Aortic flow is associated with aging and exercise capacity
© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology..
Aims: Increased blood flow eccentricity in the aorta has been associated with aortic (AO) pathology, however, its association with exercise capacity has not been investigated. This study aimed to assess the relationships between flow eccentricity parameters derived from 2-dimensional (2D) phase-contrast (PC) cardiovascular magnetic resonance (CMR) imaging and aging and cardiopulmonary exercise test (CPET) in a cohort of healthy subjects.
Methods and Results: One hundred and sixty-nine healthy subjects (age 44 ± 13 years, M/F: 96/73) free of cardiovascular disease were recruited in a prospective study (NCT03217240) and underwent CMR, including 2D PC at an orthogonal plane just above the sinotubular junction, and CPET (cycle ergometer) within one week. The following AO flow parameters were derived: AO forward and backward flow indexed to body surface area (FFi, BFi), average flow displacement during systole (FDsavg), late systole (FDlsavg), diastole (FDdavg), systolic retrograde flow (SRF), systolic flow reversal ratio (sFRR), and pulse wave velocity (PWV). Exercise capacity was assessed by peak oxygen uptake (PVO2) from CPET. The mean values of FDsavg, FDlsavg, FDdavg, SRF, sFRR, and PWV were 17 ± 6%, 19 ± 8%, 29 ± 7%, 4.4 ± 4.2 mL, 5.9 ± 5.1%, and 4.3 ± 1.6 m/s, respectively. They all increased with age (r = 0.623, 0.628, 0.353, 0.590, 0.649, 0.598, all P < 0.0001), and decreased with PVO2 (r = -0.302, -0.270, -0.253, -0.149, -0.219, -0.161, all P < 0.05). A stepwise multivariable linear regression analysis using left ventricular ejection fraction (LVEF), FFi, and FDsavg showed an area under the curve of 0.769 in differentiating healthy subjects with high-risk exercise capacity (PVO2 ≤ 14 mL/kg/min).
Conclusion: AO flow haemodynamics change with aging and predict exercise capacity.
Registration: NCT03217240.
| Errataetall: |
CommentIn: Eur Heart J Open. 2023 Oct 26;3(5):oead105. - PMID 37901164 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:3 |
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| Enthalten in: |
European heart journal open - 3(2023), 4 vom: 16. Juli, Seite oead079 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhao, Xiaodan [VerfasserIn] |
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| Links: |
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| Themen: |
2D phase-contrast |
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| Anmerkungen: |
Date Revised 12.02.2024 published: Electronic-eCollection ClinicalTrials.gov: NCT03217240 CommentIn: Eur Heart J Open. 2023 Oct 26;3(5):oead105. - PMID 37901164 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1093/ehjopen/oead079 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Aortic flow is associated with aging and exercise capacity |
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| 500 | |a Date Revised 12.02.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a ClinicalTrials.gov: NCT03217240 | ||
| 500 | |a CommentIn: Eur Heart J Open. 2023 Oct 26;3(5):oead105. - PMID 37901164 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. | ||
| 520 | |a Aims: Increased blood flow eccentricity in the aorta has been associated with aortic (AO) pathology, however, its association with exercise capacity has not been investigated. This study aimed to assess the relationships between flow eccentricity parameters derived from 2-dimensional (2D) phase-contrast (PC) cardiovascular magnetic resonance (CMR) imaging and aging and cardiopulmonary exercise test (CPET) in a cohort of healthy subjects | ||
| 520 | |a Methods and Results: One hundred and sixty-nine healthy subjects (age 44 ± 13 years, M/F: 96/73) free of cardiovascular disease were recruited in a prospective study (NCT03217240) and underwent CMR, including 2D PC at an orthogonal plane just above the sinotubular junction, and CPET (cycle ergometer) within one week. The following AO flow parameters were derived: AO forward and backward flow indexed to body surface area (FFi, BFi), average flow displacement during systole (FDsavg), late systole (FDlsavg), diastole (FDdavg), systolic retrograde flow (SRF), systolic flow reversal ratio (sFRR), and pulse wave velocity (PWV). Exercise capacity was assessed by peak oxygen uptake (PVO2) from CPET. The mean values of FDsavg, FDlsavg, FDdavg, SRF, sFRR, and PWV were 17 ± 6%, 19 ± 8%, 29 ± 7%, 4.4 ± 4.2 mL, 5.9 ± 5.1%, and 4.3 ± 1.6 m/s, respectively. They all increased with age (r = 0.623, 0.628, 0.353, 0.590, 0.649, 0.598, all P < 0.0001), and decreased with PVO2 (r = -0.302, -0.270, -0.253, -0.149, -0.219, -0.161, all P < 0.05). A stepwise multivariable linear regression analysis using left ventricular ejection fraction (LVEF), FFi, and FDsavg showed an area under the curve of 0.769 in differentiating healthy subjects with high-risk exercise capacity (PVO2 ≤ 14 mL/kg/min) | ||
| 520 | |a Conclusion: AO flow haemodynamics change with aging and predict exercise capacity | ||
| 520 | |a Registration: NCT03217240 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 2D phase-contrast | |
| 650 | 4 | |a Aortic flow | |
| 650 | 4 | |a Cardiopulmonary exercise testing | |
| 650 | 4 | |a Flow displacement | |
| 650 | 4 | |a Haemodynamics | |
| 700 | 1 | |a Garg, Pankaj |e verfasserin |4 aut | |
| 700 | 1 | |a Assadi, Hosamadin |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Ru-San |e verfasserin |4 aut | |
| 700 | 1 | |a Chai, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Yeo, Tee Joo |e verfasserin |4 aut | |
| 700 | 1 | |a Matthews, Gareth |e verfasserin |4 aut | |
| 700 | 1 | |a Mehmood, Zia |e verfasserin |4 aut | |
| 700 | 1 | |a Leng, Shuang |e verfasserin |4 aut | |
| 700 | 1 | |a Bryant, Jennifer Ann |e verfasserin |4 aut | |
| 700 | 1 | |a Teo, Lynette L S |e verfasserin |4 aut | |
| 700 | 1 | |a Ong, Ching Ching |e verfasserin |4 aut | |
| 700 | 1 | |a Yip, James W |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Ju Le |e verfasserin |4 aut | |
| 700 | 1 | |a van der Geest, Rob J |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Liang |e verfasserin |4 aut | |
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