Cellular heterogeneity and plasticity during NAFLD progression
Copyright © 2023 Park, Choi, Kim, Yang, An, Lee, Han, Lee, Kim, Bae and Oh..
Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma (HCC). NAFLD ranges from simple steatosis (or nonalcoholic fatty liver [NAFL]) to NASH as a progressive form of NAFL, which is characterized by steatosis, lobular inflammation, and hepatocellular ballooning with or without fibrosis. Because of the complex pathophysiological mechanism and the heterogeneity of NAFLD, including its wide spectrum of clinical and histological characteristics, no specific therapeutic drugs have been approved for NAFLD. The heterogeneity of NAFLD is closely associated with cellular plasticity, which describes the ability of cells to acquire new identities or change their phenotypes in response to environmental stimuli. The liver consists of parenchymal cells including hepatocytes and cholangiocytes and nonparenchymal cells including Kupffer cells, hepatic stellate cells, and endothelial cells, all of which have specialized functions. This heterogeneous cell population has cellular plasticity to adapt to environmental changes. During NAFLD progression, these cells can exert diverse and complex responses at multiple levels following exposure to a variety of stimuli, including fatty acids, inflammation, and oxidative stress. Therefore, this review provides insights into NAFLD heterogeneity by addressing the cellular plasticity and metabolic adaptation of hepatocytes, cholangiocytes, hepatic stellate cells, and Kupffer cells during NAFLD progression.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
|---|---|
| Enthalten in: |
Frontiers in molecular biosciences - 10(2023) vom: 23., Seite 1221669 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Park, Hyun-Ju [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cellular plasticity |
|---|
| Anmerkungen: |
Date Revised 29.08.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.3389/fmolb.2023.1221669 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM361340540 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM361340540 | ||
| 003 | DE-627 | ||
| 005 | 20231226084932.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fmolb.2023.1221669 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1204.xml |
| 035 | |a (DE-627)NLM361340540 | ||
| 035 | |a (NLM)37635938 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Park, Hyun-Ju |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cellular heterogeneity and plasticity during NAFLD progression |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 29.08.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2023 Park, Choi, Kim, Yang, An, Lee, Han, Lee, Kim, Bae and Oh. | ||
| 520 | |a Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma (HCC). NAFLD ranges from simple steatosis (or nonalcoholic fatty liver [NAFL]) to NASH as a progressive form of NAFL, which is characterized by steatosis, lobular inflammation, and hepatocellular ballooning with or without fibrosis. Because of the complex pathophysiological mechanism and the heterogeneity of NAFLD, including its wide spectrum of clinical and histological characteristics, no specific therapeutic drugs have been approved for NAFLD. The heterogeneity of NAFLD is closely associated with cellular plasticity, which describes the ability of cells to acquire new identities or change their phenotypes in response to environmental stimuli. The liver consists of parenchymal cells including hepatocytes and cholangiocytes and nonparenchymal cells including Kupffer cells, hepatic stellate cells, and endothelial cells, all of which have specialized functions. This heterogeneous cell population has cellular plasticity to adapt to environmental changes. During NAFLD progression, these cells can exert diverse and complex responses at multiple levels following exposure to a variety of stimuli, including fatty acids, inflammation, and oxidative stress. Therefore, this review provides insights into NAFLD heterogeneity by addressing the cellular plasticity and metabolic adaptation of hepatocytes, cholangiocytes, hepatic stellate cells, and Kupffer cells during NAFLD progression | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Cholangiocytes | |
| 650 | 4 | |a Kupffer cells | |
| 650 | 4 | |a NAFLD | |
| 650 | 4 | |a cellular plasticity | |
| 650 | 4 | |a hepatic stellate cells | |
| 650 | 4 | |a hepatocytes | |
| 650 | 4 | |a heterogeneity | |
| 650 | 4 | |a metabolic adaptation | |
| 700 | 1 | |a Choi, Juyoung |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Hyunmi |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Da-Yeon |e verfasserin |4 aut | |
| 700 | 1 | |a An, Tae Hyeon |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Eun-Woo |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Baek-Soo |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Sang Chul |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Won Kon |e verfasserin |4 aut | |
| 700 | 1 | |a Bae, Kwang-Hee |e verfasserin |4 aut | |
| 700 | 1 | |a Oh, Kyoung-Jin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in molecular biosciences |d 2014 |g 10(2023) vom: 23., Seite 1221669 |w (DE-627)NLM249149435 |x 2296-889X |7 nnns |
| 773 | 1 | 8 | |g volume:10 |g year:2023 |g day:23 |g pages:1221669 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3389/fmolb.2023.1221669 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 10 |j 2023 |b 23 |h 1221669 | ||