Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits
© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ..
OBJECTIVES: This study aims to identify circulating proteins that are causally associated with osteoarthritis (OA)-related traits through Mendelian randomisation (MR)-based analytical framework.
METHODS: Large-scale two-sample MR was employed to estimate the effects of thousands of plasma proteins on 12 OA-related traits. Additional analyses including Bayesian colocalisation, Steiger filtering analysis, assessment of protein-altering variants and mapping expression quantitative trait loci to protein quantitative trait loci were performed to investigate the reliability of the MR findings; protein-protein interaction, pathway enrichment analysis and evaluation of drug targets were conducted to deepen the understanding and identify potential therapeutic targets of OA.
RESULTS: Dozens of circulating proteins were identified to have putatively causal effects on OA-related traits, and a majority of these proteins were either drug targets or considered druggable.
CONCLUSIONS: Through MR analysis, we have identified numerous plasma proteins associated with OA-related traits, shedding light on protein-mediated mechanisms and offering promising therapeutic targets for OA.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:82 |
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| Enthalten in: |
Annals of the rheumatic diseases - 82(2023), 12 vom: 18. Dez., Seite 1606-1617 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Yan [VerfasserIn] |
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| Links: |
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| Themen: |
Blood Proteins |
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| Anmerkungen: |
Date Completed 13.11.2023 Date Revised 19.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1136/ard-2023-224459 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360947743 |
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| 100 | 1 | |a Zhang, Yan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits |
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| 500 | |a Date Revised 19.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a OBJECTIVES: This study aims to identify circulating proteins that are causally associated with osteoarthritis (OA)-related traits through Mendelian randomisation (MR)-based analytical framework | ||
| 520 | |a METHODS: Large-scale two-sample MR was employed to estimate the effects of thousands of plasma proteins on 12 OA-related traits. Additional analyses including Bayesian colocalisation, Steiger filtering analysis, assessment of protein-altering variants and mapping expression quantitative trait loci to protein quantitative trait loci were performed to investigate the reliability of the MR findings; protein-protein interaction, pathway enrichment analysis and evaluation of drug targets were conducted to deepen the understanding and identify potential therapeutic targets of OA | ||
| 520 | |a RESULTS: Dozens of circulating proteins were identified to have putatively causal effects on OA-related traits, and a majority of these proteins were either drug targets or considered druggable | ||
| 520 | |a CONCLUSIONS: Through MR analysis, we have identified numerous plasma proteins associated with OA-related traits, shedding light on protein-mediated mechanisms and offering promising therapeutic targets for OA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Genetic | |
| 650 | 4 | |a Osteoarthritis | |
| 650 | 4 | |a Polymorphism | |
| 650 | 7 | |a Proteome |2 NLM | |
| 650 | 7 | |a Blood Proteins |2 NLM | |
| 700 | 1 | |a Xie, Jingyu |e verfasserin |4 aut | |
| 700 | 1 | |a Wen, Simin |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Peihua |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Wende |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Jianwei |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Shengfa |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhiqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Cen, Han |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Zhaohua |e verfasserin |4 aut | |
| 700 | 1 | |a Ding, Changhai |e verfasserin |4 aut | |
| 700 | 1 | |a Ruan, Guangfeng |e verfasserin |4 aut | |
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