Adult T-cell leukemia/lymphoma in HTLV-1 non-endemic regions
Copyright © 2023 Elsevier B.V. All rights reserved..
BACKGROUND: HTLV-1 infection is a neglected disease, despite producing neurological and lymphoproliferative severe illnesses and affect over 10 million people worldwide. Roughly 5% of HTLV-1 carriers develop Adult T-cell leukemia/lymphoma (ATLL), one of the most aggressive hematological malignancies.
METHODS: A national HTLV-1 register exists since 1989 in Spain, a non-endemic country with a large migrant flow from Latin America and Equatorial Africa, where HTLV-1 is endemic. The main features of all patients diagnosed with ATLL in Spain up to date are reported.
RESULTS: A total of 451 cases of HTLV-1 infection had been reported in Spain until the end of year 2022. ATLL had been diagnosed in 35 (7.8%). The current average incidence of ATLL in Spain is of two cases per year. Women represent 57% of ATLL patients. Mean age at diagnosis was 47 years-old. Roughly 57% were Latin Americans and 26% Africans. At diagnosis, the majority presented with acute or lymphoma clinical forms. Survival was shorter than one year in most of them. Mean HTLV-1 proviral load was significantly greater in ATLL patients than in asymptomatic HTLV-1 carriers (2,305 vs 104 copies/104 PBMC). HTLV-1 subtyping in 6 ATLL patients found the 1a transcontinental variant (n = 4) and the Japanese variant (n = 2). All ATLL patients were negative for HIV-1, did not develop HTLV-1-associated myelopathy and were not transplant recipients.
CONCLUSION: The rate of ATLL is very low in Spain and mostly associated to migrants from HTLV-1 endemic regions. Given the poor clinical outcome of ATLL, HTLV-1 testing should be performed at least once in all migrants coming from HTLV-1 endemic countries and in natives who have lived in or had sex partners from such regions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:167 |
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| Enthalten in: |
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 167(2023) vom: 01. Okt., Seite 105578 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Mendoza, Carmen [VerfasserIn] |
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| Links: |
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| Themen: |
Adult T-cell leukemia |
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| Anmerkungen: |
Date Completed 25.09.2023 Date Revised 26.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jcv.2023.105578 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361581572 |
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| 500 | |a Date Revised 26.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: HTLV-1 infection is a neglected disease, despite producing neurological and lymphoproliferative severe illnesses and affect over 10 million people worldwide. Roughly 5% of HTLV-1 carriers develop Adult T-cell leukemia/lymphoma (ATLL), one of the most aggressive hematological malignancies | ||
| 520 | |a METHODS: A national HTLV-1 register exists since 1989 in Spain, a non-endemic country with a large migrant flow from Latin America and Equatorial Africa, where HTLV-1 is endemic. The main features of all patients diagnosed with ATLL in Spain up to date are reported | ||
| 520 | |a RESULTS: A total of 451 cases of HTLV-1 infection had been reported in Spain until the end of year 2022. ATLL had been diagnosed in 35 (7.8%). The current average incidence of ATLL in Spain is of two cases per year. Women represent 57% of ATLL patients. Mean age at diagnosis was 47 years-old. Roughly 57% were Latin Americans and 26% Africans. At diagnosis, the majority presented with acute or lymphoma clinical forms. Survival was shorter than one year in most of them. Mean HTLV-1 proviral load was significantly greater in ATLL patients than in asymptomatic HTLV-1 carriers (2,305 vs 104 copies/104 PBMC). HTLV-1 subtyping in 6 ATLL patients found the 1a transcontinental variant (n = 4) and the Japanese variant (n = 2). All ATLL patients were negative for HIV-1, did not develop HTLV-1-associated myelopathy and were not transplant recipients | ||
| 520 | |a CONCLUSION: The rate of ATLL is very low in Spain and mostly associated to migrants from HTLV-1 endemic regions. Given the poor clinical outcome of ATLL, HTLV-1 testing should be performed at least once in all migrants coming from HTLV-1 endemic countries and in natives who have lived in or had sex partners from such regions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Adult T-cell leukemia | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a HTLV-1 | |
| 650 | 4 | |a Lymphoma | |
| 650 | 4 | |a Prenatal screening | |
| 650 | 4 | |a Testing | |
| 700 | 1 | |a Rando, Ariadna |e verfasserin |4 aut | |
| 700 | 1 | |a Miró, Elisenda |e verfasserin |4 aut | |
| 700 | 1 | |a Pena, María José |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Avial, Iciar |e verfasserin |4 aut | |
| 700 | 1 | |a Ortega, Diego |e verfasserin |4 aut | |
| 700 | 1 | |a González-Praetorius, Alejandro |e verfasserin |4 aut | |
| 700 | 1 | |a Reina, Gabriel |e verfasserin |4 aut | |
| 700 | 1 | |a Pintos, Ilduara |e verfasserin |4 aut | |
| 700 | 1 | |a Pozuelo, María José |e verfasserin |4 aut | |
| 700 | 1 | |a Soriano, Vicente |e verfasserin |4 aut | |
| 700 | 0 | |a Spanish HTLV Network |e verfasserin |4 aut | |
| 700 | 1 | |a Calderón, E |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez-Iglesias, M |e investigator |4 oth | |
| 700 | 1 | |a Montiel, N |e investigator |4 oth | |
| 700 | 1 | |a Trujillo, T |e investigator |4 oth | |
| 700 | 1 | |a Viciana, I |e investigator |4 oth | |
| 700 | 1 | |a Cabezas, T |e investigator |4 oth | |
| 700 | 1 | |a Lozano, A |e investigator |4 oth | |
| 700 | 1 | |a Fernández-Fuertes, E |e investigator |4 oth | |
| 700 | 1 | |a Fernández, J M |e investigator |4 oth | |
| 700 | 1 | |a García, F |e investigator |4 oth | |
| 700 | 1 | |a Benito, R |e investigator |4 oth | |
| 700 | 1 | |a Algarate, S |e investigator |4 oth | |
| 700 | 1 | |a Ducons, M |e investigator |4 oth | |
| 700 | 1 | |a Roc, L |e investigator |4 oth | |
| 700 | 1 | |a Cifuentes, C |e investigator |4 oth | |
| 700 | 1 | |a Fernández-Baca, V |e investigator |4 oth | |
| 700 | 1 | |a Fernández-Montero, J V |e investigator |4 oth | |
| 700 | 1 | |a Maciá, M D |e investigator |4 oth | |
| 700 | 1 | |a Hernández-Betancor, A |e investigator |4 oth | |
| 700 | 1 | |a Martín, A M |e investigator |4 oth | |
| 700 | 1 | |a Pena, M J |e investigator |4 oth | |
| 700 | 1 | |a Hernández, M |e investigator |4 oth | |
| 700 | 1 | |a López-Lirola, A M |e investigator |4 oth | |
| 700 | 1 | |a Gómez-Sirvent, J L |e investigator |4 oth | |
| 700 | 1 | |a Copado, R |e investigator |4 oth | |
| 700 | 1 | |a Cano, M E |e investigator |4 oth | |
| 700 | 1 | |a Rojo, S |e investigator |4 oth | |
| 700 | 1 | |a Eirós, J M |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez, M |e investigator |4 oth | |
| 700 | 1 | |a Gómez-Hernando, C |e investigator |4 oth | |
| 700 | 1 | |a González-Praetorius, A |e investigator |4 oth | |
| 700 | 1 | |a Rando, A |e investigator |4 oth | |
| 700 | 1 | |a Force, L |e investigator |4 oth | |
| 700 | 1 | |a Miró, E |e investigator |4 oth | |
| 700 | 1 | |a Cebollero, A |e investigator |4 oth | |
| 700 | 1 | |a Delgado, J F |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez, G |e investigator |4 oth | |
| 700 | 1 | |a Fernández-Pereira, L |e investigator |4 oth | |
| 700 | 1 | |a Aguilera, A |e investigator |4 oth | |
| 700 | 1 | |a Pereira, S |e investigator |4 oth | |
| 700 | 1 | |a García, J |e investigator |4 oth | |
| 700 | 1 | |a Trigo, M |e investigator |4 oth | |
| 700 | 1 | |a Diz, J |e investigator |4 oth | |
| 700 | 1 | |a García-Campello, M |e investigator |4 oth | |
| 700 | 1 | |a Cortizo, S |e investigator |4 oth | |
| 700 | 1 | |a Pérez, S |e investigator |4 oth | |
| 700 | 1 | |a Morano, L |e investigator |4 oth | |
| 700 | 1 | |a Reina, G |e investigator |4 oth | |
| 700 | 1 | |a Arazamendi, M |e investigator |4 oth | |
| 700 | 1 | |a Salicio, Y |e investigator |4 oth | |
| 700 | 1 | |a Ugalde, E |e investigator |4 oth | |
| 700 | 1 | |a Nieto, M C |e investigator |4 oth | |
| 700 | 1 | |a Liendo, P |e investigator |4 oth | |
| 700 | 1 | |a Goikoetxea, A J |e investigator |4 oth | |
| 700 | 1 | |a Ocete, M D |e investigator |4 oth | |
| 700 | 1 | |a Ramos, J M |e investigator |4 oth | |
| 700 | 1 | |a Escribano, I |e investigator |4 oth | |
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| 700 | 1 | |a Pirón, M |e investigator |4 oth | |
| 700 | 1 | |a González, R |e investigator |4 oth | |
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| 700 | 1 | |a Del Romero, J |e investigator |4 oth | |
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| 700 | 1 | |a Martín-Carbonero, L |e investigator |4 oth | |
| 700 | 1 | |a Fernández-Ruiz, M |e investigator |4 oth | |
| 700 | 1 | |a Parra, P |e investigator |4 oth | |
| 700 | 1 | |a Redondo, N |e investigator |4 oth | |
| 700 | 1 | |a Ruiz-Merlo, T |e investigator |4 oth | |
| 700 | 1 | |a Pozuelo, M J |e investigator |4 oth | |
| 700 | 1 | |a Barreiro, P |e investigator |4 oth | |
| 700 | 1 | |a Treviño, A |e investigator |4 oth | |
| 700 | 1 | |a Corral, O |e investigator |4 oth | |
| 700 | 1 | |a Soriano, V |e investigator |4 oth | |
| 700 | 1 | |a Pintos, I |e investigator |4 oth | |
| 700 | 1 | |a Moreno-Torres, V |e investigator |4 oth | |
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