics | |
| 650 | 4 | |a hepatic cells | |
| 650 | 4 | |a muscle cells | |
| 650 | 4 | |a pancreatic beta cells | |
| 650 | 4 | |a poloxamer 407 | |
| 650 | 4 | |a poly-L-ornithine | |
| 700 | 1 | |a Jones, Melissa |e verfasserin |4 aut | |
| 700 | 1 | |a Wagle, Susbin Raj |e verfasserin |4 aut | |
| 700 | 1 | |a Ionescu, Corina Mihaela |e verfasserin |4 aut | |
| 700 | 1 | |a Foster, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Đanić, Maja |e verfasserin |4 aut | |
| 700 | 1 | |a Mikov, Momir |e verfasserin |4 aut | |
| 700 | 1 | |a Mooranian, Armin |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Salami, Hani |e verfasserin |4 aut | |
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