Pathophysiology, diagnosis, and management of neuroinflammation in covid-19
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions..
Although neurological complications of SARS-CoV-2 infection are relatively rare, their potential long term morbidity and mortality have a significant impact, given the large numbers of infected patients. Covid-19 is now in the differential diagnosis of a number of common neurological syndromes including encephalopathy, encephalitis, acute demyelinating encephalomyelitis, stroke, and Guillain-Barré syndrome. Physicians should be aware of the pathophysiology underlying these presentations to diagnose and treat patients rapidly and appropriately. Although good evidence has been found for neurovirulence, the neuroinvasive and neurotropic potential of SARS-CoV-2 is limited. The pathophysiology of most complications is immune mediated and vascular, or both. A significant proportion of patients have developed long covid, which can include neuropsychiatric presentations. The mechanisms of long covid remain unclear. The longer term consequences of infection with covid-19 on the brain, particularly in terms of neurodegeneration, will only become apparent with time and long term follow-up.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:382 |
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| Enthalten in: |
BMJ (Clinical research ed.) - 382(2023) vom: 18. Aug., Seite e073923 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Brown, Rachel L [VerfasserIn] |
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Date Completed 21.08.2023 Date Revised 26.10.2023 published: Electronic ErratumIn: BMJ. 2023 Oct 26;383:p2451. - PMID 37884297 Citation Status MEDLINE |
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| doi: |
10.1136/bmj-2022-073923 |
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| 500 | |a ErratumIn: BMJ. 2023 Oct 26;383:p2451. - PMID 37884297 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. | ||
| 520 | |a Although neurological complications of SARS-CoV-2 infection are relatively rare, their potential long term morbidity and mortality have a significant impact, given the large numbers of infected patients. Covid-19 is now in the differential diagnosis of a number of common neurological syndromes including encephalopathy, encephalitis, acute demyelinating encephalomyelitis, stroke, and Guillain-Barré syndrome. Physicians should be aware of the pathophysiology underlying these presentations to diagnose and treat patients rapidly and appropriately. Although good evidence has been found for neurovirulence, the neuroinvasive and neurotropic potential of SARS-CoV-2 is limited. The pathophysiology of most complications is immune mediated and vascular, or both. A significant proportion of patients have developed long covid, which can include neuropsychiatric presentations. The mechanisms of long covid remain unclear. The longer term consequences of infection with covid-19 on the brain, particularly in terms of neurodegeneration, will only become apparent with time and long term follow-up | ||
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| 700 | 1 | |a Lunn, Michael P |e verfasserin |4 aut | |
| 700 | 1 | |a Bharucha, Tehmina |e verfasserin |4 aut | |
| 700 | 1 | |a Zandi, Michael S |e verfasserin |4 aut | |
| 700 | 1 | |a Hoskote, Chandrashekar |e verfasserin |4 aut | |
| 700 | 1 | |a McNamara, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Manji, Hadi |e verfasserin |4 aut | |
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