Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets
CONTEXT: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still ongoing and currently the most striking epidemic disease. With the rapid global spread of SARS-CoV-2 variants, new antivirals are urgently needed to avert a more serious crisis. Inhibitors from traditional medicines or natural plants have shown promising results to fight COVID-19 with different mechanisms of action.
OBJECTIVES: To provide comprehensive and promising approaches to the medical community in the fight against this epidemic by reviewing potential plant-derived anti-SARS-CoV-2 inhibitors.
METHODS: Structural databases such as TCMSP (http://lsp.nwu.edu.cn/tcmsp.php), TCM Database Taiwan (http://tcm.cmu.edu.tw/), BATMAN-TCM (http://bionet.ncpsb.org/batman-tcm/) and TCMID (http://www.megabionet.org/tcmid/), as well as PubMed, Sci Finder, Research Gate, Science Direct, CNKI, Web of Science and Google Scholar were searched for relevant articles on TCMs and natural products against SARS-CoV-2.
RESULTS: Seven traditional Chinese medicines formulas have unique advantages in regulating the immune system for treating COVID-19. The plant-derived natural compounds as anti-SARS-CoV-2 inhibitors were identified based on 5 SARS-CoV-2 key proteins, namely, angiotensin-converting enzyme 2 (ACE2), 3 C-like protease (3CLpro), papain-like protease (PLpro), spike (S) protein, and nucleocapsid (N) protein.
CONCLUSIONS: A variety of natural products, such as flavonoids, terpenoids, phenols, and alkaloids, were identified, which could be used as potential SASR-Cov-2 inhibitors. These shed new light on the efficient discovery of SASR-Cov-2 inhibitors from natural products.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
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| Enthalten in: |
Pharmaceutical biology - 61(2023), 1 vom: 22. Dez., Seite 1186-1210 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
He, Zhouman [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-SARS-CoV-2 strategies |
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| Anmerkungen: |
Date Completed 23.08.2023 Date Revised 25.08.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1080/13880209.2023.2241518 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a CONTEXT: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still ongoing and currently the most striking epidemic disease. With the rapid global spread of SARS-CoV-2 variants, new antivirals are urgently needed to avert a more serious crisis. Inhibitors from traditional medicines or natural plants have shown promising results to fight COVID-19 with different mechanisms of action | ||
| 520 | |a OBJECTIVES: To provide comprehensive and promising approaches to the medical community in the fight against this epidemic by reviewing potential plant-derived anti-SARS-CoV-2 inhibitors | ||
| 520 | |a METHODS: Structural databases such as TCMSP (http://lsp.nwu.edu.cn/tcmsp.php), TCM Database Taiwan (http://tcm.cmu.edu.tw/), BATMAN-TCM (http://bionet.ncpsb.org/batman-tcm/) and TCMID (http://www.megabionet.org/tcmid/), as well as PubMed, Sci Finder, Research Gate, Science Direct, CNKI, Web of Science and Google Scholar were searched for relevant articles on TCMs and natural products against SARS-CoV-2 | ||
| 520 | |a RESULTS: Seven traditional Chinese medicines formulas have unique advantages in regulating the immune system for treating COVID-19. The plant-derived natural compounds as anti-SARS-CoV-2 inhibitors were identified based on 5 SARS-CoV-2 key proteins, namely, angiotensin-converting enzyme 2 (ACE2), 3 C-like protease (3CLpro), papain-like protease (PLpro), spike (S) protein, and nucleocapsid (N) protein | ||
| 520 | |a CONCLUSIONS: A variety of natural products, such as flavonoids, terpenoids, phenols, and alkaloids, were identified, which could be used as potential SASR-Cov-2 inhibitors. These shed new light on the efficient discovery of SASR-Cov-2 inhibitors from natural products | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a anti-SARS-CoV-2 strategies | |
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| 650 | 4 | |a traditional chinese medicines | |
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| 700 | 1 | |a Yuan, Jia |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yuanwen |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Runfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Mo, Meilan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yutao |e verfasserin |4 aut | |
| 700 | 1 | |a Ti, Huihui |e verfasserin |4 aut | |
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