Ethnic and sex-related differences at presentation in apical hypertrophic cardiomyopathy : An observational cross-sectional study
Copyright © 2023. Published by Elsevier B.V..
BACKGROUND: We investigated whether ethnicity and sex are associated with different clinical presentations and cardiovascular magnetic resonance (CMR) findings in individuals with apical hypertrophic cardiomyopathy (ApHCM).
METHODS: A retrospective observational cohort study of consecutive ApHCM patients from a large tertiary referral center in the United Kingdom (UK). Demographic, clinical, 12‑lead electrocardiogram (ECG) and CMR findings were collected. Participants presented in our clinics between 2010 and 2020. 'Pure' ApHCM was defined as isolated apical hypertrophy and 'mixed' with both apical and septal hypertrophy but with the apical segments of a greater wall thickness. Deep T-wave inversion was defined as ≥5 mm in any electrocardiogram lead.
RESULTS: A total of 150 consecutive ApHCM patients (75% men, 25% women; 37% White, 25% Black, 24% Asian and 15% of Mixed/Other ethnicity) were included. Females were diagnosed at an older age compared to men, had less prominent ECG changes, had higher left atrial area index, and were more hypertensive. Black patients had higher left ventricular mass index, more hypertension, and more of the 'mixed' type of ApHCM. The majority of hypertensive male patients showed the 'mixed' phenotype.
CONCLUSIONS: Individuals of Black ethnicity and hypertensive male patients are more likely to present with mixed apical and basal hypertrophy, whereas White, Asian and non-hypertensive male patients tend to have hypertrophy limited to the apex. Females present at an older age and are less likely to have deep T wave inversion on ECG.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:391 |
|---|---|
| Enthalten in: |
International journal of cardiology - 391(2023) vom: 15. Nov., Seite 131265 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Khoury, Shafik [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Apical hypertrophy |
|---|
| Anmerkungen: |
Date Completed 02.10.2023 Date Revised 08.11.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.ijcard.2023.131265 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM360735118 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM360735118 | ||
| 003 | DE-627 | ||
| 005 | 20231226083638.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijcard.2023.131265 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1202.xml |
| 035 | |a (DE-627)NLM360735118 | ||
| 035 | |a (NLM)37574022 | ||
| 035 | |a (PII)S0167-5273(23)01143-9 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Khoury, Shafik |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ethnic and sex-related differences at presentation in apical hypertrophic cardiomyopathy |b An observational cross-sectional study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 02.10.2023 | ||
| 500 | |a Date Revised 08.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023. Published by Elsevier B.V. | ||
| 520 | |a BACKGROUND: We investigated whether ethnicity and sex are associated with different clinical presentations and cardiovascular magnetic resonance (CMR) findings in individuals with apical hypertrophic cardiomyopathy (ApHCM) | ||
| 520 | |a METHODS: A retrospective observational cohort study of consecutive ApHCM patients from a large tertiary referral center in the United Kingdom (UK). Demographic, clinical, 12‑lead electrocardiogram (ECG) and CMR findings were collected. Participants presented in our clinics between 2010 and 2020. 'Pure' ApHCM was defined as isolated apical hypertrophy and 'mixed' with both apical and septal hypertrophy but with the apical segments of a greater wall thickness. Deep T-wave inversion was defined as ≥5 mm in any electrocardiogram lead | ||
| 520 | |a RESULTS: A total of 150 consecutive ApHCM patients (75% men, 25% women; 37% White, 25% Black, 24% Asian and 15% of Mixed/Other ethnicity) were included. Females were diagnosed at an older age compared to men, had less prominent ECG changes, had higher left atrial area index, and were more hypertensive. Black patients had higher left ventricular mass index, more hypertension, and more of the 'mixed' type of ApHCM. The majority of hypertensive male patients showed the 'mixed' phenotype | ||
| 520 | |a CONCLUSIONS: Individuals of Black ethnicity and hypertensive male patients are more likely to present with mixed apical and basal hypertrophy, whereas White, Asian and non-hypertensive male patients tend to have hypertrophy limited to the apex. Females present at an older age and are less likely to have deep T wave inversion on ECG | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Apical hypertrophy | |
| 650 | 4 | |a Hypertension | |
| 650 | 4 | |a Hypertrophic cardiomyopathy | |
| 650 | 4 | |a Magnetic resonance imaging | |
| 700 | 1 | |a Bhatia, Raghav T |e verfasserin |4 aut | |
| 700 | 1 | |a Marwaha, Sarandeep |e verfasserin |4 aut | |
| 700 | 1 | |a Miles, Chris |e verfasserin |4 aut | |
| 700 | 1 | |a Kasiakogias, Alexandros |e verfasserin |4 aut | |
| 700 | 1 | |a Bunce, Nick |e verfasserin |4 aut | |
| 700 | 1 | |a Behr, Elijah |e verfasserin |4 aut | |
| 700 | 1 | |a Papadakis, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Sharma, Sanjay |e verfasserin |4 aut | |
| 700 | 1 | |a Tome, Maite |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cardiology |d 1984 |g 391(2023) vom: 15. Nov., Seite 131265 |w (DE-627)NLM012621196 |x 1874-1754 |7 nnns |
| 773 | 1 | 8 | |g volume:391 |g year:2023 |g day:15 |g month:11 |g pages:131265 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ijcard.2023.131265 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 391 |j 2023 |b 15 |c 11 |h 131265 | ||