Paraneoplastic Cerebellar Degeneration Accompanied by Seropositivity for Anti-GAD65, Anti-SOX-1 and Anti-VGCC Antibodies Due to Small-cell Lung Cancer
Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic neurological syndrome that is rarely accompanied by seropositivity with a combination of multiple antibodies. We herein report a 50-year-old man with PCD accompanied by small-cell lung cancer (SCLC). This patient was seropositive for anti-glutamic acid decarboxylase 65, anti-SRY-related HMG-box gene 1 and anti-voltage-gated calcium channel antibodies. After chemoradiation therapy without immunotherapy, cerebellar ataxia of the trunk and limbs markedly improved, along with a notable amelioration of SCLC. This case suggests that tumor therapy should be started immediately and that a panel of anti-neuronal antibodies should be evaluated when PCD with SCLC is suspected.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:63 |
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| Enthalten in: |
Internal medicine (Tokyo, Japan) - 63(2024), 6 vom: 15. März, Seite 857-860 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Takahashi, Naomi [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-GAD65 antibody |
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| Anmerkungen: |
Date Completed 19.03.2024 Date Revised 13.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2169/internalmedicine.0738-22 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360862349 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Paraneoplastic cerebellar degeneration (PCD) is a paraneoplastic neurological syndrome that is rarely accompanied by seropositivity with a combination of multiple antibodies. We herein report a 50-year-old man with PCD accompanied by small-cell lung cancer (SCLC). This patient was seropositive for anti-glutamic acid decarboxylase 65, anti-SRY-related HMG-box gene 1 and anti-voltage-gated calcium channel antibodies. After chemoradiation therapy without immunotherapy, cerebellar ataxia of the trunk and limbs markedly improved, along with a notable amelioration of SCLC. This case suggests that tumor therapy should be started immediately and that a panel of anti-neuronal antibodies should be evaluated when PCD with SCLC is suspected | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a anti-GAD65 antibody | |
| 650 | 4 | |a anti-SOX-1 antibody | |
| 650 | 4 | |a anti-VGCC antibody | |
| 650 | 4 | |a paraneoplastic cerebellar degeneration | |
| 650 | 4 | |a small-cell lung cancer | |
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| 650 | 7 | |a Autoantibodies |2 NLM | |
| 700 | 1 | |a Igari, Ryosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Iseki, Chifumi |e verfasserin |4 aut | |
| 700 | 1 | |a Kawahara, Hikaru |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Daisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Yuya |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Hiroyasu |e verfasserin |4 aut | |
| 700 | 1 | |a Koyama, Shingo |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, Maki |e verfasserin |4 aut | |
| 700 | 1 | |a Ohta, Yasuyuki |e verfasserin |4 aut | |
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