The association between exocrine pancreatic dysfunction and insulin resistance in an insulin-resistant population in Turkey : A cross-sectional study
Background: In insulin resistance (IR), it is thought that pancreatic fat accumulation may decrease pancreatic volume, cause an impaired endocrine function, and simultaneously lead to an exocrine dysfunction before diabetes develops.
Aim: The association between pancreatic exocrine function and insulin resistance (IR) was assessed in a population with insulin resistance.
Method: This was a descriptive cross-sectional study that included 43 IR cases with no other comorbid diseases or pregnancy and 41 healthy controls. Fasting blood adiponectin, leptin, pancreatic amylase, lipase, and stool fecal elastase-1 (FE-1) were studied and compared in both groups.
Results: The IR group consisted of 38 females (88.3%) and five males (11.6%), while the control group consisted of 31 females (75.6%) and ten males (24.3%). FE-1 levels were significantly lower in the IR group (P-value <0.01). Blood glucose, insulin, and HbA1c levels were significantly higher in the IR group than in the control (P-value of <0.01, <0.01, <0.01, respectively). Leptin levels were significantly higher in the IR group compared to the controls (P-value = 0.013). After dividing the whole group (n: 84) into two groups as FE-1 <200 μg/g (n: 61) and FE-1 ≥200 μg/g (n: 23), logistic regression analysis was performed; the significant predictor of low FE-1 was HOMA-IR (ODD ratio: 4.27, P-value <0.01, 95% confidence interval for ODD ratio: 1.95-9.30).
Conclusion: This study showed that IR is associated with pancreatic exocrine dysfunction.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Nigerian journal of clinical practice - 26(2023), 8 vom: 01. Aug., Seite 1051-1056 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yildiz, S [VerfasserIn] |
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| Links: |
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| Themen: |
Fecal elastase 1 |
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| Anmerkungen: |
Date Completed 12.09.2023 Date Revised 12.09.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.4103/njcp.njcp_1451_21 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361337108 |
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| 100 | 1 | |a Yildiz, S |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The association between exocrine pancreatic dysfunction and insulin resistance in an insulin-resistant population in Turkey |b A cross-sectional study |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 12.09.2023 | ||
| 500 | |a Date Revised 12.09.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Background: In insulin resistance (IR), it is thought that pancreatic fat accumulation may decrease pancreatic volume, cause an impaired endocrine function, and simultaneously lead to an exocrine dysfunction before diabetes develops | ||
| 520 | |a Aim: The association between pancreatic exocrine function and insulin resistance (IR) was assessed in a population with insulin resistance | ||
| 520 | |a Method: This was a descriptive cross-sectional study that included 43 IR cases with no other comorbid diseases or pregnancy and 41 healthy controls. Fasting blood adiponectin, leptin, pancreatic amylase, lipase, and stool fecal elastase-1 (FE-1) were studied and compared in both groups | ||
| 520 | |a Results: The IR group consisted of 38 females (88.3%) and five males (11.6%), while the control group consisted of 31 females (75.6%) and ten males (24.3%). FE-1 levels were significantly lower in the IR group (P-value <0.01). Blood glucose, insulin, and HbA1c levels were significantly higher in the IR group than in the control (P-value of <0.01, <0.01, <0.01, respectively). Leptin levels were significantly higher in the IR group compared to the controls (P-value = 0.013). After dividing the whole group (n: 84) into two groups as FE-1 <200 μg/g (n: 61) and FE-1 ≥200 μg/g (n: 23), logistic regression analysis was performed; the significant predictor of low FE-1 was HOMA-IR (ODD ratio: 4.27, P-value <0.01, 95% confidence interval for ODD ratio: 1.95-9.30) | ||
| 520 | |a Conclusion: This study showed that IR is associated with pancreatic exocrine dysfunction | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Fecal elastase 1 | |
| 650 | 4 | |a Insulin resistance | |
| 650 | 4 | |a Pancreatic exocrine dysfunction | |
| 650 | 7 | |a Insulin |2 NLM | |
| 650 | 7 | |a Leptin |2 NLM | |
| 700 | 1 | |a Sonmez, G M |e verfasserin |4 aut | |
| 700 | 1 | |a Komuroglu, A U |e verfasserin |4 aut | |
| 700 | 1 | |a Alay, M |e verfasserin |4 aut | |
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