Protective action of Cecropia pachystachya extract and enriched flavonoid fraction against memory deficits, inflammation and oxidative damage in lipopolysaccharide challenged mice
Copyright © 2023 Elsevier B.V. All rights reserved..
ETHNOPHARMACOLOGICAL RELEVANCE: Cecropia pachystachya (CP) Trécul is a medicinal plant native to South and Central America with several pharmacological properties, such as anti-inflammatory and neuroprotective.
AIM OF THE STUDY: In this study, we investigated the effect of CP extract (200 mg/kg) and its enriched flavonoid fraction (EFF-CP) (50 and 100 mg/kg) in a model of lipopolysaccharide (LPS)-induced neuroinflammation.
MATERIAL AND METHODS: CP and EFF-CP were administered intragastrically for 14 days and LPS (250 μg/kg) was administered intraperitoneally from the 8th to the 14th days. LC/DAD/MS analysis showed the presence of isoorientin, orientin, and isovitexin as major compounds.
RESULTS: The results demonstrated that CP extract and EFF-CP gave protection against LPS-induced short-term and long-term memory deficits. The treatment with CP and/or EFF-CP protected against LPS-induced increases in reactive species, nitrites, total thiol and lipoperoxidation in the cerebral cortex, hippocampus and striatum. Moreover, CP and EFF-CP restored superoxide dismutase and catalase activities that had been reduced by LPS in the cerebral cortex, hippocampus and striatum. TNF-α levels were increased in the cortex, striatum and hippocampus in the LPS group, while CP treatment prevented this change in the cerebral cortex. EFF-CP decreased the levels of this cytokine in all structures analyzed at both doses.
CONCLUSION: CP extract and its EFF-CP are important therapeutic targets for the management of neuroinflammation observed in neurodegenerative diseases.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 2023 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:318 |
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Enthalten in: |
Journal of ethnopharmacology - 318(2023), Pt B vom: 10. Jan., Seite 117080 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Bona, Natália Pontes [VerfasserIn] |
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Links: |
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Themen: |
Cecropia pachystachya |
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Anmerkungen: |
Date Completed 18.09.2023 Date Revised 18.09.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.jep.2023.117080 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM361238053 |
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520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
520 | |a ETHNOPHARMACOLOGICAL RELEVANCE: Cecropia pachystachya (CP) Trécul is a medicinal plant native to South and Central America with several pharmacological properties, such as anti-inflammatory and neuroprotective | ||
520 | |a AIM OF THE STUDY: In this study, we investigated the effect of CP extract (200 mg/kg) and its enriched flavonoid fraction (EFF-CP) (50 and 100 mg/kg) in a model of lipopolysaccharide (LPS)-induced neuroinflammation | ||
520 | |a MATERIAL AND METHODS: CP and EFF-CP were administered intragastrically for 14 days and LPS (250 μg/kg) was administered intraperitoneally from the 8th to the 14th days. LC/DAD/MS analysis showed the presence of isoorientin, orientin, and isovitexin as major compounds | ||
520 | |a RESULTS: The results demonstrated that CP extract and EFF-CP gave protection against LPS-induced short-term and long-term memory deficits. The treatment with CP and/or EFF-CP protected against LPS-induced increases in reactive species, nitrites, total thiol and lipoperoxidation in the cerebral cortex, hippocampus and striatum. Moreover, CP and EFF-CP restored superoxide dismutase and catalase activities that had been reduced by LPS in the cerebral cortex, hippocampus and striatum. TNF-α levels were increased in the cortex, striatum and hippocampus in the LPS group, while CP treatment prevented this change in the cerebral cortex. EFF-CP decreased the levels of this cytokine in all structures analyzed at both doses | ||
520 | |a CONCLUSION: CP extract and its EFF-CP are important therapeutic targets for the management of neuroinflammation observed in neurodegenerative diseases | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Cecropia pachystachya | |
650 | 4 | |a Flavonoids | |
650 | 4 | |a Lipopolysaccharide | |
650 | 4 | |a Memory | |
650 | 4 | |a Neuroinflammation | |
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700 | 1 | |a Saraiva, Juliane Torchelsen |e verfasserin |4 aut | |
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