Chemical constituents of the marine-derived fungus Acremonium sp. AN-13
Two new compounds named 3(S)-hydroxy-1-(2,4,5-trihydroxy-3,6- dimethylphenyl)-hex-4E-en-1-one (1) and acremonilactone (2), together with nine known compounds (3-11), were isolated from the fermentation broth of Acremonium sp. associated with marine sediments collected from South China Sea. NMR and HRESIMS spectroscopic analysis elucidated the structure of two new compounds. Compound 2 had characteristic rotary gate shape skeleton with a six-membered lactone. Compounds 1 and 9 showed DPPH radical scavenging activity with inhibition rates of 96.50 and 85.95% at the concentration of 0.5 mg/ml, respectively. Moreover, compounds 4, 6 and 11 showed definite antibacterial activity against Staphylococcus aureus ATCC 6538.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Journal of Asian natural products research - 26(2024), 4 vom: 01. Apr., Seite 489-496 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
An, Chang-Liang [VerfasserIn] |
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| Links: |
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| Themen: |
Acremonium sp. |
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| Anmerkungen: |
Date Completed 08.04.2024 Date Revised 08.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/10286020.2023.2251114 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361404158 |
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| 520 | |a Two new compounds named 3(S)-hydroxy-1-(2,4,5-trihydroxy-3,6- dimethylphenyl)-hex-4E-en-1-one (1) and acremonilactone (2), together with nine known compounds (3-11), were isolated from the fermentation broth of Acremonium sp. associated with marine sediments collected from South China Sea. NMR and HRESIMS spectroscopic analysis elucidated the structure of two new compounds. Compound 2 had characteristic rotary gate shape skeleton with a six-membered lactone. Compounds 1 and 9 showed DPPH radical scavenging activity with inhibition rates of 96.50 and 85.95% at the concentration of 0.5 mg/ml, respectively. Moreover, compounds 4, 6 and 11 showed definite antibacterial activity against Staphylococcus aureus ATCC 6538 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acremonium sp. | |
| 650 | 4 | |a Marine sediment-derived fungi | |
| 650 | 4 | |a antioxidant and antibacterial activities | |
| 650 | 4 | |a secondary metabolites | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 700 | 1 | |a Ma, Qing-Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Qing-Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Yuan, Jing-Zhe |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Hao-Fu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, You-Xing |e verfasserin |4 aut | |
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