Labor market affiliation of patients with myeloproliferative neoplasms : a population-based matched cohort study
BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) suffer from substantial symptoms and risk of debilitating complications, yet observational data on their labor market affiliation are scarce.
MATERIAL AND METHODS: We conducted a descriptive cohort study using data from Danish nationwide registries, including patients diagnosed with MPN in 2010-2016. Each patient was matched with up to ten comparators without MPN on age, sex, level of education, and region of residence. We assessed pre- and post-diagnosis labor market affiliation, defined as working, unemployed, or receiving sickness benefit, disability pension, retirement pension, or other health-related benefits. Labor market affiliation was assessed weekly from two years pre-diagnosis until death, emigration, or 31 December 2018. For patients and comparators, we reported percentage point (pp) changes in labor market affiliation cross-sectionally from week -104 pre-diagnosis to week 104 post-diagnosis.
RESULTS: The study included 3,342 patients with MPN and 32,737 comparators. From two years pre-diagnosis until two years post-diagnosis, a larger reduction in the proportion working was observed among patients than comparators (essential thrombocythemia: 10.2 [95% CI: 6.3-14.1] vs. 6.8 [95% CI: 5.5-8.0] pp; polycythemia vera: 9.6 [95% CI: 5.9-13.2] vs. 7.4 [95% CI: 6.2-8.7] pp; myelofibrosis: 8.1 [95% CI: 3.0-13.2] vs. 5.8 [95% CI: 4.2-7.5] pp; and unclassifiable MPN: 8.0 [95% CI: 3.0-13.0] vs. 7.4 [95% CI: 5.7-9.1] pp). Correspondingly, an increase in the proportion of patients receiving sickness benefits including other health-related benefits was evident around the time of diagnosis.
CONCLUSION: Overall, we found that Danish patients with essential thrombocythemia, polycythemia vera, myelofibrosis, and unclassifiable MPN had slightly impaired labor market affiliation compared with a population of the same age and sex. From two years pre-diagnosis to two years post-diagnosis, we observed a larger reduction in the proportion of patients with MPN working and a greater proportion receiving sickness benefits compared with matched individuals.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
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| Enthalten in: |
Acta oncologica (Stockholm, Sweden) - 62(2023), 10 vom: 01. Okt., Seite 1286-1294 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Svingel, Lise Skovgaard [VerfasserIn] |
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| Links: |
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| Themen: |
Cohort studies |
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| Anmerkungen: |
Date Completed 08.11.2023 Date Revised 08.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/0284186X.2023.2251670 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) suffer from substantial symptoms and risk of debilitating complications, yet observational data on their labor market affiliation are scarce | ||
| 520 | |a MATERIAL AND METHODS: We conducted a descriptive cohort study using data from Danish nationwide registries, including patients diagnosed with MPN in 2010-2016. Each patient was matched with up to ten comparators without MPN on age, sex, level of education, and region of residence. We assessed pre- and post-diagnosis labor market affiliation, defined as working, unemployed, or receiving sickness benefit, disability pension, retirement pension, or other health-related benefits. Labor market affiliation was assessed weekly from two years pre-diagnosis until death, emigration, or 31 December 2018. For patients and comparators, we reported percentage point (pp) changes in labor market affiliation cross-sectionally from week -104 pre-diagnosis to week 104 post-diagnosis | ||
| 520 | |a RESULTS: The study included 3,342 patients with MPN and 32,737 comparators. From two years pre-diagnosis until two years post-diagnosis, a larger reduction in the proportion working was observed among patients than comparators (essential thrombocythemia: 10.2 [95% CI: 6.3-14.1] vs. 6.8 [95% CI: 5.5-8.0] pp; polycythemia vera: 9.6 [95% CI: 5.9-13.2] vs. 7.4 [95% CI: 6.2-8.7] pp; myelofibrosis: 8.1 [95% CI: 3.0-13.2] vs. 5.8 [95% CI: 4.2-7.5] pp; and unclassifiable MPN: 8.0 [95% CI: 3.0-13.0] vs. 7.4 [95% CI: 5.7-9.1] pp). Correspondingly, an increase in the proportion of patients receiving sickness benefits including other health-related benefits was evident around the time of diagnosis | ||
| 520 | |a CONCLUSION: Overall, we found that Danish patients with essential thrombocythemia, polycythemia vera, myelofibrosis, and unclassifiable MPN had slightly impaired labor market affiliation compared with a population of the same age and sex. From two years pre-diagnosis to two years post-diagnosis, we observed a larger reduction in the proportion of patients with MPN working and a greater proportion receiving sickness benefits compared with matched individuals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Myeloproliferative disorder | |
| 650 | 4 | |a cohort studies | |
| 650 | 4 | |a employment | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a matched groups | |
| 650 | 4 | |a population characteristics | |
| 700 | 1 | |a Christensen, Sarah Friis |e verfasserin |4 aut | |
| 700 | 1 | |a Kjærsgaard, Anders |e verfasserin |4 aut | |
| 700 | 1 | |a Stenling, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Paulsson, Björn |e verfasserin |4 aut | |
| 700 | 1 | |a Andersen, Christen Lykkegaard |e verfasserin |4 aut | |
| 700 | 1 | |a Christiansen, Christian Fynbo |e verfasserin |4 aut | |
| 700 | 1 | |a Stentoft, Jesper |e verfasserin |4 aut | |
| 700 | 1 | |a Starklint, Jørn |e verfasserin |4 aut | |
| 700 | 1 | |a Severinsen, Marianne Tang |e verfasserin |4 aut | |
| 700 | 1 | |a Borg Clausen, Mette |e verfasserin |4 aut | |
| 700 | 1 | |a Hagemann Hilsøe, Morten |e verfasserin |4 aut | |
| 700 | 1 | |a Hasselbalch, Hans Carl |e verfasserin |4 aut | |
| 700 | 1 | |a Frederiksen, Henrik |e verfasserin |4 aut | |
| 700 | 1 | |a Bak, Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Mikkelsen, Ellen Margrethe |e verfasserin |4 aut | |
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