Associations between ambient temperature and pregnancy outcomes from three south Asian sites of the Global Network Maternal Newborn Health Registry : A retrospective cohort study
© 2023 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd..
OBJECTIVE: Growing evidence suggests that environmental heat stress negatively influences fetal growth and pregnancy outcomes. However, few studies have examined the impact of heat stress on pregnancy outcomes in low-resource settings. We combined data from a large multi-country maternal-child health registry and meteorological data to assess the impacts of heat stress.
DESIGN: Retrospective cohort study.
SETTING: Three sites based in south Asia as part of the Global Network for Women's and Children's Health research in India (Belagavi and Nagpur) and Pakistan (Thatta).
POPULATION OR SAMPLE: Data from women enrolled between 2014 and 2020 in the Global Network's Maternal Newborn Health Registry (MNHR), a prospective, population-based registry of pregnancies, were used.
METHODS: A total of 126 273 pregnant women were included in this analysis. Daily maximal air temperatures (Tmax ) were acquired from local meteorological records. Associations between averages of daily maximal temperatures for each trimester and main outcomes were analysed using a modified Poisson regression approach.
MAIN OUTCOMES MEASURES: Incidence of stillbirth, preterm birth, low birthweight (<2500 g) or evidence of pregnancy hypertension or pre-eclampsia.
RESULTS: In the overall cohort, risk of preterm birth was positively associated with greater temperature in the second trimester (relative risk [RR] 1.05, 95% CI 1.02-1.07, p = 0.0002). Among individual sites, the risk of preterm birth was greatest in Nagpur (RR 1.07, 95% CI 1.03-1.11, p = 0.0005) and associated with second-trimester temperature. The overall risk of low birthweight was associated with ambient temperature in second trimester (RR 1.02, 95% CI 1.01-1.04, p = 0.01). The risk for LBW was associated with first-trimester heat in Thatta and with second-trimester heat in Nagpur. Finally, the overall risk of gestational hypertensive disease was associated with greater temperature in the third trimester among all sites (RR 1.07, 95% CI 1.02-1.12, p = 0.005) and was particularly significant for Nagpur (RR 1.13, 95% CI 1.05-1.23, p = 0.002). These findings highlight the increased risk of detrimental obstetric and neonatal outcomes with greater temperature.
CONCLUSION: In a multi-country, community-based study, greater risk of adverse outcomes was observed with increasing temperature. The study highlights the need for deeper understanding of covarying factors and intervention strategies, especially in regions where high temperatures are common.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:130 Suppl 3 |
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| Enthalten in: |
BJOG : an international journal of obstetrics and gynaecology - 130 Suppl 3(2023) vom: 07. Nov., Seite 124-133 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shankar, Kartik [VerfasserIn] |
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| Links: |
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| Themen: |
Climate change |
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| Anmerkungen: |
Date Completed 13.11.2023 Date Revised 07.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/1471-0528.17616 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Shankar, Kartik |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Associations between ambient temperature and pregnancy outcomes from three south Asian sites of the Global Network Maternal Newborn Health Registry |b A retrospective cohort study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 13.11.2023 | ||
| 500 | |a Date Revised 07.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. | ||
| 520 | |a OBJECTIVE: Growing evidence suggests that environmental heat stress negatively influences fetal growth and pregnancy outcomes. However, few studies have examined the impact of heat stress on pregnancy outcomes in low-resource settings. We combined data from a large multi-country maternal-child health registry and meteorological data to assess the impacts of heat stress | ||
| 520 | |a DESIGN: Retrospective cohort study | ||
| 520 | |a SETTING: Three sites based in south Asia as part of the Global Network for Women's and Children's Health research in India (Belagavi and Nagpur) and Pakistan (Thatta) | ||
| 520 | |a POPULATION OR SAMPLE: Data from women enrolled between 2014 and 2020 in the Global Network's Maternal Newborn Health Registry (MNHR), a prospective, population-based registry of pregnancies, were used | ||
| 520 | |a METHODS: A total of 126 273 pregnant women were included in this analysis. Daily maximal air temperatures (Tmax ) were acquired from local meteorological records. Associations between averages of daily maximal temperatures for each trimester and main outcomes were analysed using a modified Poisson regression approach | ||
| 520 | |a MAIN OUTCOMES MEASURES: Incidence of stillbirth, preterm birth, low birthweight (<2500 g) or evidence of pregnancy hypertension or pre-eclampsia | ||
| 520 | |a RESULTS: In the overall cohort, risk of preterm birth was positively associated with greater temperature in the second trimester (relative risk [RR] 1.05, 95% CI 1.02-1.07, p = 0.0002). Among individual sites, the risk of preterm birth was greatest in Nagpur (RR 1.07, 95% CI 1.03-1.11, p = 0.0005) and associated with second-trimester temperature. The overall risk of low birthweight was associated with ambient temperature in second trimester (RR 1.02, 95% CI 1.01-1.04, p = 0.01). The risk for LBW was associated with first-trimester heat in Thatta and with second-trimester heat in Nagpur. Finally, the overall risk of gestational hypertensive disease was associated with greater temperature in the third trimester among all sites (RR 1.07, 95% CI 1.02-1.12, p = 0.005) and was particularly significant for Nagpur (RR 1.13, 95% CI 1.05-1.23, p = 0.002). These findings highlight the increased risk of detrimental obstetric and neonatal outcomes with greater temperature | ||
| 520 | |a CONCLUSION: In a multi-country, community-based study, greater risk of adverse outcomes was observed with increasing temperature. The study highlights the need for deeper understanding of covarying factors and intervention strategies, especially in regions where high temperatures are common | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a climate change | |
| 650 | 4 | |a heat stress | |
| 650 | 4 | |a low birthweight | |
| 650 | 4 | |a pre-eclampsia | |
| 650 | 4 | |a pregnancy | |
| 650 | 4 | |a stillbirth | |
| 700 | 1 | |a Hwang, Kay |e verfasserin |4 aut | |
| 700 | 1 | |a Westcott, Jamie L |e verfasserin |4 aut | |
| 700 | 1 | |a Saleem, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Ali, Sumera A |e verfasserin |4 aut | |
| 700 | 1 | |a Jessani, Saleem |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Archana |e verfasserin |4 aut | |
| 700 | 1 | |a Kavi, Avinash |e verfasserin |4 aut | |
| 700 | 1 | |a Somannavar, Manjunath S |e verfasserin |4 aut | |
| 700 | 1 | |a Goudar, Shivaprasad S |e verfasserin |4 aut | |
| 700 | 1 | |a Hibberd, Patricia L |e verfasserin |4 aut | |
| 700 | 1 | |a Derman, Richard J |e verfasserin |4 aut | |
| 700 | 1 | |a Hoffman, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Wylie, Blair J |e verfasserin |4 aut | |
| 700 | 1 | |a Goldenberg, Robert L |e verfasserin |4 aut | |
| 700 | 1 | |a Thorsten, Vanessa R |e verfasserin |4 aut | |
| 700 | 1 | |a McClure, Elizabeth M |e verfasserin |4 aut | |
| 700 | 1 | |a Krebs, Nancy F |e verfasserin |4 aut | |
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