Immune-mediated cerebellitis following SARS-CoV-2 infection-a case report and review of the literature
© 2023. The Author(s) under exclusive licence to The Journal of NeuroVirology, Inc..
The coronavirus disease 2019 (COVID-19) can be associated with a wide variety of neurological manifestations. Some of these manifestations might result from the ongoing systemic inflammatory state, but the pathophysiology of specific neurologic involvement is still unclear. In this article, we report a patient who developed an isolated cerebellar syndrome 9 weeks after an episode of COVID-19. The reverse-transcriptase polymerase chain reaction (RT-PCR) for SARS-CoV-2 was positive on cerebrospinal fluid (CSF). A post-infectious-autoimmune-cerebellitis following COVID-19 was suspected, and the patient was treated with corticosteroids, leading to a complete recovery within a few weeks. We review the other cases of COVID-19-associated cerebellar syndrome reported so far and discuss the potential pathophysiological mechanisms underlying this neurologic manifestation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Journal of neurovirology - 29(2023), 4 vom: 17. Aug., Seite 507-518 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Plumacker, Florence [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 15.09.2023 Date Revised 25.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s13365-023-01163-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360890628 |
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| 520 | |a © 2023. The Author(s) under exclusive licence to The Journal of NeuroVirology, Inc. | ||
| 520 | |a The coronavirus disease 2019 (COVID-19) can be associated with a wide variety of neurological manifestations. Some of these manifestations might result from the ongoing systemic inflammatory state, but the pathophysiology of specific neurologic involvement is still unclear. In this article, we report a patient who developed an isolated cerebellar syndrome 9 weeks after an episode of COVID-19. The reverse-transcriptase polymerase chain reaction (RT-PCR) for SARS-CoV-2 was positive on cerebrospinal fluid (CSF). A post-infectious-autoimmune-cerebellitis following COVID-19 was suspected, and the patient was treated with corticosteroids, leading to a complete recovery within a few weeks. We review the other cases of COVID-19-associated cerebellar syndrome reported so far and discuss the potential pathophysiological mechanisms underlying this neurologic manifestation | ||
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