Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles
Copyright © 2023 The Authors. Production and hosting by Elsevier B.V. All rights reserved..
Pulmonary vessels play a pivotal role in oxygen circulation. We previously demonstrated that pimaric acid (PiMA) activated large-conductance Ca2+-activated K+ (BKCa) channels and inhibited voltage-dependent Ca2+ channels (VDCCs). In the present study, PiMA attenuated vasoconstriction induced by high K+ or endothelin-1 in rat pulmonary arterial smooth muscles (PASMs). PiMA also reduced high K+-induced cytosolic [Ca2+] increase in PASM cells. PiMA increased BKCa currents and decreased VDCC currents. BKCa channels and VDCCs were formed by the α/β1 and α1C/α1D/β2/β3 subunits, respectively. These results indicate that PiMA induces vasorelaxation through the dual effects of BKCa channel activation and VDCC inhibition in PASMs.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:153 |
|---|---|
| Enthalten in: |
Journal of pharmacological sciences - 153(2023), 2 vom: 28. Okt., Seite 84-88 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ishida, Masashi [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
1C4QK22F9J |
|---|
| Anmerkungen: |
Date Completed 31.08.2023 Date Revised 31.08.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.jphs.2023.08.001 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM361384955 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM361384955 | ||
| 003 | DE-627 | ||
| 005 | 20231226085027.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jphs.2023.08.001 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1204.xml |
| 035 | |a (DE-627)NLM361384955 | ||
| 035 | |a (NLM)37640473 | ||
| 035 | |a (PII)S1347-8613(23)00045-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ishida, Masashi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 31.08.2023 | ||
| 500 | |a Date Revised 31.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Authors. Production and hosting by Elsevier B.V. All rights reserved. | ||
| 520 | |a Pulmonary vessels play a pivotal role in oxygen circulation. We previously demonstrated that pimaric acid (PiMA) activated large-conductance Ca2+-activated K+ (BKCa) channels and inhibited voltage-dependent Ca2+ channels (VDCCs). In the present study, PiMA attenuated vasoconstriction induced by high K+ or endothelin-1 in rat pulmonary arterial smooth muscles (PASMs). PiMA also reduced high K+-induced cytosolic [Ca2+] increase in PASM cells. PiMA increased BKCa currents and decreased VDCC currents. BKCa channels and VDCCs were formed by the α/β1 and α1C/α1D/β2/β3 subunits, respectively. These results indicate that PiMA induces vasorelaxation through the dual effects of BKCa channel activation and VDCC inhibition in PASMs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Ion channel | |
| 650 | 4 | |a Pimaric acid | |
| 650 | 4 | |a Pulmonary artery | |
| 650 | 7 | |a pimaric acid |2 NLM | |
| 650 | 7 | |a 88R98Z71NI |2 NLM | |
| 650 | 7 | |a Calcium Channels, L-Type |2 NLM | |
| 650 | 7 | |a Potassium Iodide |2 NLM | |
| 650 | 7 | |a 1C4QK22F9J |2 NLM | |
| 700 | 1 | |a Yamamura, Aya |e verfasserin |4 aut | |
| 700 | 1 | |a Fujiwara, Moe |e verfasserin |4 aut | |
| 700 | 1 | |a Amano, Taiki |e verfasserin |4 aut | |
| 700 | 1 | |a Ota, Mina |e verfasserin |4 aut | |
| 700 | 1 | |a Hikawa, Yukari |e verfasserin |4 aut | |
| 700 | 1 | |a Kondo, Rubii |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Yoshiaki |e verfasserin |4 aut | |
| 700 | 1 | |a Imaizumi, Yuji |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamura, Hisao |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of pharmacological sciences |d 2003 |g 153(2023), 2 vom: 28. Okt., Seite 84-88 |w (DE-627)NLM124584721 |x 1347-8648 |7 nnns |
| 773 | 1 | 8 | |g volume:153 |g year:2023 |g number:2 |g day:28 |g month:10 |g pages:84-88 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jphs.2023.08.001 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 153 |j 2023 |e 2 |b 28 |c 10 |h 84-88 | ||