Clinical availability and characteristics of multigene panel testing for recurrent/advanced gynecologic cancer
© 2023. The Author(s) under exclusive licence to Japan Society of Clinical Oncology..
BACKGROUND: Japan's health insurance covers multigene panel testing. This study aimed to determine the potential availability and utility of gene panel testing clinically in gynecologic oncology.
METHODS: We analyzed the characteristics of patients with gynecologic cancer who underwent gene panel testing using FoundationOne® CDx or OncoGuide™ NCC Oncopanel between November 2019 and October 2022.
RESULTS: Out of 102 patients analyzed, 32, 18, 43, 8, and 1 had cervical, endometrial, ovarian cancers, sarcoma, and vaginal cancer, respectively. Druggable gene alteration was found in 70 patients (68.6%; 21 with cervical cancer, 15 with endometrial cancer, 28 with ovarian cancer, 5 with sarcoma, and 1 with other). The most common druggable gene alteration was PIK3CA mutation (n = 21), followed by PTEN mutation (n = 12) and high tumor mutation burden (TMB-H) (n = 11). TMB-H was detected in 5 patients with cervical cancer, 5 with endometrial cancer, and 1 with endometrial stromal sarcoma. Eleven patients (10.8%) received molecularly targeted therapy according to their gene aberrations. Gene panel testing was mostly performed when the second-line treatment was ineffective. Of all 102 patients, 60 did not have recommended treatment, and 15 died or had worsened conditions before obtaining the test results.
CONCLUSION: Through multigene panel testing, although many patients had druggable gene alterations, 10.8% of them received the recommended treatment. TMB-H was mainly observed in cervical/endometrial cancer, suggesting its potential as a therapeutic biomarker of immune checkpoint inhibitors. Furthermore, patients' prognosis and performance status should be considered before performing the test.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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Enthalten in: |
International journal of clinical oncology - 28(2023), 11 vom: 14. Nov., Seite 1554-1562 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Kitazawa, Shoko [VerfasserIn] |
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Links: |
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Themen: |
Biomarkers, Tumor |
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Anmerkungen: |
Date Completed 02.11.2023 Date Revised 02.11.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1007/s10147-023-02398-8 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM360739849 |
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520 | |a BACKGROUND: Japan's health insurance covers multigene panel testing. This study aimed to determine the potential availability and utility of gene panel testing clinically in gynecologic oncology | ||
520 | |a METHODS: We analyzed the characteristics of patients with gynecologic cancer who underwent gene panel testing using FoundationOne® CDx or OncoGuide™ NCC Oncopanel between November 2019 and October 2022 | ||
520 | |a RESULTS: Out of 102 patients analyzed, 32, 18, 43, 8, and 1 had cervical, endometrial, ovarian cancers, sarcoma, and vaginal cancer, respectively. Druggable gene alteration was found in 70 patients (68.6%; 21 with cervical cancer, 15 with endometrial cancer, 28 with ovarian cancer, 5 with sarcoma, and 1 with other). The most common druggable gene alteration was PIK3CA mutation (n = 21), followed by PTEN mutation (n = 12) and high tumor mutation burden (TMB-H) (n = 11). TMB-H was detected in 5 patients with cervical cancer, 5 with endometrial cancer, and 1 with endometrial stromal sarcoma. Eleven patients (10.8%) received molecularly targeted therapy according to their gene aberrations. Gene panel testing was mostly performed when the second-line treatment was ineffective. Of all 102 patients, 60 did not have recommended treatment, and 15 died or had worsened conditions before obtaining the test results | ||
520 | |a CONCLUSION: Through multigene panel testing, although many patients had druggable gene alterations, 10.8% of them received the recommended treatment. TMB-H was mainly observed in cervical/endometrial cancer, suggesting its potential as a therapeutic biomarker of immune checkpoint inhibitors. Furthermore, patients' prognosis and performance status should be considered before performing the test | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Cancer genomic profiling | |
650 | 4 | |a Cervical cancer | |
650 | 4 | |a Endometrial cancer | |
650 | 4 | |a Molecular tumor board | |
650 | 4 | |a Ovarian cancer | |
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700 | 1 | |a Sakai, Kensuke |e verfasserin |4 aut | |
700 | 1 | |a Yoshihama, Tomoko |e verfasserin |4 aut | |
700 | 1 | |a Nishio, Hiroshi |e verfasserin |4 aut | |
700 | 1 | |a Kobayashi, Yusuke |e verfasserin |4 aut | |
700 | 1 | |a Iwata, Takashi |e verfasserin |4 aut | |
700 | 1 | |a Banno, Kouji |e verfasserin |4 aut | |
700 | 1 | |a Yamagami, Wataru |e verfasserin |4 aut | |
700 | 1 | |a Nishihara, Hiroshi |e verfasserin |4 aut | |
700 | 1 | |a Aoki, Daisuke |e verfasserin |4 aut | |
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