Heterotopic intestine and abdominal wall transplantation in a miniature swine : A model for graft immunology
© 2023 The Authors. The Kaohsiung Journal of Medical Sciences published by John Wiley & Sons Australia, Ltd on behalf of Kaohsiung Medical University..
In order to accurately monitor graft immunology, we have developed a method for performing intestine and abdominal wall transplantation heterotopically in miniature swine. The procedure consisted of simultaneous segmental terminal ileum and full-thickness abdominal wall transplantation in Lanyu miniature swine, with the intestinal and the abdominal wall grafts being placed on the recipient's bilateral rear flank. Five transplantations were technically successful. One animal died on the first post-transplant day due to anesthesia-related issues, three abdominal wall and four intestinal grafts survived, while one abdominal wall graft failed due to vascular thrombosis. Acute cellular rejection (ACR) of the intestinal graft could occur preceding, simultaneously with or following ACR of the abdominal wall graft. Our experimental model demonstrates the technical feasibility of heterotopic intestine and abdominal wall transplantation in miniature swine without grafting in gastrointestinal continuity. This model could be suitable for further studies of graft immunology.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
The Kaohsiung journal of medical sciences - 39(2023), 11 vom: 13. Nov., Seite 1129-1134 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kuo, Yur-Ren [VerfasserIn] |
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| Links: |
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| Themen: |
Abdominal wall-vascularized composite allotransplantation |
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| Anmerkungen: |
Date Completed 09.11.2023 Date Revised 09.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/kjm2.12742 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360729843 |
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| 520 | |a © 2023 The Authors. The Kaohsiung Journal of Medical Sciences published by John Wiley & Sons Australia, Ltd on behalf of Kaohsiung Medical University. | ||
| 520 | |a In order to accurately monitor graft immunology, we have developed a method for performing intestine and abdominal wall transplantation heterotopically in miniature swine. The procedure consisted of simultaneous segmental terminal ileum and full-thickness abdominal wall transplantation in Lanyu miniature swine, with the intestinal and the abdominal wall grafts being placed on the recipient's bilateral rear flank. Five transplantations were technically successful. One animal died on the first post-transplant day due to anesthesia-related issues, three abdominal wall and four intestinal grafts survived, while one abdominal wall graft failed due to vascular thrombosis. Acute cellular rejection (ACR) of the intestinal graft could occur preceding, simultaneously with or following ACR of the abdominal wall graft. Our experimental model demonstrates the technical feasibility of heterotopic intestine and abdominal wall transplantation in miniature swine without grafting in gastrointestinal continuity. This model could be suitable for further studies of graft immunology | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Lanyu pig | |
| 650 | 4 | |a abdominal wall-vascularized composite allotransplantation | |
| 650 | 4 | |a intestinal transplantation | |
| 650 | 4 | |a miniature swine | |
| 700 | 1 | |a Chen, Yu-Han |e verfasserin |4 aut | |
| 700 | 1 | |a Yeh, Yung-Sung |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Chao-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ching-Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Ting-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Han-Ching |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Yu-Tang |e verfasserin |4 aut | |
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