Impact of fibrosis on liver-related event incidence in nonalcoholic fatty liver disease : A multicenter observational study
© 2023 Japan Society of Hepatology..
AIM: There are few reports on the prognosis of liver-related events in Japanese patients with nonalcoholic fatty liver disease (NAFLD). We undertook an observational study to compare the prognosis between fibrotic and nonfibrotic groups in Japanese NAFLD patients.
METHODS: Prognosis in 393 NAFLD patients who underwent liver biopsy between April 2013 and April 2015 at multiple centers were investigated. The time to onset of liver-related events, cardiovascular events, development of extrahepatic cancers, and death were compared between the pathologically fibrotic nonalcoholic steatohepatitis (NASH) group and nonalcoholic fatty liver (NAFL) + nonfibrotic NASH group. A similar analysis was carried out based on the fibrotic classification diagnosed using four noninvasive fibrosis prediction models.
RESULTS: The mean age and body mass index at the time of liver biopsy was 55.7 years old and 28.04 kg/m2 , respectively The cumulative incidence of liver-related events at 1080 days after liver biopsy was 5.79% in the pathologically fibrotic NASH group and 0% in the NAFL + nonfibrotic NASH group, with a significant difference (p = 0.0334). The cumulative incidence of liver-related events was significantly higher in the positive group for the prediction model than in the negative group in all four models (all p values were <0.0001). There was no significant difference between the pathologically fibrotic NASH group and NAFL + nonfibrotic NASH group in terms of cumulative incidence of cardiovascular events, development of extrahepatic cancers, and death.
CONCLUSIONS: The incidence of liver-related events was significantly higher in the fibrotic NASH group than that of the NAFL + nonfibrotic NASH group in Japanese NAFLD patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Hepatology research : the official journal of the Japan Society of Hepatology - 53(2023), 12 vom: 03. Dez., Seite 1169-1184 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chayama, Kazuaki [VerfasserIn] |
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| Links: |
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| Themen: |
Fibrosis |
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| Anmerkungen: |
Date Revised 02.12.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1111/hepr.13950 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM360344879 |
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| 100 | 1 | |a Chayama, Kazuaki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Impact of fibrosis on liver-related event incidence in nonalcoholic fatty liver disease |b A multicenter observational study |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 02.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 Japan Society of Hepatology. | ||
| 520 | |a AIM: There are few reports on the prognosis of liver-related events in Japanese patients with nonalcoholic fatty liver disease (NAFLD). We undertook an observational study to compare the prognosis between fibrotic and nonfibrotic groups in Japanese NAFLD patients | ||
| 520 | |a METHODS: Prognosis in 393 NAFLD patients who underwent liver biopsy between April 2013 and April 2015 at multiple centers were investigated. The time to onset of liver-related events, cardiovascular events, development of extrahepatic cancers, and death were compared between the pathologically fibrotic nonalcoholic steatohepatitis (NASH) group and nonalcoholic fatty liver (NAFL) + nonfibrotic NASH group. A similar analysis was carried out based on the fibrotic classification diagnosed using four noninvasive fibrosis prediction models | ||
| 520 | |a RESULTS: The mean age and body mass index at the time of liver biopsy was 55.7 years old and 28.04 kg/m2 , respectively The cumulative incidence of liver-related events at 1080 days after liver biopsy was 5.79% in the pathologically fibrotic NASH group and 0% in the NAFL + nonfibrotic NASH group, with a significant difference (p = 0.0334). The cumulative incidence of liver-related events was significantly higher in the positive group for the prediction model than in the negative group in all four models (all p values were <0.0001). There was no significant difference between the pathologically fibrotic NASH group and NAFL + nonfibrotic NASH group in terms of cumulative incidence of cardiovascular events, development of extrahepatic cancers, and death | ||
| 520 | |a CONCLUSIONS: The incidence of liver-related events was significantly higher in the fibrotic NASH group than that of the NAFL + nonfibrotic NASH group in Japanese NAFLD patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a fibrosis | |
| 650 | 4 | |a liver-related event | |
| 650 | 4 | |a nonalcoholic fatty liver disease | |
| 650 | 4 | |a prognosis | |
| 700 | 1 | |a Hiramatsu, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Shima, Toshihide |e verfasserin |4 aut | |
| 700 | 1 | |a Itoh, Yoshito |e verfasserin |4 aut | |
| 700 | 1 | |a Yamaguchi, Kanji |e verfasserin |4 aut | |
| 700 | 1 | |a Nakajima, Tomoaki |e verfasserin |4 aut | |
| 700 | 1 | |a Hoshikawa, Kyoko |e verfasserin |4 aut | |
| 700 | 1 | |a Kawamura, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Akuta, Norio |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Kiyoaki |e verfasserin |4 aut | |
| 700 | 1 | |a Kawanaka, Miwa |e verfasserin |4 aut | |
| 700 | 1 | |a Sakamoto, Michiie |e verfasserin |4 aut | |
| 700 | 1 | |a Harada, Kenichi |e verfasserin |4 aut | |
| 700 | 1 | |a Goto, Yoshihito |e verfasserin |4 aut | |
| 700 | 1 | |a Nakayama, Takeo |e verfasserin |4 aut | |
| 700 | 1 | |a Kumada, Hiromitsu |e verfasserin |4 aut | |
| 700 | 1 | |a Okanoue, Takeshi |e verfasserin |4 aut | |
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