Circulating short chain fatty acids and fatigue in patients with head and neck cancer : A longitudinal prospective study
Copyright © 2023 Elsevier Inc. All rights reserved..
Fatigue among patients with head and neck cancer (HNC) has been associated with higher inflammation. Short-chain fatty acids (SCFAs) have been shown to have anti-inflammatory and immunoregulatory effects. Therefore, this study aimed to examine the association between SCFAs and fatigue among patients with HNC undergoing treatment with radiotherapy with or without concurrent chemotherapy. Plasma SCFAs and the Multidimensional Fatigue Inventory-20 were collected prior to and one month after the completion of treatment in 59 HNC patients. The genome-wide gene expression profile was obtained from blood leukocytes prior to treatment. Lower butyrate concentrations were significantly associated with higher fatigue (p = 0.013) independent of time of assessment, controlling for covariates. A similar relationship was observed for iso/valerate (p = 0.025). Comparison of gene expression in individuals with the top and bottom 33% of butyrate or iso/valerate concentrations prior to radiotherapy revealed 1,088 and 881 significantly differentially expressed genes, respectively (raw p < 0.05). The top 10 Gene Ontology terms from the enrichment analyses revealed the involvement of pathways related to cytokines and lipid and fatty acid biosynthesis. These findings suggest that SCFAs may regulate inflammatory and immunometabolic responses and, thereby, reduce inflammatory-related symptoms, such as fatigue.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:113 |
|---|---|
| Enthalten in: |
Brain, behavior, and immunity - 113(2023) vom: 03. Okt., Seite 432-443 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Xiao, Canhua [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 04.09.2023 Date Revised 03.10.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.bbi.2023.07.025 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM360429386 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM360429386 | ||
| 003 | DE-627 | ||
| 005 | 20231226083008.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.bbi.2023.07.025 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1201.xml |
| 035 | |a (DE-627)NLM360429386 | ||
| 035 | |a (NLM)37543249 | ||
| 035 | |a (PII)S0889-1591(23)00218-0 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Xiao, Canhua |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Circulating short chain fatty acids and fatigue in patients with head and neck cancer |b A longitudinal prospective study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 04.09.2023 | ||
| 500 | |a Date Revised 03.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a Fatigue among patients with head and neck cancer (HNC) has been associated with higher inflammation. Short-chain fatty acids (SCFAs) have been shown to have anti-inflammatory and immunoregulatory effects. Therefore, this study aimed to examine the association between SCFAs and fatigue among patients with HNC undergoing treatment with radiotherapy with or without concurrent chemotherapy. Plasma SCFAs and the Multidimensional Fatigue Inventory-20 were collected prior to and one month after the completion of treatment in 59 HNC patients. The genome-wide gene expression profile was obtained from blood leukocytes prior to treatment. Lower butyrate concentrations were significantly associated with higher fatigue (p = 0.013) independent of time of assessment, controlling for covariates. A similar relationship was observed for iso/valerate (p = 0.025). Comparison of gene expression in individuals with the top and bottom 33% of butyrate or iso/valerate concentrations prior to radiotherapy revealed 1,088 and 881 significantly differentially expressed genes, respectively (raw p < 0.05). The top 10 Gene Ontology terms from the enrichment analyses revealed the involvement of pathways related to cytokines and lipid and fatty acid biosynthesis. These findings suggest that SCFAs may regulate inflammatory and immunometabolic responses and, thereby, reduce inflammatory-related symptoms, such as fatigue | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Fatigue | |
| 650 | 4 | |a Gene expression | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Radiotherapy, chemotherapy, head and neck cancer | |
| 650 | 4 | |a Short chain fatty acids | |
| 650 | 7 | |a Fatty Acids, Volatile |2 NLM | |
| 650 | 7 | |a Butyrates |2 NLM | |
| 650 | 7 | |a Valerates |2 NLM | |
| 700 | 1 | |a Fedirko, Veronika |e verfasserin |4 aut | |
| 700 | 1 | |a Claussen, Henry |e verfasserin |4 aut | |
| 700 | 1 | |a Richard Johnston, H |e verfasserin |4 aut | |
| 700 | 1 | |a Peng, Gang |e verfasserin |4 aut | |
| 700 | 1 | |a Paul, Sudeshna |e verfasserin |4 aut | |
| 700 | 1 | |a Maner-Smith, Kristal M |e verfasserin |4 aut | |
| 700 | 1 | |a Higgins, Kristin A |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Dong M |e verfasserin |4 aut | |
| 700 | 1 | |a Saba, Nabil F |e verfasserin |4 aut | |
| 700 | 1 | |a Wommack, Evanthia C |e verfasserin |4 aut | |
| 700 | 1 | |a Bruner, Deborah W |e verfasserin |4 aut | |
| 700 | 1 | |a Miller, Andrew H |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Brain, behavior, and immunity |d 1992 |g 113(2023) vom: 03. Okt., Seite 432-443 |w (DE-627)NLM012962538 |x 1090-2139 |7 nnns |
| 773 | 1 | 8 | |g volume:113 |g year:2023 |g day:03 |g month:10 |g pages:432-443 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.bbi.2023.07.025 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 113 |j 2023 |b 03 |c 10 |h 432-443 | ||