In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells
Background: More studies using cobalt complexes as drugs are needed. Results: The drug action of two cobalt salicylaldimines was determined. The complexes and amphotericin B (20 mg/ml) inhibited Candida albicans at 9-15 and 21 mm. This concentration of both ligands inhibited Staphylococcus aureus at 10 mm and one ligand inhibited Escherichia coli at 9 mm, but the complexes and ampicillin inhibited four bacteria at 9-20 and 21-26 mm. The ligands were inactive against cancer and normal cells, but the complexes and doxorubicin provided IC50 values of 28.18-54.19 and 9.66 μM against MCF-7 cells and 15.76-20.49 and 36.42 μM against BHK cells. Conclusion: The ligands' activity was much improved by complexation, although they remained substandard.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Future medicinal chemistry - 15(2023), 15 vom: 16. Aug., Seite 1415-1426 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Williem, Ereny S [VerfasserIn] |
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| Links: |
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| Themen: |
Anionic ligands |
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| Anmerkungen: |
Date Revised 10.10.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.4155/fmc-2023-0190 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360834949 |
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| 245 | 1 | 0 | |a In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells |
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| 520 | |a Background: More studies using cobalt complexes as drugs are needed. Results: The drug action of two cobalt salicylaldimines was determined. The complexes and amphotericin B (20 mg/ml) inhibited Candida albicans at 9-15 and 21 mm. This concentration of both ligands inhibited Staphylococcus aureus at 10 mm and one ligand inhibited Escherichia coli at 9 mm, but the complexes and ampicillin inhibited four bacteria at 9-20 and 21-26 mm. The ligands were inactive against cancer and normal cells, but the complexes and doxorubicin provided IC50 values of 28.18-54.19 and 9.66 μM against MCF-7 cells and 15.76-20.49 and 36.42 μM against BHK cells. Conclusion: The ligands' activity was much improved by complexation, although they remained substandard | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Marek, Jaromír |e verfasserin |4 aut | |
| 700 | 1 | |a Abbas, S M |e verfasserin |4 aut | |
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