Genomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazil
Despite the considerable morbidity and mortality of yellow fever virus (YFV) infections in Brazil, our understanding of disease outbreaks is hampered by limited viral genomic data. Here, through a combination of phylogenetic and epidemiological models, we reconstructed the recent transmission history of YFV within different epidemic seasons in Brazil. A suitability index based on the highly domesticated Aedes aegypti was able to capture the seasonality of reported human infections. Spatial modeling revealed spatial hotspots with both past reporting and low vaccination coverage, which coincided with many of the largest urban centers in the Southeast. Phylodynamic analysis unraveled the circulation of three distinct lineages and provided proof of the directionality of a known spatial corridor that connects the endemic North with the extra-Amazonian basin. This study illustrates that genomics linked with eco-epidemiology can provide new insights into the landscape of YFV transmission, augmenting traditional approaches to infectious disease surveillance and control.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
|---|---|
| Enthalten in: |
Science advances - 9(2023), 35 vom: 01. Sept., Seite eadg9204 |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 11.02.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1126/sciadv.adg9204 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM361545568 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM361545568 | ||
| 003 | DE-627 | ||
| 005 | 20240211231917.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1126/sciadv.adg9204 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1288.xml |
| 035 | |a (DE-627)NLM361545568 | ||
| 035 | |a (NLM)37656782 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Giovanetti, Marta |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Genomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazil |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.12.2023 | ||
| 500 | |a Date Revised 11.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Despite the considerable morbidity and mortality of yellow fever virus (YFV) infections in Brazil, our understanding of disease outbreaks is hampered by limited viral genomic data. Here, through a combination of phylogenetic and epidemiological models, we reconstructed the recent transmission history of YFV within different epidemic seasons in Brazil. A suitability index based on the highly domesticated Aedes aegypti was able to capture the seasonality of reported human infections. Spatial modeling revealed spatial hotspots with both past reporting and low vaccination coverage, which coincided with many of the largest urban centers in the Southeast. Phylodynamic analysis unraveled the circulation of three distinct lineages and provided proof of the directionality of a known spatial corridor that connects the endemic North with the extra-Amazonian basin. This study illustrates that genomics linked with eco-epidemiology can provide new insights into the landscape of YFV transmission, augmenting traditional approaches to infectious disease surveillance and control | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Pinotti, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Zanluca, Camila |e verfasserin |4 aut | |
| 700 | 1 | |a Fonseca, Vagner |e verfasserin |4 aut | |
| 700 | 1 | |a Nakase, Taishi |e verfasserin |4 aut | |
| 700 | 1 | |a Koishi, Andrea C |e verfasserin |4 aut | |
| 700 | 1 | |a Tscha, Marcel |e verfasserin |4 aut | |
| 700 | 1 | |a Soares, Guilherme |e verfasserin |4 aut | |
| 700 | 1 | |a Dorl, Gisiane Gruber |e verfasserin |4 aut | |
| 700 | 1 | |a Marques, Antônio Ernesto M L |e verfasserin |4 aut | |
| 700 | 1 | |a Sousa, Renato |e verfasserin |4 aut | |
| 700 | 1 | |a Adelino, Talita Emile Ribeiro |e verfasserin |4 aut | |
| 700 | 1 | |a Xavier, Joilson |e verfasserin |4 aut | |
| 700 | 1 | |a de Oliveira, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Patroca, Sandro |e verfasserin |4 aut | |
| 700 | 1 | |a Guimaraes, Natalia Rocha |e verfasserin |4 aut | |
| 700 | 1 | |a Fritsch, Hegger |e verfasserin |4 aut | |
| 700 | 1 | |a Mares-Guia, Maria Angélica |e verfasserin |4 aut | |
| 700 | 1 | |a Levy, Flavia |e verfasserin |4 aut | |
| 700 | 1 | |a Passos, Pedro Henrique |e verfasserin |4 aut | |
| 700 | 1 | |a da Silva, Vinicius Leme |e verfasserin |4 aut | |
| 700 | 1 | |a Pereira, Luiz Augusto |e verfasserin |4 aut | |
| 700 | 1 | |a Mendonça, Ana Flávia |e verfasserin |4 aut | |
| 700 | 1 | |a de Macêdo, Isabel Luana |e verfasserin |4 aut | |
| 700 | 1 | |a Ribeiro de Sousa, Davi Emanuel |e verfasserin |4 aut | |
| 700 | 1 | |a Rodrigues de Toledo Costa, Gabriela |e verfasserin |4 aut | |
| 700 | 1 | |a Botelho de Castro, Marcio |e verfasserin |4 aut | |
| 700 | 1 | |a de Souza Andrade, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a de Abreu, Filipe Vieira Santos |e verfasserin |4 aut | |
| 700 | 1 | |a Campos, Fabrício Souza |e verfasserin |4 aut | |
| 700 | 1 | |a Iani, Felipe Campos de Melo |e verfasserin |4 aut | |
| 700 | 1 | |a Pereira, Maira Alves |e verfasserin |4 aut | |
| 700 | 1 | |a Cavalcante, Karina Ribeiro Leite Jardim |e verfasserin |4 aut | |
| 700 | 1 | |a de Freitas, Andre Ricardo Ribas |e verfasserin |4 aut | |
| 700 | 1 | |a Campelo de Albuquerque, Carlos Frederico |e verfasserin |4 aut | |
| 700 | 1 | |a Macário, Eduardo Marques |e verfasserin |4 aut | |
| 700 | 1 | |a Dos Anjos, Marlei Pickler Debiasi |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos, Rosane Campanher |e verfasserin |4 aut | |
| 700 | 1 | |a Campos, Aline Alves Scarpellini |e verfasserin |4 aut | |
| 700 | 1 | |a Pinter, Adriano |e verfasserin |4 aut | |
| 700 | 1 | |a Chame, Marcia |e verfasserin |4 aut | |
| 700 | 1 | |a Abdalla, Livia |e verfasserin |4 aut | |
| 700 | 1 | |a Riediger, Irina Nastassja |e verfasserin |4 aut | |
| 700 | 1 | |a Ribeiro, Sérvio Pontes |e verfasserin |4 aut | |
| 700 | 1 | |a Bento, Ana I |e verfasserin |4 aut | |
| 700 | 1 | |a de Oliveira, Tulio |e verfasserin |4 aut | |
| 700 | 1 | |a Freitas, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveira de Moura, Noely Fabiana |e verfasserin |4 aut | |
| 700 | 1 | |a Fabri, Allison |e verfasserin |4 aut | |
| 700 | 1 | |a Dos Santos Rodrigues, Cintia Damasceno |e verfasserin |4 aut | |
| 700 | 1 | |a Dos Santos, Carolina Cardoso |e verfasserin |4 aut | |
| 700 | 1 | |a Barreto de Almeida, Marco Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Dos Santos, Edmilson |e verfasserin |4 aut | |
| 700 | 1 | |a Cardoso, Jader |e verfasserin |4 aut | |
| 700 | 1 | |a Augusto, Douglas Adriano |e verfasserin |4 aut | |
| 700 | 1 | |a Krempser, Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Mucci, Luís Filipe |e verfasserin |4 aut | |
| 700 | 1 | |a Gatti, Renata Rispoli |e verfasserin |4 aut | |
| 700 | 1 | |a Cardoso, Sabrina Fernandes |e verfasserin |4 aut | |
| 700 | 1 | |a Fuck, João Augusto Brancher |e verfasserin |4 aut | |
| 700 | 1 | |a Lopes, Maria Goretti David |e verfasserin |4 aut | |
| 700 | 1 | |a Belmonte, Ivana Lucia |e verfasserin |4 aut | |
| 700 | 1 | |a Mayoral Pedroso da Silva, Gabriela |e verfasserin |4 aut | |
| 700 | 1 | |a Soares, Maiane Regina Ferreira |e verfasserin |4 aut | |
| 700 | 1 | |a de Castilhos, Marilia de Melo Santos |e verfasserin |4 aut | |
| 700 | 1 | |a de Souza E Silva, Joseana Cardoso |e verfasserin |4 aut | |
| 700 | 1 | |a Bisetto Junior, Alceu |e verfasserin |4 aut | |
| 700 | 1 | |a Pouzato, Emanuelle Gemin |e verfasserin |4 aut | |
| 700 | 1 | |a Tanabe, Laurina Setsuko |e verfasserin |4 aut | |
| 700 | 1 | |a Arita, Daniele Akemi |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuo, Ricardo |e verfasserin |4 aut | |
| 700 | 1 | |a Dos Santos Raymundo, Josiane |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Paula Cristina Linder |e verfasserin |4 aut | |
| 700 | 1 | |a Santana Araújo Ferreira Silva, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Samila, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Carvalho, Glauco |e verfasserin |4 aut | |
| 700 | 1 | |a Stabeli, Rodrigo |e verfasserin |4 aut | |
| 700 | 1 | |a Navegantes, Wildo |e verfasserin |4 aut | |
| 700 | 1 | |a Moreira, Luciano Andrade |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira, Alvaro Gil A |e verfasserin |4 aut | |
| 700 | 1 | |a Pinheiro, Guilherme Garcia |e verfasserin |4 aut | |
| 700 | 1 | |a Nunes, Bruno Tardelli Diniz |e verfasserin |4 aut | |
| 700 | 1 | |a de Almeida Medeiros, Daniele Barbosa |e verfasserin |4 aut | |
| 700 | 1 | |a Cruz, Ana Cecília Ribeiro |e verfasserin |4 aut | |
| 700 | 1 | |a Venâncio da Cunha, Rivaldo |e verfasserin |4 aut | |
| 700 | 1 | |a Van Voorhis, Wes |e verfasserin |4 aut | |
| 700 | 1 | |a Bispo de Filippis, Ana Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Almiron, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Holmes, Edward C |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos, Daniel Garkauskas |e verfasserin |4 aut | |
| 700 | 1 | |a Romano, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Lourenço, José |e verfasserin |4 aut | |
| 700 | 1 | |a Alcantara, Luiz Carlos Junior |e verfasserin |4 aut | |
| 700 | 1 | |a Duarte Dos Santos, Claudia Nunes |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Science advances |d 2015 |g 9(2023), 35 vom: 01. Sept., Seite eadg9204 |w (DE-627)NLM247717614 |x 2375-2548 |7 nnns |
| 773 | 1 | 8 | |g volume:9 |g year:2023 |g number:35 |g day:01 |g month:09 |g pages:eadg9204 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1126/sciadv.adg9204 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 9 |j 2023 |e 35 |b 01 |c 09 |h eadg9204 | ||