A Biodegradable, Adhesive, and Stretchable Hydrogel and Potential Applications for Allergic Rhinitis and Epistaxis
© 2023 Wiley-VCH GmbH..
Bioadhesive hydrogels have attracted considerable attention as innovative materials in medical interventions and human-machine interface engineering. Despite significant advances in their application, it remains critical to develop adhesive hydrogels that meet the requirements for biocompatibility, biodegradability, long-term strong adhesion, and efficient drug delivery vehicles in moist conditions. A biocompatible, biodegradable, soft, and stretchable hydrogel made from a combination of a biopolymer (unmodified natural gelatin) and stretchable biodegradable poly(ethylene glycol) diacrylate is proposed to achieve durable and tough adhesion and explore its use for convenient and effective intranasal hemostasis and drug administration. Desirable hemostasis efficacy and enhanced therapeutic outcomes for allergic rhinitis are accomplished. Biodegradation enables the spontaneous removal of materials without causing secondary damage and minimizes medical waste. Preliminary trials on human subjects provide an essential foundation for practical applications. This work elucidates material strategies for biodegradable adhesive hydrogels, which are critical to achieving robust material interfaces and advanced drug delivery platforms for novel clinical treatments.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
Advanced healthcare materials - 12(2023), 29 vom: 23. Nov., Seite e2302059 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Liu, Shengnan [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Adhesive hydrogels |
|---|
| Anmerkungen: |
Date Completed 27.11.2023 Date Revised 06.12.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1002/adhm.202302059 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM361084927 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM361084927 | ||
| 003 | DE-627 | ||
| 005 | 20231226084409.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/adhm.202302059 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1203.xml |
| 035 | |a (DE-627)NLM361084927 | ||
| 035 | |a (NLM)37610041 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Liu, Shengnan |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A Biodegradable, Adhesive, and Stretchable Hydrogel and Potential Applications for Allergic Rhinitis and Epistaxis |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 27.11.2023 | ||
| 500 | |a Date Revised 06.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 Wiley-VCH GmbH. | ||
| 520 | |a Bioadhesive hydrogels have attracted considerable attention as innovative materials in medical interventions and human-machine interface engineering. Despite significant advances in their application, it remains critical to develop adhesive hydrogels that meet the requirements for biocompatibility, biodegradability, long-term strong adhesion, and efficient drug delivery vehicles in moist conditions. A biocompatible, biodegradable, soft, and stretchable hydrogel made from a combination of a biopolymer (unmodified natural gelatin) and stretchable biodegradable poly(ethylene glycol) diacrylate is proposed to achieve durable and tough adhesion and explore its use for convenient and effective intranasal hemostasis and drug administration. Desirable hemostasis efficacy and enhanced therapeutic outcomes for allergic rhinitis are accomplished. Biodegradation enables the spontaneous removal of materials without causing secondary damage and minimizes medical waste. Preliminary trials on human subjects provide an essential foundation for practical applications. This work elucidates material strategies for biodegradable adhesive hydrogels, which are critical to achieving robust material interfaces and advanced drug delivery platforms for novel clinical treatments | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a adhesive hydrogels | |
| 650 | 4 | |a allergic rhinitis | |
| 650 | 4 | |a biodegradability | |
| 650 | 4 | |a epistaxis | |
| 650 | 4 | |a stretchability | |
| 650 | 7 | |a Hydrogels |2 NLM | |
| 650 | 7 | |a Adhesives |2 NLM | |
| 650 | 7 | |a poly(ethylene glycol)diacrylate |2 NLM | |
| 700 | 1 | |a Yu, Qianru |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Kuntao |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Jiao |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Zhenhu |e verfasserin |4 aut | |
| 700 | 1 | |a He, Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Lan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yunxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Bozhen |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Sheng, Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Jiahua |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Lingyun |e verfasserin |4 aut | |
| 700 | 1 | |a Qi, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Yin, Lan |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Advanced healthcare materials |d 2012 |g 12(2023), 29 vom: 23. Nov., Seite e2302059 |w (DE-627)NLM218710070 |x 2192-2659 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2023 |g number:29 |g day:23 |g month:11 |g pages:e2302059 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/adhm.202302059 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2023 |e 29 |b 23 |c 11 |h e2302059 | ||