Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK)
© 2023 International Society of Nephrology. Published by Elsevier Inc..
Introduction: Continuous renal replacement therapy (CRRT) is used for the symptomatic management of acute kidney injury (AKI) and fluid overload (FO). Contemporary reports on pediatric CRRT are small and single center in design. Large international studies evaluating CRRT practice and outcomes are lacking. Herein, we describe the design of a multinational collaborative.
Methods: The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) is an international collaborative of pediatric specialists whose mission is to improve short- and long-term outcomes of children treated with CRRT. The aims of this multicenter retrospective study are to describe the epidemiology, liberation patterns, association of fluid balance and timing of CRRT initiation, and CRRT prescription with outcomes.
Results: We included children (n = 996, 0-25 years) admitted to an intensive care unit (ICU) and treated with CRRT for AKI or FO at 32 centers (in 7 countries) from 2018 to 2021. Demographics and clinical characteristics before CRRT initiation, during the first 7 days of both CRRT, and liberation were collected. Outcomes include the following: (i) major adverse kidney events at 90 days (mortality, dialysis dependence, and persistent kidney dysfunction), and (ii) functional outcomes (functional stats scale).
Conclusion: The retrospective WE-ROCK study represents the largest international registry of children receiving CRRT for AKI or FO. It will serve as a broad and invaluable resource for the field of pediatric critical care nephrology that will improve our understanding of practice heterogeneity and the association of CRRT with clinical and patient-centered outcomes. This will generate preliminary data for future interventional trials in this area.
Errataetall: |
ErratumIn: Kidney Int Rep. 2024 Jan 12;9(3):732. - PMID 38481509 |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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Enthalten in: |
Kidney international reports - 8(2023), 8 vom: 20. Aug., Seite 1542-1552 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Menon, Shina [VerfasserIn] |
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Links: |
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Themen: |
Acute kidney injury |
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Anmerkungen: |
Date Revised 30.03.2024 published: Electronic-eCollection ErratumIn: Kidney Int Rep. 2024 Jan 12;9(3):732. - PMID 38481509 Citation Status PubMed-not-MEDLINE |
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doi: |
10.1016/j.ekir.2023.05.026 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM360471978 |
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520 | |a © 2023 International Society of Nephrology. Published by Elsevier Inc. | ||
520 | |a Introduction: Continuous renal replacement therapy (CRRT) is used for the symptomatic management of acute kidney injury (AKI) and fluid overload (FO). Contemporary reports on pediatric CRRT are small and single center in design. Large international studies evaluating CRRT practice and outcomes are lacking. Herein, we describe the design of a multinational collaborative | ||
520 | |a Methods: The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) is an international collaborative of pediatric specialists whose mission is to improve short- and long-term outcomes of children treated with CRRT. The aims of this multicenter retrospective study are to describe the epidemiology, liberation patterns, association of fluid balance and timing of CRRT initiation, and CRRT prescription with outcomes | ||
520 | |a Results: We included children (n = 996, 0-25 years) admitted to an intensive care unit (ICU) and treated with CRRT for AKI or FO at 32 centers (in 7 countries) from 2018 to 2021. Demographics and clinical characteristics before CRRT initiation, during the first 7 days of both CRRT, and liberation were collected. Outcomes include the following: (i) major adverse kidney events at 90 days (mortality, dialysis dependence, and persistent kidney dysfunction), and (ii) functional outcomes (functional stats scale) | ||
520 | |a Conclusion: The retrospective WE-ROCK study represents the largest international registry of children receiving CRRT for AKI or FO. It will serve as a broad and invaluable resource for the field of pediatric critical care nephrology that will improve our understanding of practice heterogeneity and the association of CRRT with clinical and patient-centered outcomes. This will generate preliminary data for future interventional trials in this area | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a WE-ROCK | |
650 | 4 | |a acute kidney injury | |
650 | 4 | |a continuous renal replacement therapy | |
650 | 4 | |a database | |
650 | 4 | |a fluid overload | |
650 | 4 | |a pediatric | |
700 | 1 | |a Krallman, Kelli A |e verfasserin |4 aut | |
700 | 1 | |a Arikan, Ayse A |e verfasserin |4 aut | |
700 | 1 | |a Fuhrman, Dana Y |e verfasserin |4 aut | |
700 | 1 | |a Gorga, Stephen M |e verfasserin |4 aut | |
700 | 1 | |a Mottes, Theresa |e verfasserin |4 aut | |
700 | 1 | |a Ollberding, Nicholas |e verfasserin |4 aut | |
700 | 1 | |a Ricci, Zaccaria |e verfasserin |4 aut | |
700 | 1 | |a Stanski, Natalja L |e verfasserin |4 aut | |
700 | 1 | |a Selewski, David T |e verfasserin |4 aut | |
700 | 1 | |a Soranno, Danielle E |e verfasserin |4 aut | |
700 | 1 | |a Zappitelli, Michael |e verfasserin |4 aut | |
700 | 1 | |a Zang, Huaiyu |e verfasserin |4 aut | |
700 | 1 | |a Gist, Katja M |e verfasserin |4 aut | |
700 | 0 | |a WE-ROCK Investigators |e verfasserin |4 aut | |
700 | 1 | |a Ahern, Emily |e investigator |4 oth | |
700 | 1 | |a Akcan Arikan, Ayse |e investigator |4 oth | |
700 | 1 | |a Alhamoud, Issa |e investigator |4 oth | |
700 | 1 | |a Alobaidi, Rashid |e investigator |4 oth | |
700 | 1 | |a Anton-Martin, Pilar |e investigator |4 oth | |
700 | 1 | |a Balani, Shanthi S |e investigator |4 oth | |
700 | 1 | |a Barhight, Matthew |e investigator |4 oth | |
700 | 1 | |a Basalely, Abby |e investigator |4 oth | |
700 | 1 | |a Bigelow, Amee M |e investigator |4 oth | |
700 | 1 | |a Bottari, Gabriella |e investigator |4 oth | |
700 | 1 | |a Cappoli, Andrea |e investigator |4 oth | |
700 | 1 | |a Ciccia, Eileen A |e investigator |4 oth | |
700 | 1 | |a Collins, Michaela |e investigator |4 oth | |
700 | 1 | |a Colosimo, Denise |e investigator |4 oth | |
700 | 1 | |a Cortina, Gerard |e investigator |4 oth | |
700 | 1 | |a Damian, Mihaela A |e investigator |4 oth | |
700 | 1 | |a De la Mata Navazo, Sara |e investigator |4 oth | |
700 | 1 | |a DeAbreu, Gabrielle |e investigator |4 oth | |
700 | 1 | |a Deep, Akash |e investigator |4 oth | |
700 | 1 | |a Ding, Kathy L |e investigator |4 oth | |
700 | 1 | |a Dolan, Kristin J |e investigator |4 oth | |
700 | 1 | |a Fernandez Lafever, Sarah N |e investigator |4 oth | |
700 | 1 | |a Fuhrman, Dana Y |e investigator |4 oth | |
700 | 1 | |a Gelbart, Ben |e investigator |4 oth | |
700 | 1 | |a Gist, Katja M |e investigator |4 oth | |
700 | 1 | |a Gorga, Stephen M |e investigator |4 oth | |
700 | 1 | |a Guzzi, Francesco |e investigator |4 oth | |
700 | 1 | |a Guzzo, Isabella |e investigator |4 oth | |
700 | 1 | |a Haga, Taiki |e investigator |4 oth | |
700 | 1 | |a Harvey, Elizabeth |e investigator |4 oth | |
700 | 1 | |a Hasson, Denise C |e investigator |4 oth | |
700 | 1 | |a Hill-Horowitz, Taylor |e investigator |4 oth | |
700 | 1 | |a Inthavong, Haleigh |e investigator |4 oth | |
700 | 1 | |a Joseph, Catherine |e investigator |4 oth | |
700 | 1 | |a Kaddourah, Ahmad |e investigator |4 oth | |
700 | 1 | |a Kakajiwala, Aadil |e investigator |4 oth | |
700 | 1 | |a Kessel, Aaron D |e investigator |4 oth | |
700 | 1 | |a Korn, Sarah |e investigator |4 oth | |
700 | 1 | |a Krallman, Kelli A |e investigator |4 oth | |
700 | 1 | |a Kwiatkowski, David M |e investigator |4 oth | |
700 | 1 | |a Lee, Jasmine |e investigator |4 oth | |
700 | 1 | |a Lequier, Laurance |e investigator |4 oth | |
700 | 1 | |a Kia, Tina Madani |e investigator |4 oth | |
700 | 1 | |a Mah, Kenneth E |e investigator |4 oth | |
700 | 1 | |a Marinari, Eleonora |e investigator |4 oth | |
700 | 1 | |a Martin, Susan D |e investigator |4 oth | |
700 | 1 | |a Menon, Shina |e investigator |4 oth | |
700 | 1 | |a Mohamed, Tahagod H |e investigator |4 oth | |
700 | 1 | |a Morgan, Catherine |e investigator |4 oth | |
700 | 1 | |a Mottes, Theresa A |e investigator |4 oth | |
700 | 1 | |a Muff-Luett, Melissa A |e investigator |4 oth | |
700 | 1 | |a Namachivayam, Siva |e investigator |4 oth | |
700 | 1 | |a Neumayr, Tara M |e investigator |4 oth | |
700 | 1 | |a Md, Jennifer Nhan |e investigator |4 oth | |
700 | 1 | |a O'Rourke, Abigail |e investigator |4 oth | |
700 | 1 | |a Ollberding, Nicholas J |e investigator |4 oth | |
700 | 1 | |a Pinto, Matthew G |e investigator |4 oth | |
700 | 1 | |a Qutob, Dua |e investigator |4 oth | |
700 | 1 | |a Raggi, Valeria |e investigator |4 oth | |
700 | 1 | |a Reynaud, Stephanie |e investigator |4 oth | |
700 | 1 | |a Ricci, Zaccaria |e investigator |4 oth | |
700 | 1 | |a Rumlow, Zachary A |e investigator |4 oth | |
700 | 1 | |a Santiago Lozano, María J |e investigator |4 oth | |
700 | 1 | |a See, Emily |e investigator |4 oth | |
700 | 1 | |a Selewski, David T |e investigator |4 oth | |
700 | 1 | |a Serpe, Carmela |e investigator |4 oth | |
700 | 1 | |a Serratore, Alyssa |e investigator |4 oth | |
700 | 1 | |a Shah, Ananya |e investigator |4 oth | |
700 | 1 | |a Shih, Weiwen V |e investigator |4 oth | |
700 | 1 | |a Shin, H Stella |e investigator |4 oth | |
700 | 1 | |a Slagle, Cara L |e investigator |4 oth | |
700 | 1 | |a Solomon, Sonia |e investigator |4 oth | |
700 | 1 | |a Soranno, Danielle E |e investigator |4 oth | |
700 | 1 | |a Srivastava, Rachana |e investigator |4 oth | |
700 | 1 | |a Stanski, Natalja L |e investigator |4 oth | |
700 | 1 | |a Starr, Michelle C |e investigator |4 oth | |
700 | 1 | |a Stenson, Erin K |e investigator |4 oth | |
700 | 1 | |a Strong, Amy E |e investigator |4 oth | |
700 | 1 | |a Taylor, Susan A |e investigator |4 oth | |
700 | 1 | |a Thadani, Sameer V |e investigator |4 oth | |
700 | 1 | |a Uber, Amanda M |e investigator |4 oth | |
700 | 1 | |a Van Wyk, Brynna |e investigator |4 oth | |
700 | 1 | |a Webb, Tennille N |e investigator |4 oth | |
700 | 1 | |a Zang, Huaiyu |e investigator |4 oth | |
700 | 1 | |a Zangla, Emily E |e investigator |4 oth | |
700 | 1 | |a Zappitelli, Michael |e investigator |4 oth | |
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