Radiation-induced dormancy of intracerebral melanoma : endotoxin inflammation leads to both shortened tumor dormancy and long-term survival with localized senescence
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
Radiation therapy (RT) treats approximately half of all cancers and most brain cancers. RT is variably effective at inducing a dormant tumor state i.e. the time between RT and clinical recurrence of tumor growth. Interventions that significantly lengthen tumor dormancy would improve long-term outcomes. Inflammation can promote the escape of experimental tumors from metastatic dormancy in the lung. Previously we showed intracerebral B16F10 melanoma dormancy varied with RT dose; 20.5 Gy induced dormancy lasted ~ 2 to 4 weeks-sufficient time to study escape from dormancy. Tumors were followed over time using bioluminescence. Surprisingly, some tumors in endotoxin-treated mice exited from dormancy slower; a large fraction of the mice survived more than 1-year. A cohort of mice also experienced an accelerated exit from dormancy and increased mortality indicating there might be variation within the tumor or inflammatory microenvironment that leads to both an early deleterious effect and a longer-term protective effect of inflammation. Some of the melanin containing cells at the site of the original tumor were positive for senescent markers p16, p21 and βGal. Changes in some cytokine/chemokine levels in blood were also detected. Follow-up studies are needed to identify cytokines/chemokines or other mechanisms that promote long-term dormancy after RT.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:72 |
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| Enthalten in: |
Cancer immunology, immunotherapy : CII - 72(2023), 11 vom: 10. Nov., Seite 3851-3859 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ridwan, Sharif M [VerfasserIn] |
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| Links: |
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| Themen: |
Endotoxin inflammation |
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| Anmerkungen: |
Date Completed 20.11.2023 Date Revised 26.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00262-023-03481-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 245 | 1 | 0 | |a Radiation-induced dormancy of intracerebral melanoma |b endotoxin inflammation leads to both shortened tumor dormancy and long-term survival with localized senescence |
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| 520 | |a © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a Radiation therapy (RT) treats approximately half of all cancers and most brain cancers. RT is variably effective at inducing a dormant tumor state i.e. the time between RT and clinical recurrence of tumor growth. Interventions that significantly lengthen tumor dormancy would improve long-term outcomes. Inflammation can promote the escape of experimental tumors from metastatic dormancy in the lung. Previously we showed intracerebral B16F10 melanoma dormancy varied with RT dose; 20.5 Gy induced dormancy lasted ~ 2 to 4 weeks-sufficient time to study escape from dormancy. Tumors were followed over time using bioluminescence. Surprisingly, some tumors in endotoxin-treated mice exited from dormancy slower; a large fraction of the mice survived more than 1-year. A cohort of mice also experienced an accelerated exit from dormancy and increased mortality indicating there might be variation within the tumor or inflammatory microenvironment that leads to both an early deleterious effect and a longer-term protective effect of inflammation. Some of the melanin containing cells at the site of the original tumor were positive for senescent markers p16, p21 and βGal. Changes in some cytokine/chemokine levels in blood were also detected. Follow-up studies are needed to identify cytokines/chemokines or other mechanisms that promote long-term dormancy after RT | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Endotoxin inflammation | |
| 650 | 4 | |a Intra-cerebral melanoma | |
| 650 | 4 | |a Radiation-induced dormancy | |
| 650 | 4 | |a Senescence | |
| 650 | 4 | |a Tumor dormancy | |
| 700 | 1 | |a Emlein, Rose |e verfasserin |4 aut | |
| 700 | 1 | |a Mesbahi, Asghar |e verfasserin |4 aut | |
| 700 | 1 | |a Annabi, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Hainfeld, James F |e verfasserin |4 aut | |
| 700 | 1 | |a Smilowitz, Henry M |e verfasserin |4 aut | |
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