P1 Glutamine isosteres in the design of inhibitors of 3C/3CL protease of human viruses of the Pisoniviricetes class
This journal is © The Royal Society of Chemistry..
Viral infections are one of the leading causes of acute morbidity in humans and much endeavour has been made by the synthetic community for the development of drugs to treat associated diseases. Peptide-based enzyme inhibitors, usually short sequences of three or four residues, are one of the classes of compounds currently under development for enhancement of their activity and pharmaceutical properties. This review reports the advances made in the design of inhibitors targeting the family of highly conserved viral proteases 3C/3CLpro, which play a key role in viral replication and present minimal homology with mammalian proteases. Particular focus is put on the reported development of P1 glutamine isosteres to generate potent inhibitors mimicking the natural substrate sequence at the site of recognition.'.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:4 |
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| Enthalten in: |
RSC chemical biology - 4(2023), 8 vom: 03. Aug., Seite 533-547 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Stubbing, Louise A [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Revised 08.08.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d3cb00075c |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM360471285 |
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| 520 | |a This journal is © The Royal Society of Chemistry. | ||
| 520 | |a Viral infections are one of the leading causes of acute morbidity in humans and much endeavour has been made by the synthetic community for the development of drugs to treat associated diseases. Peptide-based enzyme inhibitors, usually short sequences of three or four residues, are one of the classes of compounds currently under development for enhancement of their activity and pharmaceutical properties. This review reports the advances made in the design of inhibitors targeting the family of highly conserved viral proteases 3C/3CLpro, which play a key role in viral replication and present minimal homology with mammalian proteases. Particular focus is put on the reported development of P1 glutamine isosteres to generate potent inhibitors mimicking the natural substrate sequence at the site of recognition.' | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 700 | 1 | |a Hubert, Jonathan G |e verfasserin |4 aut | |
| 700 | 1 | |a Bell-Tyrer, Joseph |e verfasserin |4 aut | |
| 700 | 1 | |a Hermant, Yann O |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Sung Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a McSweeney, Alice M |e verfasserin |4 aut | |
| 700 | 1 | |a McKenzie-Goldsmith, Geena M |e verfasserin |4 aut | |
| 700 | 1 | |a Ward, Vernon K |e verfasserin |4 aut | |
| 700 | 1 | |a Furkert, Daniel P |e verfasserin |4 aut | |
| 700 | 1 | |a Brimble, Margaret A |e verfasserin |4 aut | |
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