Melatonin : A look at protozoal and helminths
Copyright © 2023 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved..
Melatonin is a pleiotropic neurohormone found in different animal, plant, and microorganism species. It is a product resulting from tryptophan metabolism in the pineal gland and is widely known for its ability to synchronize the circadian rhythm to antitumor functions in different types of cancers. The molecular mechanisms responsible for its immunomodulatory, antioxidant and cytoprotective effects involve binding to high-affinity G protein-coupled receptors and interactions with intracellular targets that modulate signal transduction pathways. In vitro and in vivo studies have reported the therapeutic potential of melatonin in different infectious and parasitic diseases. In this review, the protective and pathophysiological roles of melatonin in fighting protozoan and helminth infections and the possible mechanisms involved against these stressors will be discussed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:219 |
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| Enthalten in: |
Biochimie - 219(2024) vom: 01. März, Seite 96-109 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ribeiro Franco, Pablo Igor [VerfasserIn] |
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| Links: |
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| Themen: |
Antioxidants |
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| Anmerkungen: |
Date Completed 15.03.2024 Date Revised 15.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.biochi.2023.07.021 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360412580 |
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| 520 | |a Copyright © 2023 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved. | ||
| 520 | |a Melatonin is a pleiotropic neurohormone found in different animal, plant, and microorganism species. It is a product resulting from tryptophan metabolism in the pineal gland and is widely known for its ability to synchronize the circadian rhythm to antitumor functions in different types of cancers. The molecular mechanisms responsible for its immunomodulatory, antioxidant and cytoprotective effects involve binding to high-affinity G protein-coupled receptors and interactions with intracellular targets that modulate signal transduction pathways. In vitro and in vivo studies have reported the therapeutic potential of melatonin in different infectious and parasitic diseases. In this review, the protective and pathophysiological roles of melatonin in fighting protozoan and helminth infections and the possible mechanisms involved against these stressors will be discussed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Helminths | |
| 650 | 4 | |a Host-parasite interactions | |
| 650 | 4 | |a Melatonin | |
| 650 | 4 | |a Parasites | |
| 650 | 4 | |a Protozoan infections | |
| 650 | 4 | |a Therapeutics | |
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| 650 | 7 | |a Antioxidants |2 NLM | |
| 700 | 1 | |a do Carmo Neto, José Rodrigues |e verfasserin |4 aut | |
| 700 | 1 | |a Guerra, Rhanoica Oliveira |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira da Silva, Priscilla Elias |e verfasserin |4 aut | |
| 700 | 1 | |a Braga, Yarlla Loyane Lira |e verfasserin |4 aut | |
| 700 | 1 | |a Nunes Celes, Mara Rúbia |e verfasserin |4 aut | |
| 700 | 1 | |a de Menezes, Liliana Borges |e verfasserin |4 aut | |
| 700 | 1 | |a Miguel, Marina Pacheco |e verfasserin |4 aut | |
| 700 | 1 | |a Machado, Juliana Reis |e verfasserin |4 aut | |
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