COVID-19 progression in hospitalized patients using follow-up in vivo CT and ex vivo microCT
2023 Journal of Thoracic Disease. All rights reserved..
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease-19 (COVID-19) which can lead to acute respiratory distress syndrome (ARDS) and evolve to pulmonary fibrosis. Computed tomography (CT) is used to study disease progression and describe radiological patterns in COVID-19 patients. This study aimed to assess disease progression regarding lung volume and density over time on follow-up in vivo chest CT and give a unique look at parenchymal and morphological airway changes in "end-stage" COVID-19 lungs using ex vivo microCT.
Methods: Volumes and densities of the lung/lobes of three COVID-19 patients were assessed using follow-up in vivo CT and ex vivo whole lung microCT scans. Airways were quantified by airway segmentations on whole lung microCT and small-partition microCT. As controls, three discarded healthy donor lungs were used. Histology was performed in differently affected regions in the COVID-19 lungs.
Results: In vivo, COVID-19 lung volumes decreased while density increased over time, mainly in lower lobes as previously shown. Ex vivo COVID-19 lung volumes decreased by 60% and all lobes were smaller compared to controls. Airways were more visible on ex vivo microCT in COVID-19, probably due to fibrosis and increased airway diameter. In addition, small-partition microCT showed more deformation of (small) airway morphology and fibrotic organization in severely affected regions with heterogeneous distributions within the same lung which was confirmed by histology.
Conclusions: COVID-19-ARDS and subsequent pulmonary fibrosis alters lung architecture and airway morphology which is described using in vivo CT, ex vivo microCT, and histology.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Journal of thoracic disease - 15(2023), 7 vom: 31. Juli, Seite 3646-3661 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Geudens, Vincent [VerfasserIn] |
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| Links: |
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| Themen: |
Airway morphology |
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| Anmerkungen: |
Date Revised 11.08.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.21037/jtd-22-1488 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360592414 |
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| 100 | 1 | |a Geudens, Vincent |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a COVID-19 progression in hospitalized patients using follow-up in vivo CT and ex vivo microCT |
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| 500 | |a Date Revised 11.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a 2023 Journal of Thoracic Disease. All rights reserved. | ||
| 520 | |a Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease-19 (COVID-19) which can lead to acute respiratory distress syndrome (ARDS) and evolve to pulmonary fibrosis. Computed tomography (CT) is used to study disease progression and describe radiological patterns in COVID-19 patients. This study aimed to assess disease progression regarding lung volume and density over time on follow-up in vivo chest CT and give a unique look at parenchymal and morphological airway changes in "end-stage" COVID-19 lungs using ex vivo microCT | ||
| 520 | |a Methods: Volumes and densities of the lung/lobes of three COVID-19 patients were assessed using follow-up in vivo CT and ex vivo whole lung microCT scans. Airways were quantified by airway segmentations on whole lung microCT and small-partition microCT. As controls, three discarded healthy donor lungs were used. Histology was performed in differently affected regions in the COVID-19 lungs | ||
| 520 | |a Results: In vivo, COVID-19 lung volumes decreased while density increased over time, mainly in lower lobes as previously shown. Ex vivo COVID-19 lung volumes decreased by 60% and all lobes were smaller compared to controls. Airways were more visible on ex vivo microCT in COVID-19, probably due to fibrosis and increased airway diameter. In addition, small-partition microCT showed more deformation of (small) airway morphology and fibrotic organization in severely affected regions with heterogeneous distributions within the same lung which was confirmed by histology | ||
| 520 | |a Conclusions: COVID-19-ARDS and subsequent pulmonary fibrosis alters lung architecture and airway morphology which is described using in vivo CT, ex vivo microCT, and histology | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Airway morphology | |
| 650 | 4 | |a coronavirus disease-19 (COVID-19) | |
| 650 | 4 | |a ex vivo micro-computed tomography (ex vivo microCT) | |
| 650 | 4 | |a in vivo chest CT | |
| 650 | 4 | |a lung density and volume | |
| 700 | 1 | |a Van Slambrouck, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Aerts, Gitte |e verfasserin |4 aut | |
| 700 | 1 | |a Willems, Lynn |e verfasserin |4 aut | |
| 700 | 1 | |a Goos, Tinne |e verfasserin |4 aut | |
| 700 | 1 | |a Kaes, Janne |e verfasserin |4 aut | |
| 700 | 1 | |a Zajacova, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Gyselinck, Iwein |e verfasserin |4 aut | |
| 700 | 1 | |a Aelbrecht, Celine |e verfasserin |4 aut | |
| 700 | 1 | |a Vermaut, Astrid |e verfasserin |4 aut | |
| 700 | 1 | |a Beeckmans, Hanne |e verfasserin |4 aut | |
| 700 | 1 | |a Vermant, Marie |e verfasserin |4 aut | |
| 700 | 1 | |a De Fays, Charlotte |e verfasserin |4 aut | |
| 700 | 1 | |a Sacreas, Annelore |e verfasserin |4 aut | |
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| 700 | 1 | |a Orlitova, Michaela |e verfasserin |4 aut | |
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| 700 | 1 | |a Josipovic, Ivan |e verfasserin |4 aut | |
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| 700 | 1 | |a Wuyts, Wim A |e verfasserin |4 aut | |
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| 700 | 1 | |a Ceulemans, Laurens J |e verfasserin |4 aut | |
| 700 | 1 | |a Vanaudenaerde, Bart M |e verfasserin |4 aut | |
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