Nomogram for the prediction of crescent formation in IgA nephropathy patients : a retrospective study
© 2023. BioMed Central Ltd., part of Springer Nature..
BACKGROUND: The 2017 Oxford classification of immunoglobulin A nephropathy (IgAN) recently reported that crescents could predict a worse renal outcome. Early prediction of crescent formation can help physicians determine the appropriate intervention, and thus, improve the outcomes. Therefore, we aimed to establish a nomogram model for the prediction of crescent formation in IgA nephropathy patients.
METHODS: We retrospectively analyzed 200 cases of biopsy-proven IgAN patients. Least absolute shrinkage and selection operator(LASSO) regression and multivariate logistic regression was applied to screen for influencing factors of crescent formation in IgAN patients. The performance of the proposed nomogram was evaluated based on Harrell's concordance index (C-index), calibration plot, and decision curve analysis.
RESULTS: Multivariate logistic analysis showed that urinary protein ≥ 1 g (OR = 3.129, 95%CI = 1.454-6.732), urinary red blood cell (URBC) counts ≥ 30/ul (OR = 3.190, 95%CI = 1.590-6.402), mALBU ≥ 1500 mg/L(OR = 2.330, 95%CI = 1.008-5.386), eGFR < 60ml/min/1.73m2(OR = 2.295, 95%CI = 1.016-5.187), Serum IgA/C3 ratio ≥ 2.59 (OR = 2.505, 95%CI = 1.241-5.057), were independent risk factors for crescent formation. Incorporating these factors, our model achieved well-fitted calibration curves and a good C-index of 0.776 (95%CI [0.711-0.840]) in predicting crescent formation.
CONCLUSIONS: Our nomogram showed good calibration and was effective in predicting crescent formation risk in IgAN patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
BMC nephrology - 24(2023), 1 vom: 04. Sept., Seite 262 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lin, Zaoqiang [VerfasserIn] |
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| Links: |
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| Themen: |
Crescent |
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| Anmerkungen: |
Date Completed 06.09.2023 Date Revised 22.11.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12882-023-03310-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a BACKGROUND: The 2017 Oxford classification of immunoglobulin A nephropathy (IgAN) recently reported that crescents could predict a worse renal outcome. Early prediction of crescent formation can help physicians determine the appropriate intervention, and thus, improve the outcomes. Therefore, we aimed to establish a nomogram model for the prediction of crescent formation in IgA nephropathy patients | ||
| 520 | |a METHODS: We retrospectively analyzed 200 cases of biopsy-proven IgAN patients. Least absolute shrinkage and selection operator(LASSO) regression and multivariate logistic regression was applied to screen for influencing factors of crescent formation in IgAN patients. The performance of the proposed nomogram was evaluated based on Harrell's concordance index (C-index), calibration plot, and decision curve analysis | ||
| 520 | |a RESULTS: Multivariate logistic analysis showed that urinary protein ≥ 1 g (OR = 3.129, 95%CI = 1.454-6.732), urinary red blood cell (URBC) counts ≥ 30/ul (OR = 3.190, 95%CI = 1.590-6.402), mALBU ≥ 1500 mg/L(OR = 2.330, 95%CI = 1.008-5.386), eGFR < 60ml/min/1.73m2(OR = 2.295, 95%CI = 1.016-5.187), Serum IgA/C3 ratio ≥ 2.59 (OR = 2.505, 95%CI = 1.241-5.057), were independent risk factors for crescent formation. Incorporating these factors, our model achieved well-fitted calibration curves and a good C-index of 0.776 (95%CI [0.711-0.840]) in predicting crescent formation | ||
| 520 | |a CONCLUSIONS: Our nomogram showed good calibration and was effective in predicting crescent formation risk in IgAN patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Crescent | |
| 650 | 4 | |a IgA nephropathy | |
| 650 | 4 | |a Nomogram | |
| 650 | 4 | |a Prediction | |
| 700 | 1 | |a Feng, Liuchang |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Huan |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Xuefei |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Qizhan |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Fuhua |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Lixin |e verfasserin |4 aut | |
| 700 | 1 | |a Mai, Jianling |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Pingjun |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xusheng |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Qinxiang |e verfasserin |4 aut | |
| 700 | 1 | |a Zou, Chuan |e verfasserin |4 aut | |
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