A systematic review and meta-analysis of miRNAs for the detection of cervical cancer
Aim: This study aimed to critically appraise the evidence of the diagnostic effectiveness of miRNAs for the detection of cervical cancer. Methods & materials: A systematic review and meta-analysis was performed, searching PubMed, EMBASE and Web of Science. An umbrella meta-analysis of meta-analyses of individual biomarkers was performed. A Grading of Recommendations, Assessment, Development and Evaluations (GRADE) assessment of evidence was also performed. Results: A total of 52 miRNAs were included. Umbrella meta-analysis revealed significant heterogeneity in terms of sensitivity, specificity, receiver operating characteristic (ROC), positive predictive value and/or negative predictive value. Umbrella effects were 0.76 (95% CI: 0.73-0.78), 0.78 (95% CI: 0.75-0.81), 0.77 (95% CI: 0.75-0.80), 0.75 (95% CI: 0.71-0.79) and 0.76 (95% CI: 0.74-0.79), respectively. Conclusion: Moderate quality evidence suggested miR199a-5p, miR21-5p and miR-141a had excellent diagnostic performance.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Epigenomics - 15(2023), 10 vom: 20. Mai, Seite 593-613 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hillyar, Christopher Rt [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 11.08.2023 Date Revised 15.08.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2217/epi-2023-0183 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360350593 |
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| 100 | 1 | |a Hillyar, Christopher Rt |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A systematic review and meta-analysis of miRNAs for the detection of cervical cancer |
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| 500 | |a Date Revised 15.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: This study aimed to critically appraise the evidence of the diagnostic effectiveness of miRNAs for the detection of cervical cancer. Methods & materials: A systematic review and meta-analysis was performed, searching PubMed, EMBASE and Web of Science. An umbrella meta-analysis of meta-analyses of individual biomarkers was performed. A Grading of Recommendations, Assessment, Development and Evaluations (GRADE) assessment of evidence was also performed. Results: A total of 52 miRNAs were included. Umbrella meta-analysis revealed significant heterogeneity in terms of sensitivity, specificity, receiver operating characteristic (ROC), positive predictive value and/or negative predictive value. Umbrella effects were 0.76 (95% CI: 0.73-0.78), 0.78 (95% CI: 0.75-0.81), 0.77 (95% CI: 0.75-0.80), 0.75 (95% CI: 0.71-0.79) and 0.76 (95% CI: 0.74-0.79), respectively. Conclusion: Moderate quality evidence suggested miR199a-5p, miR21-5p and miR-141a had excellent diagnostic performance | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a ROC | |
| 650 | 4 | |a biomarker | |
| 650 | 4 | |a cervical cancer | |
| 650 | 4 | |a cervical intraepithelial neoplasia | |
| 650 | 4 | |a meta-analysis | |
| 650 | 4 | |a miRNA sensitivity | |
| 650 | 4 | |a negative predictive value | |
| 650 | 4 | |a positive predictive value | |
| 650 | 4 | |a specificity | |
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| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Biomarkers, Tumor |2 NLM | |
| 700 | 1 | |a Kanabar, Shivani S |e verfasserin |4 aut | |
| 700 | 1 | |a Pufal, Kamil R |e verfasserin |4 aut | |
| 700 | 1 | |a Saw Hee, Joshua Li |e verfasserin |4 aut | |
| 700 | 1 | |a Lawson, Alexander W |e verfasserin |4 aut | |
| 700 | 1 | |a Mohamed, Yethrib |e verfasserin |4 aut | |
| 700 | 1 | |a Jasim, Duha |e verfasserin |4 aut | |
| 700 | 1 | |a Reed, Lara |e verfasserin |4 aut | |
| 700 | 1 | |a Rallis, Kathrine S |e verfasserin |4 aut | |
| 700 | 1 | |a Nibber, Anjan |e verfasserin |4 aut | |
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