Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment
© 2023. The Korean Society for Biomaterials..
BACKGROUND: Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their application in various research areas, particularly in diagnostics and therapy.
MAIN BODY: Exosomes have great potential as biomarkers and delivery vehicles for encapsulating therapeutic cargo. However, the limitations of bare exosomes, such as rapid phagocytic clearance and non-specific biodistribution after injection, pose significant challenges to their application as drug delivery systems. This review focuses on exosome-based drug delivery for treating rheumatoid arthritis, emphasizing pre/post-engineering approaches to overcome these challenges.
CONCLUSION: This review will serve as an essential resource for future studies to develop novel exosome-based therapeutic approaches for rheumatoid arthritis. Overall, the review highlights the potential of exosomes as a promising therapeutic approach for rheumatoid arthritis treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Biomaterials research - 27(2023), 1 vom: 28. Aug., Seite 81 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Eun Sook [VerfasserIn] |
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| Links: |
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| Themen: |
Disease microenvironment |
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| Anmerkungen: |
Date Revised 20.11.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1186/s40824-023-00418-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361333722 |
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| 500 | |a Date Revised 20.11.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023. The Korean Society for Biomaterials. | ||
| 520 | |a BACKGROUND: Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their application in various research areas, particularly in diagnostics and therapy | ||
| 520 | |a MAIN BODY: Exosomes have great potential as biomarkers and delivery vehicles for encapsulating therapeutic cargo. However, the limitations of bare exosomes, such as rapid phagocytic clearance and non-specific biodistribution after injection, pose significant challenges to their application as drug delivery systems. This review focuses on exosome-based drug delivery for treating rheumatoid arthritis, emphasizing pre/post-engineering approaches to overcome these challenges | ||
| 520 | |a CONCLUSION: This review will serve as an essential resource for future studies to develop novel exosome-based therapeutic approaches for rheumatoid arthritis. Overall, the review highlights the potential of exosomes as a promising therapeutic approach for rheumatoid arthritis treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Disease microenvironment | |
| 650 | 4 | |a Engineered exosome | |
| 650 | 4 | |a Exosome | |
| 650 | 4 | |a Rheumatoid arthritis | |
| 700 | 1 | |a Ko, Hyewon |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Chan Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Hyun-Chul |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Seong-Kyoon |e verfasserin |4 aut | |
| 700 | 1 | |a Jeong, Sang Won |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Se-Guen |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Sung-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Na, Hee-Kyung |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Jae Hyung |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Jung Min |e verfasserin |4 aut | |
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