Expression of HOXA10 Gene in Women with Endometriosis : A Systematic Review
The homeobox A10 (HOXA10) gene is known to be related to endometriosis; however, due to a lack of knowledge/evidence in the pathogenesis of endometriosis, the mechanisms that link HOXA10 to endometriosis still need to be clarified. This review addresses the difference in the expression of the HOXA10 gene in endometriotic women versus non-endometriotic women across populations by country and discusses its influences on women's fertility. An organized search of electronic databases was conducted in Scopus, ScienceDirect, PubMed, and Web of Science. The keywords used were (HOXA10 OR "homeobox A10" OR PL OR HOX1 OR HOX1H OR HOX1.8) AND ("gene expression") AND (endometriosis). The initial search resulted in 623 articles, 10 of which were included in this review. All ten papers included in this study were rated fair in terms of the quality of the studies conducted. The expression of the HOXA10 gene was found to be downregulated in most studies. However, one study provided evidence of the downregulation and upregulation of HOXA10 gene expression due to the localization of endometriotic lesions. Measuring the expression of the HOXA10 gene in women is clinically essential to predicting endometriosis, endometrial receptivity, and the development of pinopodes in the endometrium during the luteal phase.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
|---|---|
| Enthalten in: |
International journal of molecular sciences - 24(2023), 16 vom: 17. Aug. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lazim, Nurunnajah [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
140441-81-2 |
|---|
| Anmerkungen: |
Date Completed 28.08.2023 Date Revised 30.08.2023 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.3390/ijms241612869 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM361272324 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM361272324 | ||
| 003 | DE-627 | ||
| 005 | 20231226084806.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ijms241612869 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1204.xml |
| 035 | |a (DE-627)NLM361272324 | ||
| 035 | |a (NLM)37629050 | ||
| 035 | |a (PII)12869 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Lazim, Nurunnajah |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Expression of HOXA10 Gene in Women with Endometriosis |b A Systematic Review |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 28.08.2023 | ||
| 500 | |a Date Revised 30.08.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The homeobox A10 (HOXA10) gene is known to be related to endometriosis; however, due to a lack of knowledge/evidence in the pathogenesis of endometriosis, the mechanisms that link HOXA10 to endometriosis still need to be clarified. This review addresses the difference in the expression of the HOXA10 gene in endometriotic women versus non-endometriotic women across populations by country and discusses its influences on women's fertility. An organized search of electronic databases was conducted in Scopus, ScienceDirect, PubMed, and Web of Science. The keywords used were (HOXA10 OR "homeobox A10" OR PL OR HOX1 OR HOX1H OR HOX1.8) AND ("gene expression") AND (endometriosis). The initial search resulted in 623 articles, 10 of which were included in this review. All ten papers included in this study were rated fair in terms of the quality of the studies conducted. The expression of the HOXA10 gene was found to be downregulated in most studies. However, one study provided evidence of the downregulation and upregulation of HOXA10 gene expression due to the localization of endometriotic lesions. Measuring the expression of the HOXA10 gene in women is clinically essential to predicting endometriosis, endometrial receptivity, and the development of pinopodes in the endometrium during the luteal phase | ||
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a HOX | |
| 650 | 4 | |a HOXA10 | |
| 650 | 4 | |a endometriosis | |
| 650 | 4 | |a endometrium | |
| 650 | 4 | |a gene | |
| 650 | 4 | |a gene expression | |
| 650 | 7 | |a antineoplaston A10 |2 NLM | |
| 650 | 7 | |a 16VY3TM7ZO |2 NLM | |
| 650 | 7 | |a Benzeneacetamides |2 NLM | |
| 650 | 7 | |a HOXA10 protein, human |2 NLM | |
| 650 | 7 | |a 140441-81-2 |2 NLM | |
| 650 | 7 | |a Homeobox A10 Proteins |2 NLM | |
| 700 | 1 | |a Elias, Marjanu Hikmah |e verfasserin |4 aut | |
| 700 | 1 | |a Sutaji, Zulazmi |e verfasserin |4 aut | |
| 700 | 1 | |a Abdul Karim, Abdul Kadir |e verfasserin |4 aut | |
| 700 | 1 | |a Abu, Mohammad Azrai |e verfasserin |4 aut | |
| 700 | 1 | |a Ugusman, Azizah |e verfasserin |4 aut | |
| 700 | 1 | |a Syafruddin, Saiful Effendi |e verfasserin |4 aut | |
| 700 | 1 | |a Mokhtar, Mohd Helmy |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmad, Mohd Faizal |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of molecular sciences |d 2008 |g 24(2023), 16 vom: 17. Aug. |w (DE-627)NLM185552161 |x 1422-0067 |7 nnns |
| 773 | 1 | 8 | |g volume:24 |g year:2023 |g number:16 |g day:17 |g month:08 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/ijms241612869 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 24 |j 2023 |e 16 |b 17 |c 08 | ||