Relationship between the distribution of intra-retinal hyper-reflective foci and the progression of intermediate age-related macular degeneration
© 2023. The Author(s)..
PURPOSE: To assess the relationship between the distribution of intra-retinal hyper-reflective foci (IHRF) on optical coherence tomography (OCT) and progression of intermediate age-related macular degeneration (iAMD) over 2 years.
METHODS: Cirrus OCT volumes of the macula of subjects enrolled in the Amish Eye Study with 2 years of follow-up were evaluated for the presence of iAMD and IHRF at baseline. The IHRF were counted in a series of 5 sequential en face slabs from outer to inner retina. The number of IHRF in each slab at baseline and the change in IHRF from baseline to year 2 were correlated with progression to late AMD at 2 years.
RESULTS: Among 120 eyes from 71 patients with iAMD, 52 eyes (43.3%) of 42 patients had evidence of both iAMD and IHRF at baseline. Twenty-three eyes (19.0%) showed progression to late AMD after 2 years. The total IHRF count increased from 243 at baseline to 604 at 2 years, with a significant increase in the IHRF number in each slab, except for the innermost slab 5 which had no IHRF at baseline or follow-up. The IHRF count increased from 121 to 340 in eyes that showed progression to late AMD. The presence of IHRF in the outermost retinal slabs 1 and 2 was independently associated with a significant risk of progression to late AMD. A greater increase in IHRF count over 2 years in these same slabs 1 and 2 was also associated with a higher risk of conversion to late AMD.
CONCLUSIONS: The risk of progression to late AMD appears to be significantly associated with the distribution and extent of IHRF in the outermost retinal layers. This observation may point to significant pathophysiologic differences of IHRF in inner versus outer layers of the retina.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:261 |
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| Enthalten in: |
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 261(2023), 12 vom: 08. Dez., Seite 3437-3447 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Verma, Aditya [VerfasserIn] |
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| Links: |
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| Themen: |
Intermediate age-related macular degeneration |
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| Anmerkungen: |
Date Completed 27.11.2023 Date Revised 27.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00417-023-06180-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Verma, Aditya |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Relationship between the distribution of intra-retinal hyper-reflective foci and the progression of intermediate age-related macular degeneration |
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| 500 | |a Date Revised 27.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a PURPOSE: To assess the relationship between the distribution of intra-retinal hyper-reflective foci (IHRF) on optical coherence tomography (OCT) and progression of intermediate age-related macular degeneration (iAMD) over 2 years | ||
| 520 | |a METHODS: Cirrus OCT volumes of the macula of subjects enrolled in the Amish Eye Study with 2 years of follow-up were evaluated for the presence of iAMD and IHRF at baseline. The IHRF were counted in a series of 5 sequential en face slabs from outer to inner retina. The number of IHRF in each slab at baseline and the change in IHRF from baseline to year 2 were correlated with progression to late AMD at 2 years | ||
| 520 | |a RESULTS: Among 120 eyes from 71 patients with iAMD, 52 eyes (43.3%) of 42 patients had evidence of both iAMD and IHRF at baseline. Twenty-three eyes (19.0%) showed progression to late AMD after 2 years. The total IHRF count increased from 243 at baseline to 604 at 2 years, with a significant increase in the IHRF number in each slab, except for the innermost slab 5 which had no IHRF at baseline or follow-up. The IHRF count increased from 121 to 340 in eyes that showed progression to late AMD. The presence of IHRF in the outermost retinal slabs 1 and 2 was independently associated with a significant risk of progression to late AMD. A greater increase in IHRF count over 2 years in these same slabs 1 and 2 was also associated with a higher risk of conversion to late AMD | ||
| 520 | |a CONCLUSIONS: The risk of progression to late AMD appears to be significantly associated with the distribution and extent of IHRF in the outermost retinal layers. This observation may point to significant pathophysiologic differences of IHRF in inner versus outer layers of the retina | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Intermediate age-related macular degeneration | |
| 650 | 4 | |a Intraretinal hyper-reflective foci | |
| 650 | 4 | |a Late age-related macular degeneration | |
| 650 | 4 | |a Optical coherence tomography | |
| 650 | 4 | |a Retinal pigment epithelium | |
| 700 | 1 | |a Corradetti, Giulia |e verfasserin |4 aut | |
| 700 | 1 | |a He, Ye |e verfasserin |4 aut | |
| 700 | 1 | |a Nittala, Muneeswar G |e verfasserin |4 aut | |
| 700 | 1 | |a Nassisi, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Velaga, Swetha B |e verfasserin |4 aut | |
| 700 | 1 | |a Haines, Jonathan L |e verfasserin |4 aut | |
| 700 | 1 | |a Pericak-Vance, Margaret A |e verfasserin |4 aut | |
| 700 | 1 | |a Stambolian, Dwight |e verfasserin |4 aut | |
| 700 | 1 | |a Sadda, SriniVas R |e verfasserin |4 aut | |
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