Racial Disparities in Liver Transplantation for Hepatocellular Carcinoma in the United States : An Update
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply..
BACKGROUND: Previous studies have demonstrated a disparity in liver transplantation (LT) for hepatocellular carcinoma (HCC) among races in the United States (U.S.).
AIMS: We aimed to update the literature on the odds, trends, and complications of LT in the treatment of hepatocellular carcinoma (HCC), among individuals of different racial backgrounds.
METHODS: This is a nationwide study of adult individuals admitted for LT with a primary diagnosis of HCC. Using weighted data from the National Inpatient Sample (NIS) database, we compared the odds of LT among different races from 2016 to 2020, using a multivariate regression analysis. We further assessed the trends and outcomes of LT among races.
RESULTS: A total of 112,110 adult were hospitalized with a primary diagnosis of HCC. 3020 underwent LT. When compared to Whites, the likelihood of undergoing LT for HCC was significantly reduced in Blacks (OR = 0.60, 95% CI = 0.46-0.78). Further, Blacks had increased mortality rates (7% in Blacks vs. 1% in Whites, p < 0.001), sepsis (11% in Blacks vs. 3% in Whites, p = 0.015), and acute kidney injury (AKI) (54% in Blacks vs. 31% in Whites, p < 0.001) following LT.
CONCLUSIONS: Individuals identifying as Blacks were less likely to undergo LT for HCC, and more likely to develop complications. Further initiatives are warranted to mitigate the existing disparities among racial groups.
| Errataetall: |
ErratumIn: Dig Dis Sci. 2023 Dec;68(12):4538-4539. - PMID 37831400 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:68 |
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| Enthalten in: |
Digestive diseases and sciences - 68(2023), 10 vom: 16. Okt., Seite 4050-4059 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kilani, Yassine [VerfasserIn] |
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| Links: |
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| Themen: |
Hepatocellular carcinoma |
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| Anmerkungen: |
Date Completed 25.09.2023 Date Revised 13.10.2023 published: Print-Electronic ErratumIn: Dig Dis Sci. 2023 Dec;68(12):4538-4539. - PMID 37831400 Citation Status MEDLINE |
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| doi: |
10.1007/s10620-023-08084-z |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a ErratumIn: Dig Dis Sci. 2023 Dec;68(12):4538-4539. - PMID 37831400 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. | ||
| 520 | |a BACKGROUND: Previous studies have demonstrated a disparity in liver transplantation (LT) for hepatocellular carcinoma (HCC) among races in the United States (U.S.) | ||
| 520 | |a AIMS: We aimed to update the literature on the odds, trends, and complications of LT in the treatment of hepatocellular carcinoma (HCC), among individuals of different racial backgrounds | ||
| 520 | |a METHODS: This is a nationwide study of adult individuals admitted for LT with a primary diagnosis of HCC. Using weighted data from the National Inpatient Sample (NIS) database, we compared the odds of LT among different races from 2016 to 2020, using a multivariate regression analysis. We further assessed the trends and outcomes of LT among races | ||
| 520 | |a RESULTS: A total of 112,110 adult were hospitalized with a primary diagnosis of HCC. 3020 underwent LT. When compared to Whites, the likelihood of undergoing LT for HCC was significantly reduced in Blacks (OR = 0.60, 95% CI = 0.46-0.78). Further, Blacks had increased mortality rates (7% in Blacks vs. 1% in Whites, p < 0.001), sepsis (11% in Blacks vs. 3% in Whites, p = 0.015), and acute kidney injury (AKI) (54% in Blacks vs. 31% in Whites, p < 0.001) following LT | ||
| 520 | |a CONCLUSIONS: Individuals identifying as Blacks were less likely to undergo LT for HCC, and more likely to develop complications. Further initiatives are warranted to mitigate the existing disparities among racial groups | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Hepatocellular carcinoma | |
| 650 | 4 | |a Liver transplant | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Outcomes | |
| 650 | 4 | |a Racial disparities | |
| 700 | 1 | |a Kamal, Syeda Ashna Fatima |e verfasserin |4 aut | |
| 700 | 1 | |a Vikash, Fnu |e verfasserin |4 aut | |
| 700 | 1 | |a Vikash, Sindhu |e verfasserin |4 aut | |
| 700 | 1 | |a Aldiabat, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Alsakarneh, Saqr |e verfasserin |4 aut | |
| 700 | 1 | |a Aljabiri, Yazan |e verfasserin |4 aut | |
| 700 | 1 | |a Sohail, Haris |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, Vikash |e verfasserin |4 aut | |
| 700 | 1 | |a Numan, Laith |e verfasserin |4 aut | |
| 700 | 1 | |a Al Khalloufi, Kawtar |e verfasserin |4 aut | |
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