Ultrasensitive levofloxacin electrochemical biosensor based on semiconducting covalent organic framework/poly-L-cysteine/triangular Ag nanoplates modified glassy carbon electrode
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature..
A novel electrochemical biosensor with excellent performance was fabricated for levofloxacin (LEV) detection, which adopted triangular Ag nanoplates (Tri-AgNP) confined in a poly-L-cysteine (poly-L-Cys) film and a semiconducting covalent organic framework (COF) as the electrochemical sensing material. The developed electrochemical sensor revealed excellent analytical properties because of its good electrical conductivity, fast electron transfer, and abundant bioactive site. Based on this, a linear relationship between the LEV concentration and the peak current response at 0.92 V was obtained under the optimal experimental conditions by differential pulse voltammetry (DPV), with a wide linear range of 0.05 to 600 μM and a low limit of detection (LOD) of 0.0061 μM. The prepared sensor also realized sensitive and accurate determination of LEV in human serum and urine samples by standard addition method, with satisfactory recoveries (97.1 to 104%) and a low relative standard deviation of less than 4.6%. These results indicated that the novel ternary system has a promising application in the development of electrochemical signal probe and electrochemical biosensing platform.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:190 |
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| Enthalten in: |
Mikrochimica acta - 190(2023), 9 vom: 09. Aug., Seite 346 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sun, Lei [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 10.08.2023 Date Revised 05.09.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00604-023-05866-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM360556108 |
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| 245 | 1 | 0 | |a Ultrasensitive levofloxacin electrochemical biosensor based on semiconducting covalent organic framework/poly-L-cysteine/triangular Ag nanoplates modified glassy carbon electrode |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature. | ||
| 520 | |a A novel electrochemical biosensor with excellent performance was fabricated for levofloxacin (LEV) detection, which adopted triangular Ag nanoplates (Tri-AgNP) confined in a poly-L-cysteine (poly-L-Cys) film and a semiconducting covalent organic framework (COF) as the electrochemical sensing material. The developed electrochemical sensor revealed excellent analytical properties because of its good electrical conductivity, fast electron transfer, and abundant bioactive site. Based on this, a linear relationship between the LEV concentration and the peak current response at 0.92 V was obtained under the optimal experimental conditions by differential pulse voltammetry (DPV), with a wide linear range of 0.05 to 600 μM and a low limit of detection (LOD) of 0.0061 μM. The prepared sensor also realized sensitive and accurate determination of LEV in human serum and urine samples by standard addition method, with satisfactory recoveries (97.1 to 104%) and a low relative standard deviation of less than 4.6%. These results indicated that the novel ternary system has a promising application in the development of electrochemical signal probe and electrochemical biosensing platform | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Covalent organic framework | |
| 650 | 4 | |a Differential pulse voltammetry | |
| 650 | 4 | |a Electrochemical biosensor | |
| 650 | 4 | |a Levofloxacin | |
| 650 | 4 | |a Poly-L-cysteine | |
| 650 | 4 | |a Triangular Ag nanoplates | |
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| 700 | 1 | |a Guo, Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Bingqing |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Zhilan |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Ning |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Wu |e verfasserin |4 aut | |
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