The PURPOSe cause of death study in stillbirths and neonatal deaths in India and Pakistan : A review
© 2023 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd..
The PURPOSe study was a prospective, observational study conducted in India and Pakistan to determine the cause of death for stillbirths and preterm neonatal deaths, using clinical data together with minimally invasive tissue sampling (MITS) and the histologic and polymerase chain reaction (PCR) evaluation of fetal/neonatal tissues and the placenta. After evaluating all available data, an independent panel chose a maternal, a placental and a fetal/neonatal cause of death. Here, we summarise the major results. Among the most important findings were that most stillbirths were caused by fetal asphyxia, often preceded by placental malperfusion, and clinically associated with pre-eclampsia, placental abruption and a small-for-gestational-age fetus. The preterm neonatal deaths were primarily caused by birth asphyxia, followed by various infections. An important finding was that many of the preterm neonatal deaths were caused by a nosocomial infection acquired after neonatal intensive care (NICU) admission; the most common organisms were Acinetobacter baumannii, followed by Klebsiella pneumoniae, Escherichia coli/Shigella and Haemophilus influenzae. Group B streptococcus was less commonly present in the placentas or internal organs of the neonatal deaths.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:130 Suppl 3 |
|---|---|
| Enthalten in: |
BJOG : an international journal of obstetrics and gynaecology - 130 Suppl 3(2023) vom: 18. Nov., Seite 26-35 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Goldenberg, Robert L [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cause of death |
|---|
| Anmerkungen: |
Date Completed 13.11.2023 Date Revised 13.11.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1111/1471-0528.17635 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM360916015 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM360916015 | ||
| 003 | DE-627 | ||
| 005 | 20231226084031.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/1471-0528.17635 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1202.xml |
| 035 | |a (DE-627)NLM360916015 | ||
| 035 | |a (NLM)37592743 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Goldenberg, Robert L |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The PURPOSe cause of death study in stillbirths and neonatal deaths in India and Pakistan |b A review |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 13.11.2023 | ||
| 500 | |a Date Revised 13.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. | ||
| 520 | |a The PURPOSe study was a prospective, observational study conducted in India and Pakistan to determine the cause of death for stillbirths and preterm neonatal deaths, using clinical data together with minimally invasive tissue sampling (MITS) and the histologic and polymerase chain reaction (PCR) evaluation of fetal/neonatal tissues and the placenta. After evaluating all available data, an independent panel chose a maternal, a placental and a fetal/neonatal cause of death. Here, we summarise the major results. Among the most important findings were that most stillbirths were caused by fetal asphyxia, often preceded by placental malperfusion, and clinically associated with pre-eclampsia, placental abruption and a small-for-gestational-age fetus. The preterm neonatal deaths were primarily caused by birth asphyxia, followed by various infections. An important finding was that many of the preterm neonatal deaths were caused by a nosocomial infection acquired after neonatal intensive care (NICU) admission; the most common organisms were Acinetobacter baumannii, followed by Klebsiella pneumoniae, Escherichia coli/Shigella and Haemophilus influenzae. Group B streptococcus was less commonly present in the placentas or internal organs of the neonatal deaths | ||
| 650 | 4 | |a Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a India | |
| 650 | 4 | |a PURPOSe study | |
| 650 | 4 | |a Pakistan | |
| 650 | 4 | |a cause of death | |
| 650 | 4 | |a preterm neonatal death | |
| 650 | 4 | |a stillbirth | |
| 700 | 1 | |a Saleem, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Goudar, Shivaprasad S |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, Janet |e verfasserin |4 aut | |
| 700 | 1 | |a Guruprasad, Gowdar |e verfasserin |4 aut | |
| 700 | 1 | |a Kulkarni, Vardendra |e verfasserin |4 aut | |
| 700 | 1 | |a Dhaded, Sangappa M |e verfasserin |4 aut | |
| 700 | 1 | |a Tikmani, Shiyam Sunder |e verfasserin |4 aut | |
| 700 | 1 | |a Nausheen, Sidrah |e verfasserin |4 aut | |
| 700 | 1 | |a Masheer, Shazia |e verfasserin |4 aut | |
| 700 | 1 | |a Kallapur, Mangala G |e verfasserin |4 aut | |
| 700 | 1 | |a Ghanchi, Najia K |e verfasserin |4 aut | |
| 700 | 1 | |a Harakuni, Sheetal U |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmed, Imran |e verfasserin |4 aut | |
| 700 | 1 | |a Hwang, Kay |e verfasserin |4 aut | |
| 700 | 1 | |a Yogeshkumar, S |e verfasserin |4 aut | |
| 700 | 1 | |a Somannavar, Manjunath S |e verfasserin |4 aut | |
| 700 | 1 | |a Yasmin, Haleema |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Jean |e verfasserin |4 aut | |
| 700 | 1 | |a Bann, Carla M |e verfasserin |4 aut | |
| 700 | 1 | |a Silver, Robert M |e verfasserin |4 aut | |
| 700 | 1 | |a McClure, Elizabeth M |e verfasserin |4 aut | |
| 700 | 0 | |a PURPOSe Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Nagmoti, Mahantesh B |e investigator |4 oth | |
| 700 | 1 | |a Aradhya, Gayathri H |e investigator |4 oth | |
| 700 | 1 | |a Nadig, Naveen |e investigator |4 oth | |
| 700 | 1 | |a Kusgur, Varun |e investigator |4 oth | |
| 700 | 1 | |a Raghoji, Chaitali R |e investigator |4 oth | |
| 700 | 1 | |a Sarvamangala, B |e investigator |4 oth | |
| 700 | 1 | |a Prakash, Veena |e investigator |4 oth | |
| 700 | 1 | |a Joish, Upendra Kumar |e investigator |4 oth | |
| 700 | 1 | |a Mangala, G K |e investigator |4 oth | |
| 700 | 1 | |a Rajashekhar, K S |e investigator |4 oth | |
| 700 | 1 | |a Sunilkumar, K Byranahalli |e investigator |4 oth | |
| 700 | 1 | |a Siddartha, E S |e investigator |4 oth | |
| 700 | 1 | |a Patil, Lingaraja Gowda C |e investigator |4 oth | |
| 700 | 1 | |a Pujar, Sneharoopa |e investigator |4 oth | |
| 700 | 1 | |a Dhananjaya, Shobha |e investigator |4 oth | |
| 700 | 1 | |a Nagaraj, T S |e investigator |4 oth | |
| 700 | 1 | |a Jeevika, M U |e investigator |4 oth | |
| 700 | 1 | |a Harikiran, Reddy R |e investigator |4 oth | |
| 700 | 1 | |a Zafar, Afia |e investigator |4 oth | |
| 700 | 1 | |a Uddin, Zeeshan |e investigator |4 oth | |
| 700 | 1 | |a Ghanchi, Najia |e investigator |4 oth | |
| 700 | 1 | |a Roujani, Sana |e investigator |4 oth | |
| 700 | 1 | |a Ariff, Shabina |e investigator |4 oth | |
| 700 | 1 | |a Sheikh, Lumaan |e investigator |4 oth | |
| 700 | 1 | |a Mirza, Waseem |e investigator |4 oth | |
| 700 | 1 | |a Raza, Jamal |e investigator |4 oth | |
| 700 | 1 | |a Prakash, Jai |e investigator |4 oth | |
| 700 | 1 | |a Haider, Furqan |e investigator |4 oth | |
| 700 | 1 | |a Aceituno, Anna |e investigator |4 oth | |
| 700 | 1 | |a Parlberg, Lindsay |e investigator |4 oth | |
| 700 | 1 | |a LMoore, Janet |e investigator |4 oth | |
| 700 | 1 | |a Parepelli, Suchita |e investigator |4 oth | |
| 700 | 1 | |a Bann, Carla |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t BJOG : an international journal of obstetrics and gynaecology |d 2000 |g 130 Suppl 3(2023) vom: 18. Nov., Seite 26-35 |w (DE-627)NLM10574820X |x 1471-0528 |7 nnns |
| 773 | 1 | 8 | |g volume:130 Suppl 3 |g year:2023 |g day:18 |g month:11 |g pages:26-35 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/1471-0528.17635 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 130 Suppl 3 |j 2023 |b 18 |c 11 |h 26-35 | ||