Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
© 2023 The Author(s)..
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs).
Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality.
Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions.
Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51).
Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
---|---|
Enthalten in: |
Research and practice in thrombosis and haemostasis - 7(2023), 5 vom: 01. Juli, Seite 102142 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Griffee, Matthew J [VerfasserIn] |
---|
Links: |
---|
Themen: |
COVID-19 |
---|
Anmerkungen: |
Date Revised 20.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.1016/j.rpth.2023.102142 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM360997589 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM360997589 | ||
003 | DE-627 | ||
005 | 20240320233350.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.rpth.2023.102142 |2 doi | |
028 | 5 | 2 | |a pubmed24n1337.xml |
035 | |a (DE-627)NLM360997589 | ||
035 | |a (NLM)37601011 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Griffee, Matthew J |e verfasserin |4 aut | |
245 | 1 | 0 | |a Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 20.03.2024 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a © 2023 The Author(s). | ||
520 | |a Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs) | ||
520 | |a Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality | ||
520 | |a Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions | ||
520 | |a Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51) | ||
520 | |a Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a developing countries | |
650 | 4 | |a disseminated intravascular coagulation | |
650 | 4 | |a hemorrhage | |
650 | 4 | |a ischemic stroke | |
650 | 4 | |a thromboembolism | |
650 | 4 | |a thrombosis | |
700 | 1 | |a Bozza, Patricia T |e verfasserin |4 aut | |
700 | 1 | |a Reyes, Luis Felipe |e verfasserin |4 aut | |
700 | 1 | |a Eddington, Devin P |e verfasserin |4 aut | |
700 | 1 | |a Rosenberger, Dorothea |e verfasserin |4 aut | |
700 | 1 | |a Merson, Laura |e verfasserin |4 aut | |
700 | 1 | |a Citarella, Barbara Wanjiru |e verfasserin |4 aut | |
700 | 1 | |a Fanning, Jonathon P |e verfasserin |4 aut | |
700 | 1 | |a Alexander, Peta M A |e verfasserin |4 aut | |
700 | 1 | |a Fraser, John |e verfasserin |4 aut | |
700 | 1 | |a Dalton, Heidi |e verfasserin |4 aut | |
700 | 1 | |a Cho, Sung-Min |e verfasserin |4 aut | |
700 | 0 | |a ISARIC Clinical Characterisation Group |e verfasserin |4 aut | |
700 | 1 | |a Abdukahil, Sheryl Ann |e investigator |4 oth | |
700 | 1 | |a Abdulkadir, Nurul Najmee |e investigator |4 oth | |
700 | 1 | |a Abe, Ryuzo |e investigator |4 oth | |
700 | 1 | |a Abel, Laurent |e investigator |4 oth | |
700 | 1 | |a Abrous, Amal |e investigator |4 oth | |
700 | 1 | |a Absil, Lara |e investigator |4 oth | |
700 | 1 | |a Acker, Andrew |e investigator |4 oth | |
700 | 1 | |a Adam, Elisabeth |e investigator |4 oth | |
700 | 1 | |a Adrião, Diana |e investigator |4 oth | |
700 | 1 | |a Al Ageel, Saleh |e investigator |4 oth | |
700 | 1 | |a Ahmed, Shakeel |e investigator |4 oth | |
700 | 1 | |a Ainscough, Kate |e investigator |4 oth | |
700 | 1 | |a Aisa, Tharwat |e investigator |4 oth | |
700 | 1 | |a Hssain, Ali Ait |e investigator |4 oth | |
700 | 1 | |a Tamlihat, Younes Ait |e investigator |4 oth | |
700 | 1 | |a Akimoto, Takako |e investigator |4 oth | |
700 | 1 | |a Akmal, Ernita |e investigator |4 oth | |
700 | 1 | |a Akwani, Chika |e investigator |4 oth | |
700 | 1 | |a Al Qasim, Eman |e investigator |4 oth | |
700 | 1 | |a Alalqam, Razi |e investigator |4 oth | |
700 | 1 | |a Alberti, Angela |e investigator |4 oth | |
700 | 1 | |a Al-Dabbous, Tala |e investigator |4 oth | |
700 | 1 | |a Alegesan, Senthilkumar |e investigator |4 oth | |
700 | 1 | |a Alessi, Marta |e investigator |4 oth | |
700 | 1 | |a Alex, Beatrice |e investigator |4 oth | |
700 | 1 | |a Alexandre, Kévin |e investigator |4 oth | |
700 | 1 | |a Al-Fares, Abdulrahman |e investigator |4 oth | |
700 | 1 | |a Alfoudri, Huda |e investigator |4 oth | |
700 | 1 | |a Ali, Imran |e investigator |4 oth | |
700 | 1 | |a Alidjnou, Kazali Enagnon |e investigator |4 oth | |
700 | 1 | |a Aliudin, Jeffrey |e investigator |4 oth | |
700 | 1 | |a Alkhafajee, Qabas |e investigator |4 oth | |
700 | 1 | |a Allavena, Clotilde |e investigator |4 oth | |
700 | 1 | |a Allou, Nathalie |e investigator |4 oth | |
700 | 1 | |a Alves, João |e investigator |4 oth | |
700 | 1 | |a Alves, Rita |e investigator |4 oth | |
700 | 1 | |a Alves, João Melo |e investigator |4 oth | |
700 | 1 | |a Cabrita, Joana Alves |e investigator |4 oth | |
700 | 1 | |a Amaral, Maria |e investigator |4 oth | |
700 | 1 | |a Amira, Nur |e investigator |4 oth | |
700 | 1 | |a Ampaw, Phoebe |e investigator |4 oth | |
700 | 1 | |a Andini, Roberto |e investigator |4 oth | |
700 | 1 | |a Andréjak, Claire |e investigator |4 oth | |
700 | 1 | |a Angheben, Andrea |e investigator |4 oth | |
700 | 1 | |a Angoulvant, François |e investigator |4 oth | |
700 | 1 | |a Ansart, Séverine |e investigator |4 oth | |
700 | 1 | |a Anthonidass, Sivanesen |e investigator |4 oth | |
700 | 1 | |a Antonelli, Massimo |e investigator |4 oth | |
700 | 1 | |a de Brito, Carlos Alexandre Antunes |e investigator |4 oth | |
700 | 1 | |a Apriyana, Ardiyan |e investigator |4 oth | |
700 | 1 | |a Arabi, Yaseen |e investigator |4 oth | |
700 | 1 | |a Aragao, Irene |e investigator |4 oth | |
700 | 1 | |a Arancibia, Francisco |e investigator |4 oth | |
700 | 1 | |a Araujo, Carolline |e investigator |4 oth | |
700 | 1 | |a Arcadipane, Antonio |e investigator |4 oth | |
700 | 1 | |a Archambault, Patrick |e investigator |4 oth | |
700 | 1 | |a Arenz, Lukas |e investigator |4 oth | |
700 | 1 | |a Arlet, Jean-Benoît |e investigator |4 oth | |
700 | 1 | |a Arnold-Day, Christel |e investigator |4 oth | |
700 | 1 | |a Arora, Lovkesh |e investigator |4 oth | |
700 | 1 | |a Arora, Rakesh |e investigator |4 oth | |
700 | 1 | |a Artaud-Macari, Elise |e investigator |4 oth | |
700 | 1 | |a Aryal, Diptesh |e investigator |4 oth | |
700 | 1 | |a Asensio, Angel |e investigator |4 oth | |
700 | 1 | |a Ashraf, Muhammad |e investigator |4 oth | |
700 | 1 | |a Assie, Jean Baptiste |e investigator |4 oth | |
700 | 1 | |a Asyraf, Amirul |e investigator |4 oth | |
700 | 1 | |a Atif, Minahel |e investigator |4 oth | |
700 | 1 | |a Atique, Anika |e investigator |4 oth | |
700 | 1 | |a Auchabie, Johann |e investigator |4 oth | |
700 | 1 | |a Aumaitre, Hugues |e investigator |4 oth | |
700 | 1 | |a Auvet, Adrien |e investigator |4 oth | |
700 | 1 | |a Azemar, Laurène |e investigator |4 oth | |
700 | 1 | |a Azoulay, Cecile |e investigator |4 oth | |
700 | 1 | |a Bach, Benjamin |e investigator |4 oth | |
700 | 1 | |a Bachelet, Delphine |e investigator |4 oth | |
700 | 1 | |a Badr, Claudine |e investigator |4 oth | |
700 | 1 | |a Baig, Nadia |e investigator |4 oth | |
700 | 1 | |a Baillie, J Kenneth |e investigator |4 oth | |
700 | 1 | |a Bak, Erica |e investigator |4 oth | |
700 | 1 | |a Bakakos, Agamemnon |e investigator |4 oth | |
700 | 1 | |a Bakar, Nazreen Abu |e investigator |4 oth | |
700 | 1 | |a Bal, Andriy |e investigator |4 oth | |
700 | 1 | |a Balakrishnan, Mohanaprasanth |e investigator |4 oth | |
700 | 1 | |a Balan, Valeria |e investigator |4 oth | |
700 | 1 | |a Bani-Sadr, Firouzé |e investigator |4 oth | |
700 | 1 | |a Barbalho, Renata |e investigator |4 oth | |
700 | 1 | |a Barbosa, Nicholas Yuri |e investigator |4 oth | |
700 | 1 | |a Barclay, Wendy S |e investigator |4 oth | |
700 | 1 | |a Barnett, Saef Umar |e investigator |4 oth | |
700 | 1 | |a Barnikel, Michaela |e investigator |4 oth | |
700 | 1 | |a Barrasa, Helena |e investigator |4 oth | |
700 | 1 | |a Barrelet, Audrey |e investigator |4 oth | |
700 | 1 | |a Barrigoto, Cleide |e investigator |4 oth | |
700 | 1 | |a Bartoli, Marie |e investigator |4 oth | |
700 | 1 | |a Baruch, Joaquín |e investigator |4 oth | |
700 | 1 | |a Basmaci, Romain |e investigator |4 oth | |
700 | 1 | |a Basri, Muhammad Fadhli Hassin |e investigator |4 oth | |
700 | 1 | |a Battaglini, Denise |e investigator |4 oth | |
700 | 1 | |a Bauer, Jules |e investigator |4 oth | |
773 | 0 | 8 | |i Enthalten in |t Research and practice in thrombosis and haemostasis |d 2017 |g 7(2023), 5 vom: 01. Juli, Seite 102142 |w (DE-627)NLM277257743 |x 2475-0379 |7 nnns |
773 | 1 | 8 | |g volume:7 |g year:2023 |g number:5 |g day:01 |g month:07 |g pages:102142 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.rpth.2023.102142 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 7 |j 2023 |e 5 |b 01 |c 07 |h 102142 |