Pneumococcal pneumonia and endotoxemia : An experimental and clinical reappraisal
© 2023 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd..
BACKGROUND: Circulating endotoxins could result from bacterial digestive translocation during sepsis, thus contributing to uncontrolled systemic inflammation, leading in turn to organ dysfunction. We addressed this issue in the setting of severe pneumococcal pneumonia.
METHODS: Endotoxemia was measured in a clinically relevant rabbit model of ventilated pneumococcal pneumonia and in 110 patients with bacteraemic pneumonia, using a patented mass spectrometry (LC-MS/MS) method for detection of 3-OH fatty acids (C10, C12, C14, C16 and C18), which are molecules bound to the lipid A motif of LPS.
RESULTS: Whereas higher levels of systemic inflammation and organ dysfunctions were found, there was no significant difference in lipopolysaccharide concentrations when infected rabbits were compared to non-infected ones, or when patients were compared to healthy volunteers.
CONCLUSIONS: Seemingly, endotoxins do not drive the overwhelming inflammation associated with severe forms of pneumococcal pneumonia.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 2023 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
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| Enthalten in: |
European journal of clinical investigation - 54(2023), 1 vom: 12. Jan., Seite e14077 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Godon, Jeanne [VerfasserIn] |
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| Links: |
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| Themen: |
Endotoxemia |
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| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 16.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/eci.14077 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Pneumococcal pneumonia and endotoxemia |b An experimental and clinical reappraisal |
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| 500 | |a Date Revised 16.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: Circulating endotoxins could result from bacterial digestive translocation during sepsis, thus contributing to uncontrolled systemic inflammation, leading in turn to organ dysfunction. We addressed this issue in the setting of severe pneumococcal pneumonia | ||
| 520 | |a METHODS: Endotoxemia was measured in a clinically relevant rabbit model of ventilated pneumococcal pneumonia and in 110 patients with bacteraemic pneumonia, using a patented mass spectrometry (LC-MS/MS) method for detection of 3-OH fatty acids (C10, C12, C14, C16 and C18), which are molecules bound to the lipid A motif of LPS | ||
| 520 | |a RESULTS: Whereas higher levels of systemic inflammation and organ dysfunctions were found, there was no significant difference in lipopolysaccharide concentrations when infected rabbits were compared to non-infected ones, or when patients were compared to healthy volunteers | ||
| 520 | |a CONCLUSIONS: Seemingly, endotoxins do not drive the overwhelming inflammation associated with severe forms of pneumococcal pneumonia | ||
| 650 | 4 | |a Letter | |
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| 700 | 1 | |a Charles, Pierre-Emmanuel |e verfasserin |4 aut | |
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| 700 | 1 | |a Choubley, Hélène |e verfasserin |4 aut | |
| 700 | 1 | |a Jacquier, Marine |e verfasserin |4 aut | |
| 700 | 1 | |a Tetu, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Quenot, Jean-Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Luu, Maxime |e verfasserin |4 aut | |
| 700 | 1 | |a Binquet, Christine |e verfasserin |4 aut | |
| 700 | 1 | |a Masson, David |e verfasserin |4 aut | |
| 700 | 1 | |a Piroth, Lionel |e verfasserin |4 aut | |
| 700 | 1 | |a Blot, Mathieu |e verfasserin |4 aut | |
| 700 | 0 | |a Pneumotoxemia study group |e verfasserin |4 aut | |
| 700 | 1 | |a Croisier, Delphine |e investigator |4 oth | |
| 700 | 1 | |a Gohier, Sandrine |e investigator |4 oth | |
| 700 | 1 | |a Charles, Carole |e investigator |4 oth | |
| 700 | 1 | |a Guilloteau, Adrien |e investigator |4 oth | |
| 700 | 1 | |a Bardou, Marc |e investigator |4 oth | |
| 700 | 1 | |a Guezala, Ines Ben |e investigator |4 oth | |
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| 700 | 1 | |a Nguyen, Sylvie |e investigator |4 oth | |
| 700 | 1 | |a Gauthier, Thomas |e investigator |4 oth | |
| 700 | 1 | |a de Barros, Jean-Paul Pais |e investigator |4 oth | |
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| 700 | 1 | |a Bergas, Victoria |e investigator |4 oth | |
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| 700 | 1 | |a Tetu, Jennifer |e investigator |4 oth | |
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