Emerging structural and pathological analyses on the erectile organ, corpus cavernous containing sinusoids
© 2023 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine..
Background: The corpus cavernosum (CC) containing sinusoids plays fundamental roles for erection. Analysis of pathological changes in the erectile system is studied by recent experimental systems. Various in vitro models utilizing genital mesenchymal-derived cells and explant culture systems are summarized.
Methods: 3D reconstruction of section images of murine CC was created. Ectopic chondrogenesis in aged mouse CC was shown by a gene expression study revealing the prominent expression of Sox9. Various experimental strategies utilizing mesenchyme-derived primary cells and tissue explants are introduced.
Main Findings: Possible roles of Sox9 in chondrogenesis and its regulation by several signals are suggested. The unique character of genital mesenchyme is shown by various analyses of external genitalia (ExG) derived cells and explant cultures. Such strategies are also applied to the analysis of erectile contraction/relaxation responses to many signals and aging process.
Conclusion: Erectile dysfunction (ED) is one of the essential topics for the modern aged society. More comprehensive studies are necessary to reveal the nature of the erectile system by combining multiple cell culture strategies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Reproductive medicine and biology - 22(2023), 1 vom: 28. Jan., Seite e12539 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hashimoto, Daiki [VerfasserIn] |
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| Links: |
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| Themen: |
Corpus cavernosum |
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| Anmerkungen: |
Date Revised 05.09.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1002/rmb2.12539 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361616740 |
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| 245 | 1 | 0 | |a Emerging structural and pathological analyses on the erectile organ, corpus cavernous containing sinusoids |
| 264 | 1 | |c 2023 | |
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| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Revised 05.09.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. | ||
| 520 | |a Background: The corpus cavernosum (CC) containing sinusoids plays fundamental roles for erection. Analysis of pathological changes in the erectile system is studied by recent experimental systems. Various in vitro models utilizing genital mesenchymal-derived cells and explant culture systems are summarized | ||
| 520 | |a Methods: 3D reconstruction of section images of murine CC was created. Ectopic chondrogenesis in aged mouse CC was shown by a gene expression study revealing the prominent expression of Sox9. Various experimental strategies utilizing mesenchyme-derived primary cells and tissue explants are introduced | ||
| 520 | |a Main Findings: Possible roles of Sox9 in chondrogenesis and its regulation by several signals are suggested. The unique character of genital mesenchyme is shown by various analyses of external genitalia (ExG) derived cells and explant cultures. Such strategies are also applied to the analysis of erectile contraction/relaxation responses to many signals and aging process | ||
| 520 | |a Conclusion: Erectile dysfunction (ED) is one of the essential topics for the modern aged society. More comprehensive studies are necessary to reveal the nature of the erectile system by combining multiple cell culture strategies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a corpus cavernosum | |
| 650 | 4 | |a erectile dysfunction | |
| 650 | 4 | |a erection | |
| 650 | 4 | |a penis | |
| 650 | 4 | |a sinusoids | |
| 700 | 1 | |a Fujimoto, Kota |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Sang Woon |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Yong Seung |e verfasserin |4 aut | |
| 700 | 1 | |a Nakata, Masanori |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Kentaro |e verfasserin |4 aut | |
| 700 | 1 | |a Wada, Yoshitaka |e verfasserin |4 aut | |
| 700 | 1 | |a Asamura, Shinichi |e verfasserin |4 aut | |
| 700 | 1 | |a Yamada, Gen |e verfasserin |4 aut | |
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